Glucobrassicin-Brussel Sprout Effect on D10 Phe Metabolism
|ClinicalTrials.gov Identifier: NCT02999399|
Recruitment Status : Active, not recruiting
First Posted : December 21, 2016
Last Update Posted : November 6, 2017
|Condition or disease||Intervention/treatment||Phase|
|Smoking||Other: Brussel Sprouts Drug: Deuterated Phenanthrene||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||48 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Assessing the Effect of Glucobrassicin-Rich Brussels Sprouts on the Metabolism of Deuterated Phenanthrene: Developing Food-Based Chemoprevention of Tobacco-Related Lung Cancer|
|Study Start Date :||December 2016|
|Estimated Primary Completion Date :||June 2018|
|Estimated Study Completion Date :||June 2019|
Experimental: [D10]phe and Brussels sprouts
All subjects are given 1 microgram [D10]phe before and after consuming Brussels sprouts once daily for 7 consecutive days.
Other: Brussel Sprouts
Subjects are given ~150 g of Brussels sprouts once daily for 7 consecutive days.Drug: Deuterated Phenanthrene
Subjects are given 1 microgram of deuterated phenanthrene [D10]phe at baseline and after 7 days of Brussels sprout consumption. Urine is collected for 6 hours after each dose.
- Change in [D10]phenanthrene tetraol [ Time Frame: 7 days ]Compare level of urinary [D10]phenanthrene tetraol before and after 7 days of Brussels sprout consumption.
- Change in [D10]phenanthrols [ Time Frame: 7 days ]Compare level of urinary [D10]phenanthrene phenanthrols before and after 7 days of Brussels sprout consumption.
- Change in [D10]phenanthrene tetraol:[D10]phenanthrol ratio [ Time Frame: 7 days ]Compare level of urinary [D10]phenanthrene phenanthrols before and after 7 days of Brussels sprout consumption.
- Urinary 3,3'-diindolylmethane (DIM) [ Time Frame: Day 3 and Day 6 ]Urinary DIM will be quantified after Brussels sprout consumption on day 3 and day 6 of the feeding intervention for urinary DIM quantification
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02999399
|United States, Minnesota|
|University of Minnesota|
|Minneapolis, Minnesota, United States, 55455|
|Principal Investigator:||Naomi Fujioka, MD||University of Minnesota - Clinical and Translational Science Institute|