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Weaning Outcome From Invasive Mechanical Ventilation

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ClinicalTrials.gov Identifier: NCT02981589
Recruitment Status : Recruiting
First Posted : December 5, 2016
Last Update Posted : December 6, 2016
Sponsor:
Information provided by (Responsible Party):
Zujin Luo, Beijing Chao Yang Hospital

Brief Summary:
The main purpose of the present study was to explore the weaning failure rate from invasive mechanical ventilation and to identify risk factors of weaning failure.

Condition or disease Intervention/treatment
Patients Requiring Endotracheal Intubation and Invasive Mechanical Ventilation Device: Invasive mechanical ventilation

Study Type : Observational
Estimated Enrollment : 300 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Weaning Outcome From Invasive Mechanical Ventilation: a Prospective, Observational Cohort Study
Study Start Date : July 2013
Estimated Primary Completion Date : December 2016

Intervention Details:
    Device: Invasive mechanical ventilation
    Invasive ventilation was performed to all eligible patients. When patients met predefined criteria, spontaneous breathing trial was performed. Given spontaneous breathing trial passed, patients were extubated; on the contrary, patients would continue to receive invasive ventilation. If patients had respiratory failure after extubation, reintubation and invasive ventilation were necessary.


Primary Outcome Measures :
  1. Weaning failure rate [ Time Frame: 3.5 years ]
  2. Spontaneous breathing trial failure rate [ Time Frame: 3.5 years ]
  3. Extubation failure rate [ Time Frame: 3.5 years ]

Secondary Outcome Measures :
  1. ICU mortality [ Time Frame: 3.5 years ]
  2. Hospital mortality [ Time Frame: 3.5 years ]
  3. ICU length of stay [ Time Frame: 3.5 years ]
  4. Hospital length of stay [ Time Frame: 3.5 years ]


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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients requiring endotracheal intubation and invasive mechanical ventilation
Criteria

Inclusion Criteria:

  • Requiring endotracheal intubation and invasive mechanical ventilation

Exclusion Criteria:

  • Duration of invasive mechanical ventilation < 48 hours;
  • Presence of tracheostomy;
  • Presence of upper airway obstruction.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02981589


Contacts
Contact: Zujin Luo, MD xmjg2002@163.com

Locations
China
Respiratory intensive care unit, Beijing Chao Yang Hospital Jingxi Campus Recruiting
Beiling, China
Contact: Zujin Luo, MD       xmjg2002@163.com   
Sponsors and Collaborators
Beijing Chao Yang Hospital
Investigators
Principal Investigator: Zujin Luo, MD Beijing Chao Yang Hospital

Responsible Party: Zujin Luo, MD, Beijing Chao Yang Hospital
ClinicalTrials.gov Identifier: NCT02981589     History of Changes
Other Study ID Numbers: BeijingCYH-ICU-003
First Posted: December 5, 2016    Key Record Dates
Last Update Posted: December 6, 2016
Last Verified: December 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No