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Effect of Exercise on Premature Ejaculation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02984592
Recruitment Status : Completed
First Posted : December 7, 2016
Last Update Posted : February 3, 2017
Sponsor:
Information provided by (Responsible Party):
Muhammet Fatih Kilinc, Ankara Training and Research Hospital

Study Description
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Brief Summary:
Premature ejaculation (PE) is one of the prevalent disorders in men; its leading sequel such as lack of self-confidence, anxiety, depression and unsatisfactory intercourse in men and their partners. The current study was aimed to evaluate the relationship between ejaculation and physical activity.

Condition or disease Intervention/treatment
Premature Ejaculation Behavioral: physical exercise

Detailed Description:

Premature ejaculation (PE) is the most frequent sexual dysfunction in males, and its prevalence has been reported as 21-33%. Currently, there are no universal criteria for the diagnosis, or treatment strategies or approaches for PE. Lack of observational studies directed to PE makes comprehension of this sexual dysfunction difficult. The common point for definition of PE is a short duration between penetration and ejaculation, little or no control on voluntary control of ejaculation, and annoying character and negative effect of this condition on the individual. There are various treatment methods since ejaculation physiology and neuroanatomy is not yet clearly demonstrated. According to neurobiological hypothesis of Waldinger, a dysfunction in the serotonin pathway of the central system such as serotonin-2C hyposensitivity and/or serotonin-1A receptor hypersensitivity is a possible cause of lifelong PE. These experimental animal models showed that serotonergic activity at hypothalamic level inhibited ejaculation reflex. Based on this physiological effect, selective serotonin reuptake inhibitors (SSRI), and serotonin agonists increase intravaginal ejaculation latency time (IELT). A number of studies showed that exercise increased the functional effect of serotonin in the human brain.

The effects of physical activity level on human health have attracted interest worldwide. Lack of physical activity forms the basis of various health problems, however regular physical act contributes prevention and treatment of a number of disorders.

In current study, investigators will compare the ejaculation control, IELT, and prevalence of PE between sportsmen that have regular physical activity, and the individuals with a sedentary lifestyle.

Study Design
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Study Type : Observational [Patient Registry]
Actual Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Target Follow-Up Duration: 1 Month
Official Title: Regular Physical Activity Improves Ejaculation Time and Patient-reported Outcomes
Study Start Date : November 2016
Actual Primary Completion Date : January 31, 2017
Actual Study Completion Date : January 31, 2017
Groups and Cohorts
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Group/Cohort Intervention/treatment
Group 1
The participants in group 1 will state that they participate regular exercise programs in the previous 6 months
 Behavioral: physical exercise
regular exercise programs in the previous 6 months.
Group 2
The participants in group 2 will state that they do not perform any regular exercise in previous 6 months.


Outcome Measures
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Primary Outcome Measures :
  1. intravaginal ejaculatory latency time [ Time Frame: 1 month ]
    IELT value (second) according to the duration determined by the sexual partner with stopwatch method


Secondary Outcome Measures :
  1. Premature ejaculation diagnostic tool score [ Time Frame: 1 month ]
    Premature Ejaculation Diagnostic Tool (PEDT) includes five items; control, frequency, minimal stimulation, distress, and interpersonal difficulty. In this classification tool, score 8 indicates no premature ejaculation, scores 9 and 10 indicate possible premature ejaculation, and scores equal or higher than 11 indicates premature ejaculation.


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The participants are 18-45 year-old, and have regular sexual activity for at least 6 months. A comparison was made by metabolic equivalents (MET), premature ejaculation diagnostic tool (PEDT) and intravaginal ejaculatory latency time (IELT).
Criteria

Inclusion Criteria:

  • 18-45-year-old
  • sexually active
  • heterosexual,without erectile dysfunction
  • sexual partner for at least six months, and sexual intercourse at least twice a week

Exclusion Criteria:

  • chronic systemic disorders (such as diabetes or hypertension)
  • use of narcotic/hypnotic drugs or stimulants
  • anabolic steroids
  • selective serotonin receptors inhibitors
  • previous diagnosis and treatment for PE
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02984592


Locations
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Turkey
Ankara Training and Research Hospital
Ankara, Turkey, 06340
Sponsors and Collaborators
Ankara Training and Research Hospital
More Information
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Additional Information:

Publications of Results:

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Responsible Party: Muhammet Fatih Kilinc, M.D., Ankara Training and Research Hospital
ClinicalTrials.gov Identifier: NCT02984592    
Other Study ID Numbers: 5006
First Posted: December 7, 2016    Key Record Dates
Last Update Posted: February 3, 2017
Last Verified: February 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Keywords provided by Muhammet Fatih Kilinc, Ankara Training and Research Hospital:
premature ejaculation
intravaginal ejaculatory latency time
premature ejaculation diagnostic tools
Additional relevant MeSH terms:
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Premature Birth
Premature Ejaculation
Obstetric Labor, Premature
Obstetric Labor Complications
Pregnancy Complications
Female Urogenital Diseases and Pregnancy Complications
Urogenital Diseases
 Genital Diseases, Male
Genital Diseases
Sexual Dysfunction, Physiological
Male Urogenital Diseases
Sexual Dysfunctions, Psychological
Mental Disorders