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Study of Cannabidiol for Drug-Resistant Epilepsies

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT03014440
Expanded Access Status : No longer available
First Posted : January 9, 2017
Last Update Posted : April 4, 2017
University of Pittsburgh
Geisinger Clinic
Information provided by (Responsible Party):
Eric Marsh, MD, Children's Hospital of Philadelphia

Brief Summary:
The purpose of this study is to determine if cannabidiol is safe and effective at different doses as an additional treatment for pediatric drug-resistant epilepsy. Pure cannabidiol has potentially therapeutic properties, such as anti-convulsant effects, that may reduce seizure frequency. There are only a few open label studies that have demonstrated the safety and tolerance of cannabiodiol in both adult and pediatric epileptic populations--these studies were performed either retrospectively or with varying cannabidiol preparations. There are no well-documented studies and completely analyzed data for pediatric epileptic patients.

Condition or disease Intervention/treatment
Drug Resistant Epilepsy Drug: Cannabidiol

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Study Type : Expanded Access
Official Title: A Phase 1/2, Safety, Tolerability, and Dose-Finding Study of Cannabidiol for Drug-Resistant Epilepsies

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Epilepsy
Drug Information available for: Cannabidiol

Intervention Details:
  • Drug: Cannabidiol
    Other Names:
    • CBD
    • Epidiolex

Information from the National Library of Medicine

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Ages Eligible for Study:   1 Year to 20 Years   (Child, Adult)
Sexes Eligible for Study:   All

Inclusion Criteria:

  1. Ages between 1 year old and 20 years old, male or female at the first visit, Week -4 (at time informed consent form is signed)
  2. Documentation of a diagnosis of drug-resistant epilepsy as proven by and documented with medical records and/or the following clinical features (must have all 3 of the following):

    1. Failure to control seizures despite appropriate trial of 3 or more AEDs at therapeutic doses
    2. An intractable childhood epilepsy including, Dravet Syndrome or Lennox-Gastaut Syndrome
    3. Must report at least 3 countable (non-countable seizures includes absence and myoclonic) seizures per month
  3. Between 1-3 baseline AEDs . Vagus nerve stimulator (VNS), ketogenic diet, and modified Atkins diet do not count towards this limit.
  4. VNS must be on stable settings for a minimum of 3 months.
  5. If on the ketogenic diet, must be on stable ratio for a minimum of 3 months.

Exclusion Criteria:

  1. Epilepsies associated with neurodegenerative diseases, including neuronal ceroidolipofuscinosis, progressive myoclonus epilepsies, Rasmussen encephalitis, and tumors
  2. Epilepsies associated with an inborn error of metabolism, including mitochondrial disorders
  3. Felbatol initiated within the past 12 months
  4. Use of any Cannabis-related product (including hemp oil) in the past 12 months as assessed by parental questioning.
  5. Laboratory values on comprehensive metabolic panel (CMP) and complete blood count (CBC) testing that are Class 3 or higher according to the CTCAE v4.0.
  6. Positive pregnancy test.

No Contacts or Locations Provided
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Responsible Party: Eric Marsh, MD, Assistant Professor of Pediatrics and Neurology, Children's Hospital of Philadelphia Identifier: NCT03014440    
Other Study ID Numbers: 13-010562
First Posted: January 9, 2017    Key Record Dates
Last Update Posted: April 4, 2017
Last Verified: March 2017
Additional relevant MeSH terms:
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Drug Resistant Epilepsy
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases