Glucobrassicin-Brussel Sprout Effect on D10 Phe Metabolism
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|ClinicalTrials.gov Identifier: NCT02999399|
Recruitment Status : Active, not recruiting
First Posted : December 21, 2016
Last Update Posted : November 6, 2017
|Condition or disease||Intervention/treatment||Phase|
|Smoking||Other: Brussel Sprouts Drug: Deuterated Phenanthrene||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||48 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Assessing the Effect of Glucobrassicin-Rich Brussels Sprouts on the Metabolism of Deuterated Phenanthrene: Developing Food-Based Chemoprevention of Tobacco-Related Lung Cancer|
|Study Start Date :||December 2016|
|Estimated Primary Completion Date :||June 2018|
|Estimated Study Completion Date :||June 2019|
Experimental: [D10]phe and Brussels sprouts
All subjects are given 1 microgram [D10]phe before and after consuming Brussels sprouts once daily for 7 consecutive days.
Other: Brussel Sprouts
Subjects are given ~150 g of Brussels sprouts once daily for 7 consecutive days.
Drug: Deuterated Phenanthrene
Subjects are given 1 microgram of deuterated phenanthrene [D10]phe at baseline and after 7 days of Brussels sprout consumption. Urine is collected for 6 hours after each dose.
- Change in [D10]phenanthrene tetraol [ Time Frame: 7 days ]Compare level of urinary [D10]phenanthrene tetraol before and after 7 days of Brussels sprout consumption.
- Change in [D10]phenanthrols [ Time Frame: 7 days ]Compare level of urinary [D10]phenanthrene phenanthrols before and after 7 days of Brussels sprout consumption.
- Change in [D10]phenanthrene tetraol:[D10]phenanthrol ratio [ Time Frame: 7 days ]Compare level of urinary [D10]phenanthrene phenanthrols before and after 7 days of Brussels sprout consumption.
- Urinary 3,3'-diindolylmethane (DIM) [ Time Frame: Day 3 and Day 6 ]Urinary DIM will be quantified after Brussels sprout consumption on day 3 and day 6 of the feeding intervention for urinary DIM quantification
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02999399
|United States, Minnesota|
|University of Minnesota|
|Minneapolis, Minnesota, United States, 55455|
|Principal Investigator:||Naomi Fujioka, MD||University of Minnesota - Clinical and Translational Science Institute|