Sit Less, Interact, Move More (SLIMM) Intervention for Sedentary Behavior in Chronic Kidney Disease (CKD) (SLIMM)
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ClinicalTrials.gov Identifier: NCT02970123 |
Recruitment Status :
Completed
First Posted : November 21, 2016
Last Update Posted : September 17, 2019
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Sedentary behavior is engaging in activities in the seated or lying position that barely raise the energy expenditure level and has emerged as an important risk factor for obesity, diabetes, cardiovascular disease and mortality.
The primary hypothesis is that the Sit Less, Interact, Move More (SLIMM) intervention in Chronic Kidney Disease (CKD) will be effective in decreasing sedentary duration by increasing casual walking duration and thereby, increase physical activity energy expenditure.
Condition or disease | Intervention/treatment | Phase |
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Chronic Kidney Disease | Behavioral: Sit Less, Interact, Move More (SLIMM) | Not Applicable |

Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 106 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Supportive Care |
Official Title: | Sit Less, Interact, Move More (SLIMM) Intervention for Sedentary Behavior in Chronic Kidney Disease (CKD) |
Actual Study Start Date : | December 2016 |
Actual Primary Completion Date : | September 12, 2019 |
Actual Study Completion Date : | September 12, 2019 |

Arm | Intervention/treatment |
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Experimental: SLIMM Intervention
Sit Less, Interact, Move More (SLIMM): instruction and monitoring feedback to promote decrease in sedentary activity duration, increase in casual walking duration, and increase in sedentary breaks
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Behavioral: Sit Less, Interact, Move More (SLIMM) |
No Intervention: Standard of Care
Subjects will receive standard of care treatment for chronic kidney disease, with no instruction or feedback to alter sedentary or casual walking durations
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- Change in Sedentary Activity Duration [ Time Frame: Baseline and 24 Weeks ]Change in sedentary activity duration (average sedentary minutes per hour), as measured by a validated accelerometry monitor from baseline to 24 weeks
- Change in Casual Walking Duration [ Time Frame: Baseline and 24 Weeks ]Change in casual walking activity duration (average walking minutes per hour), as measured by a validated accelerometry monitor from baseline to 24 weeks
- Change in Waist Circumference [ Time Frame: Baseline and 24 Weeks ]Change in waist circumference, measured in centimeters, from baseline to 24 weeks
- Change in Non-Exercise Activity Thermogenesis [ Time Frame: Baseline and 24 Weeks ]Change in non-exercise activity thermogenesis, measured in kilocalorie/kilogram/hour, from baseline to 24 weeks
- Change in Physical Function [ Time Frame: Baseline and 24 Weeks ]Change in walking distance, measured in meters, using the 6-minute walk test from baseline to 24 weeks

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Stage 3/4 Chronic Kidney Disease, as defined by estimated glomerular filtration rate (eGFR) 15 to < 60 ml/min/1.73m^2
- Body Mass Index (BMI): 25 to 39.9 kg/m^2
- Able to achieve gait speed of > 1 m/sec and able to walk ≥ 320 meters in the 6-minute walk test
Exclusion Criteria:
- Previous renal replacement therapy
- Life expectancy < 1 year
- Pregnancy
- Prison incarceration

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02970123
United States, Utah | |
University of Utah | |
Salt Lake City, Utah, United States, 84132 |
Principal Investigator: | Srinivasan Beddhu, M.D. | University of Utah |
Publications:
Responsible Party: | Srinvasan Beddhu, Principal Investigator, University of Utah |
ClinicalTrials.gov Identifier: | NCT02970123 |
Other Study ID Numbers: |
IRB_00093477 1R21DK106574-01A1 ( U.S. NIH Grant/Contract ) |
First Posted: | November 21, 2016 Key Record Dates |
Last Update Posted: | September 17, 2019 |
Last Verified: | September 2019 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Kidney Diseases Renal Insufficiency, Chronic Urologic Diseases Renal Insufficiency |