Dynamic Changes of Circulating Tumor DNA in Surgical Lung Cancer Patients
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Previous study showed circulating tumor DNA levels reflect the total systemic tumor burden. Circulating tumor DNA levels should decrease after complete surgery and could be increase as tumor recurrence. Few study investigated the half time of circulating tumor DNA in lung cancer patients that no criterion has been established of how to use it for surveillance.
Condition or disease
CarcinomaNon-small-cell Lung CancerLung Neoplasms
For lung cancer patients who received surgery, multiple time of plasma will be collected before or after surgery. A series of mutations will be detected in plasma before surgery based on next generation sequencing. The positive mutation will be traced after surgery and in follow up.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Histologically confirmed lung cancer patients who received completely tumor resection
Suspected lung cancer before surgery
No malignant tumor history within the past 5 years
The pulmonary nodule is not pure ground glass opacity
Patients must have given written informed consent
Multiple primary lung cancer
Histology confirmed not non-small cell lung cancer