Effectiveness of Changing Dietary Fat on Weight Loss (HAWLS)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02953158|
Recruitment Status : Completed
First Posted : November 2, 2016
Last Update Posted : January 2, 2020
|Condition or disease||Intervention/treatment||Phase|
|Overweight||Other: Haas Avocado Behavioral: Dietary Counseling||Not Applicable|
Overweight and obesity in the United States and other industrialized countries represents a significant and growing health problem. Individuals who are overweight or obese increase their risk of coronary heart disease (CHD), diabetes (T2D), and the metabolic syndrome. Obesity affects both genders and every ethnicity in the United States. The prevalence of obesity in the United States is currently 32.2% in adult men and 35.5% in adult women. The most recent evidence indicates that 33.8% of adults, over 66 million American adults, are obese (30 million men and 36 million women) while an additional 74 million (42 million men and 32 million women) are overweight. The prevalence of obesity has grown a shocking 40% over the last 30 years.
These problems are truly global in nature. In European countries obesity ranges from 20-30% of the population and is even higher in Australia, South America, and Polynesia. The World Health Organization estimates that there will be over 1.5 billion obese individuals worldwide by 2020 if current trends continue.
Calorie controlled diets have routinely been demonstrated to help in both short and long-term weight reduction in individuals who are overweight or obese. In particular, hypocaloric diets, with a calorie reduction of 500 kcals per day have been shown in numerous studies to result in safe and effective weight loss.
It is important for individuals who are following weight loss programs to maintain healthy nutritional patterns, to maintain or improve their dietary quality. Haas avocados can play a significant role as part of a healthy weight loss program and help individuals not only improve their dietary quality, but also lower their risk of chronic diseases such as CHD, T2D, and the metabolic syndrome. Avocados are high in monounsaturated fat, dietary fiber, and a variety of other important phytochemicals such as lutein, vitamin E, niacin and folate. Despite these multiple nutritional benefits, myths exist that avocados may be fattening due to their fat and calorie content and therefore, should be avoided by people trying to lose weight.
The current research trial is designed to compare two energy reduced (hypocaloric) diets. One diet will include one Hass avocado/day, while achieving a 500 kcal/day energy reduction. The other diet will follow a usual American diet pattern, but will also include an energy restriction of 500 kcals/day. Parameters to be explored include weight loss, satiety, dietary quality, changes in body composition and risk factors for chronic disease.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||A Comparison of A Hypocaloric Diet Plus One Hass Avocado Per Day Versus An Equally Hypocaloric Diet for Weight Loss, Satiety, Changes in Body Composition, and Risk Factors for Chronic Disease (HAWLS)|
|Actual Study Start Date :||January 3, 2017|
|Actual Primary Completion Date :||December 20, 2017|
|Actual Study Completion Date :||December 20, 2017|
Experimental: Haas Avocado
Haas Avocado commercially available Behavioral: Dietary recommendations Recommendation: a hypocaloric weight loss diet
Other: Haas Avocado
Hypocaloric weight loss diet
Other Name: Avocado
Active Comparator: Dietary Counseling
Behavioral: Dietary Counseling Recommendation: equally hypocaloric usual American diet.
Behavioral: Dietary Counseling
- Change in weight loss after consumption of 1 Haas Avocado per day with a hypocaloric diet [ Time Frame: Baseline to 12 weeks ]Individuals will be randomly assigned to a hypocaloric (500 Cal deficit) meal plans with or without one Hass avocado a day for 12 weeks.
- Change in gut microbiome [ Time Frame: Baseline to 12 weeks ]Individuals will be randomly assigned to a hypocaloric (500 Cal deficit) meal plans with or without one Hass avocado a day for 12 weeks.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02953158
|United States, California|
|UCLA Center for Human Nutrition|
|Los Angeles, California, United States, 90024|
|Principal Investigator:||Zhaoping Li, MD, PhD||UCLA Center for Human Nutrition|