Effect of Exercise on Premature Ejaculation
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|ClinicalTrials.gov Identifier: NCT02984592|
Recruitment Status : Completed
First Posted : December 7, 2016
Last Update Posted : February 3, 2017
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|Condition or disease||Intervention/treatment|
|Premature Ejaculation||Behavioral: physical exercise|
Premature ejaculation (PE) is the most frequent sexual dysfunction in males, and its prevalence has been reported as 21-33%. Currently, there are no universal criteria for the diagnosis, or treatment strategies or approaches for PE. Lack of observational studies directed to PE makes comprehension of this sexual dysfunction difficult. The common point for definition of PE is a short duration between penetration and ejaculation, little or no control on voluntary control of ejaculation, and annoying character and negative effect of this condition on the individual. There are various treatment methods since ejaculation physiology and neuroanatomy is not yet clearly demonstrated. According to neurobiological hypothesis of Waldinger, a dysfunction in the serotonin pathway of the central system such as serotonin-2C hyposensitivity and/or serotonin-1A receptor hypersensitivity is a possible cause of lifelong PE. These experimental animal models showed that serotonergic activity at hypothalamic level inhibited ejaculation reflex. Based on this physiological effect, selective serotonin reuptake inhibitors (SSRI), and serotonin agonists increase intravaginal ejaculation latency time (IELT). A number of studies showed that exercise increased the functional effect of serotonin in the human brain.
The effects of physical activity level on human health have attracted interest worldwide. Lack of physical activity forms the basis of various health problems, however regular physical act contributes prevention and treatment of a number of disorders.
In current study, investigators will compare the ejaculation control, IELT, and prevalence of PE between sportsmen that have regular physical activity, and the individuals with a sedentary lifestyle.
|Study Type :||Observational [Patient Registry]|
|Actual Enrollment :||50 participants|
|Target Follow-Up Duration:||1 Month|
|Official Title:||Regular Physical Activity Improves Ejaculation Time and Patient-reported Outcomes|
|Study Start Date :||November 2016|
|Actual Primary Completion Date :||January 31, 2017|
|Actual Study Completion Date :||January 31, 2017|
The participants in group 1 will state that they participate regular exercise programs in the previous 6 months
Behavioral: physical exercise
regular exercise programs in the previous 6 months.
The participants in group 2 will state that they do not perform any regular exercise in previous 6 months.
- intravaginal ejaculatory latency time [ Time Frame: 1 month ]IELT value (second) according to the duration determined by the sexual partner with stopwatch method
- Premature ejaculation diagnostic tool score [ Time Frame: 1 month ]Premature Ejaculation Diagnostic Tool (PEDT) includes five items; control, frequency, minimal stimulation, distress, and interpersonal difficulty. In this classification tool, score 8 indicates no premature ejaculation, scores 9 and 10 indicate possible premature ejaculation, and scores equal or higher than 11 indicates premature ejaculation.
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|Ages Eligible for Study:||18 Years to 45 Years (Adult)|
|Sexes Eligible for Study:||Male|
|Accepts Healthy Volunteers:||Yes|
|Sampling Method:||Probability Sample|
- sexually active
- heterosexual,without erectile dysfunction
- sexual partner for at least six months, and sexual intercourse at least twice a week
- chronic systemic disorders (such as diabetes or hypertension)
- use of narcotic/hypnotic drugs or stimulants
- anabolic steroids
- selective serotonin receptors inhibitors
- previous diagnosis and treatment for PE
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02984592
|Ankara Training and Research Hospital|
|Ankara, Turkey, 06340|
Publications of Results:
|Responsible Party:||Muhammet Fatih Kilinc, M.D., Ankara Training and Research Hospital|
|Other Study ID Numbers:||
|First Posted:||December 7, 2016 Key Record Dates|
|Last Update Posted:||February 3, 2017|
|Last Verified:||February 2017|
|Individual Participant Data (IPD) Sharing Statement:|
|Plan to Share IPD:||Yes|
intravaginal ejaculatory latency time
premature ejaculation diagnostic tools
Obstetric Labor, Premature
Obstetric Labor Complications
Female Urogenital Diseases and Pregnancy Complications
Genital Diseases, Male
Sexual Dysfunction, Physiological
Male Urogenital Diseases
Sexual Dysfunctions, Psychological