Active Surveillance of Papillary Thyroid Microcarcinoma
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ClinicalTrials.gov Identifier: NCT02952612
Recruitment Status : Unknown
Verified November 2016 by Dong Jun Lim, Seoul St. Mary's Hospital. Recruitment status was: Recruiting
Papillary thyroid microcarcinoma are small thyroid cancer measuring 1cm or less. Most of this tumor are not palpable and are identified either through pathologic examination or from imaging modalities, such as CT scan or thyroid sono. Active surveillance of papillary microcarcinoma is to observe thyroid papillary cancer without immediate surgical approach. The purpose of this study is to understand more about the characteristics of papillary microcarcinoma, which has been known for "the cancer slowly progression"
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
This observational study enrolls patients who was diagnosed as papillary thyroid microcarcinoma by FNA (Fine needle aspiration) or CNA(Core needle aspiration) and who wish to be enrolled this study.
< 1 cm solitary nodule
Surrounded by ≥ 2 mm normal thyroid parenchyma
Subcapsular locations not adjacent to surrounding structures, recurrent laryngeal nerve, trachea, or carotid artery
No evidence of invasion to surrounding structures, recurrent laryngeal nerve, trachea or carotid artery
No extrathyroidal extension
Clinically N0 and Clinically M0
≥ 18 years
Combined severe comorbidities or Inoperable condition (optional)
No wish to surgery and Willingness to accept active surveillance
No history of radiotherapy on head and neck area
Accepted by the Board of Thyroid Cancer Meeting
≥ 1 cm nodule and multifocal nodules regardless of size
Papillary thyroid carcinoma variants associated with poor prognosis (tall cell variant, columnar variant, hobnail variant) or other types of thyroid cancer)
Subcapsular locations adjacent to surrounding structures, recurrent laryngeal nerve, trachea or carotid artery
Evidence of invasion to surrounding structures, recurrent laryngeal nerve, trachea or carotid artery
Any of N1 or M1
Documented increase in size according to America Thyroid Association (ATA) guideline in a previously confirmed Papillary thyroid microcarcinoma
< 18 years
Not willing to accept observational active surveillance approach