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Brown Adipose Tissue in Type 1 Diabetes

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ClinicalTrials.gov Identifier: NCT02984514
Recruitment Status : Active, not recruiting
First Posted : December 7, 2016
Last Update Posted : October 27, 2017
Sponsor:
Information provided by (Responsible Party):
Per-Ola Carlsson, Uppsala University Hospital

Brief Summary:

Brown adipose tissue has the capacity to consume large amounts of energy and has insulin-independent glucose uptake. The investigators have recently observed an inverse correlation between irisin levels and insulin needs of type 1 diabetes patients. Transplantation of brown adipose tissue to insulin-deficient rats normalized their blood glucose levels.

In this study 12 patients with long-standing type 1 diabetes (>10 years) and with variable exogenous insulin needs will be investigated for amount of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose.


Condition or disease Intervention/treatment Phase
Type1diabetes Radiation: Positron emission tomography with tracer 18F-deoxy glucose Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 11 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Studies of Activity of Brown Adipose Tissue With Positron Emission Tomography Using the Tracer 18F-deoxy Glucose in Patients With Type 1 Diabetes
Study Start Date : October 2015
Estimated Primary Completion Date : September 2018
Estimated Study Completion Date : September 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Diabetes Type 1
Drug Information available for: Dextrose
U.S. FDA Resources

Arm Intervention/treatment
Experimental: Type 1 diabetes
Positron emission tomography with tracer 18F-deoxy glucose
Radiation: Positron emission tomography with tracer 18F-deoxy glucose
Assessment of activity of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose



Primary Outcome Measures :
  1. Activity of brown adipose tissue in correlation to exogenous insulin needs using the tracer 18F-deoxy glucose in positron emission tomography measurements [ Time Frame: Assessment performed after more than 10 years of diagnosed type 1 diabetes ]

Secondary Outcome Measures :
  1. Glucose uptake in muscle in correlation to exogenous insulin needs; assessment using the tracer 18F deoxy glucose in positron emission tomography measurements. [ Time Frame: Assessment performed after more than 10 years of diagnosed type 1 diabetes ]


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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Adult patients (18 years of age or more)
  2. Type 1 diabetes diagnose for more than 10 years

Exclusion Criteria:

  1. Ongoing pregnancy
  2. Ongoing breast-feeding
  3. BMI<19
  4. BMI >30
  5. P-creatinine <110 µmol/l

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02984514


Locations
Sweden
Uppsala University Hospital
Uppsala, Sweden, 751 23
Sponsors and Collaborators
Per-Ola Carlsson

Responsible Party: Per-Ola Carlsson, Professor, Senior consultant, Uppsala University Hospital
ClinicalTrials.gov Identifier: NCT02984514     History of Changes
Other Study ID Numbers: Dnr 2015/191
First Posted: December 7, 2016    Key Record Dates
Last Update Posted: October 27, 2017
Last Verified: October 2017

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 1
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Autoimmune Diseases
Immune System Diseases
Deoxyglucose
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Antiviral Agents
Anti-Infective Agents