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The Copenhagen City Heart Study (CCHS)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT02993172
First Posted: December 15, 2016
Last Update Posted: December 15, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Eva Prescott, Bispebjerg Hospital
  Purpose
The Copenhagen City Heart Study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population. The initial sample has been re-invited up to four times and supplemented by younger individuals. The study includes questionnaires, clinical assessment and biomarkers. The population have been followed in a number of outcome registries and more than 900 scientific papers have been published.

Condition
Coronary Heart Disease Stroke Heart Failure Cancer Myocardial Infarction Chronic Obstructive Pulmonary Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Copenhagen City Heart Study 'Østerbroundersøgelsen'

Further study details as provided by Eva Prescott, Bispebjerg Hospital:

Primary Outcome Measures:
  • Registry based disease outcomes, mainly cardiovascular, pulmonary and cancer outcomes [ Time Frame: Latest registry update december 31 2014 ]

Enrollment: 23891
Study Start Date: January 1976
Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Detailed Description:

The Copenhagen City Heart Study, also known as "Østerbroundersøgelsen", is a large prospective cardio-vascular population study of 20,000 women and men that was launched in 1975 by Dr Peter Schnohr and Dr Gorm Jensen together with statistician Jørgen Nyboe and Prof. A. Tybjærg Hansen.

The original purpose of the study was to focus on prevention of coronary heart disease and stroke. During the years many other aspects have been added to the study: pulmonary diseases, heart failure, arrhythmia, alcohol, arthrosis, eye diseases, allergy, epilepsia, dementia, stress, vital exhaustion, social network, sleep-apnoe, ageing and genetics. In the fourth and fifth wave of the examination echocardiography was included.

The Copenhagen City Heart Study has invited a random sample of the census population in an area of central Copenhagen in five waves. The primary population was a random sample of 19,329 men and women 20-93 years old, drawn from a population of approximately 90,000 inhabitants aged 20 years or older living in a central part of Copenhagen (Østerbro). Using the unique personal identification number (Central-Personal-Register-code), consisting of date of birth and a registration number, the sample was age-stratified within 5-year age groups, with the main emphasis on the age groups from 35 to 70 years. The total number of participants invited to the first four examinations was: 19,329+500+3,000+1,062 = 23,891 men and women. Of the original 14,223 examined at the first examination 3,092 (21.7%) have been examined in all four examinations.

Follow-up of mortality and morbidity using the unique personal identification number is performed by linkage to a number of nation-wide disease registries. Follow-up completion rate is almost 100 percent (less than 0.1% have been lost to follow-up mainly through emigration), which is very uncommon for large population studies.

Overview of the patients examined in the Copenhagen City Heart Study:

  1. st exam: 1976-78, 19,329 invited, 14,223 (73.6%) attended
  2. nd exam: 1981-83, 18,059 invited, 12,698 (71.2%) attended
  3. rd exam: 1991-94, 16,563 invited, 10.135 (61.2%) attended
  4. th exam: 2001-03,12,600 invited, 6,238 (49.5%) attended
  5. th exam: 2011-2014, approx 10,000 invited, approx 5000 (50%) attended

The Copenhagen City Heart Study is governed by a Steering Committee. The data from the Copenhagen City Heart Study is made available to researchers upon application to and approval by the Steering Committee. The following constitute the Steering Committee:

Gorm Jensen and Peter Schnohr (initiators), Peter Lange, Eva Prescott, Børge Nordestgaard, Morten Grønbæk, Anne Tybjærg Hansen, Stig Bojesen, Finn Gyntelberg, Jan Skov Jensen and Merete Appleyard

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Age.stratified random sample of the census population
Criteria

Inclusion Criteria:

  • Background population living in a defined area of Copenhagen

Exclusion Criteria:

  Contacts and Locations
No Contacts or Locations Provided
  More Information

Responsible Party: Eva Prescott, Professor, Bispebjerg Hospital
ClinicalTrials.gov Identifier: NCT02993172     History of Changes
Other Study ID Numbers: CCHS
First Submitted: December 9, 2016
First Posted: December 15, 2016
Last Update Posted: December 15, 2016
Last Verified: December 2016

Additional relevant MeSH terms:
Heart Failure
Lung Diseases
Infarction
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Heart Diseases
Myocardial Infarction
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Cardiovascular Diseases
Respiratory Tract Diseases
Ischemia
Pathologic Processes
Necrosis
Vascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases