Effect of Pranayama on Periodontal Health
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|ClinicalTrials.gov Identifier: NCT02967861|
Recruitment Status : Completed
First Posted : November 18, 2016
Last Update Posted : November 18, 2016
|Condition or disease||Intervention/treatment||Phase|
|Chronic Periodontitis||Behavioral: Pranayama Procedure: Scaling and root planing||Early Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Effect of Pranayama on Peroxisome Proliferator-activated Receptor Gamma, Nuclear Factor Kappa B and Red Complex Microorganisms in Patients With Chronic Periodontitis|
|Study Start Date :||January 2016|
|Actual Primary Completion Date :||July 2016|
|Actual Study Completion Date :||July 2016|
Active Comparator: SRP & pranayama (lifestyle modification)
30 chronic periodontitis subjects treated with SRP & pranayama for 3 months
Pranayama is the breathing exercise through the nostrils. It enhances the systemic immunity which in turn enhances the overall defense mechanism of an individual.
Placebo Comparator: Scaling and root planing
30 chronic periodontitis subjects treated with scaling and root planing only
Procedure: Scaling and root planing
It is a mechanical debridement of dental plaque.
- Clinical efficacy of pranayama in chronic periodontitis patients from baseline to 3 months [ Time Frame: 3 months ]Clinical attachment level is measured using Williams periodontal probe in millimeters with the criteria of 1 to 2 mm for slight periodontitis, 3 to 4 mm for moderate periodontits and greater or equal to 5 mm for severe periodontitis.
- Microbiological efficacy of pranayama in chronic periodontitis patients from baseline to 3 months [ Time Frame: 3 months ]Red complex microorganisms such as P.gingivalis, T.denticola, T.forsythia are identified as '0' for absence and '1' for presence and analysed using polymerase chain reaction from subgingival plaque samples.
- Efficacy of pranayama on nuclear factor-kappa B (NF-kB) in chronic periodontitis patients [ Time Frame: 3 months ]The expression of NF-kB is analysed using Real time PCR after isolation of RNA from subgingival plaque samples.
- Efficacy of pranayama on perosxisome proliferator-activated receptor (PPAR)-γ in chronic periodontitis patients [ Time Frame: 3 months ]The expression of PPAR- γ is analysed using Real time PCR after isolation of RNA from subgingival plaque samples.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02967861
|Principal Investigator:||Jaideep Mahendra, MDS, Ph.D||Meenakshi Ammal Dental College & Hospital|