Effect of Topical Phenylephrine 2.5% on EVP in Normal Human Eyes
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|ClinicalTrials.gov Identifier: NCT02965924|
Recruitment Status : Completed
First Posted : November 17, 2016
Results First Posted : October 23, 2019
Last Update Posted : October 23, 2019
|Condition or disease||Intervention/treatment||Phase|
|Assess Phenylephrine on EVP and IOP||Drug: Phenylephrine 2.5%||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Effect of Topical Phenylephrine 2.5% on Episcleral Venous Pressure in Normal Human Eyes|
|Study Start Date :||October 2016|
|Actual Primary Completion Date :||October 1, 2018|
|Actual Study Completion Date :||October 1, 2018|
Subjects will receive topical phenylephrine 2.5% eye drop instilled in one eye after all baseline measurements.
Drug: Phenylephrine 2.5%
Instilling phenylephrine 2.5% eye drop
- Change in Episcleral Venous Pressure (EVP) [ Time Frame: baseline, 60 minutes ]EVP will be measured non-invasively using a custom-modified slit-lamp mounted venomanometer. This device utilizes the pressure chamber technique, in which a clear flexible balloon is placed against the conjunctival surface of the eye, and the pressure is increased until an episcleral vein is noted to blanch. The system for pressure-chamber based venomanometry includes a computer-controlled motor drive to increase pressure automatically, a transducer to record pressure, and a high-definition video camera to record vein collapse. Pressure measurements are synchronized with the video stream and image analysis software is used to determine the pressure required to collapse the vein to a specific pre-determined degree as measured in mmHg.
- Change in Intraocular Pressure (IOP) [ Time Frame: baseline, 60 minutes ]Intraocular pressure will be measured in mmHg after topical anesthesia by using the pneumatonometer. There will be a minimum of three IOP measurements and a mean will be accepted as IOP.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02965924
|United States, Minnesota|
|Mayo Clinic in Rochester|
|Rochester, Minnesota, United States, 55905|
|Principal Investigator:||Arthur J Sit, M.D.||Mayo Clinic|