Neural Mechanisms for Appetitive Responses to High Reward Foods
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|ClinicalTrials.gov Identifier: NCT02945475|
Recruitment Status : Completed
First Posted : October 26, 2016
Last Update Posted : April 20, 2021
|Condition or disease|
|Appetitive Behavior Obesity|
|Study Type :||Observational|
|Actual Enrollment :||114 participants|
|Official Title:||Neural Mechanisms for Appetitive Responses to High Reward Foods|
|Study Start Date :||February 2016|
|Actual Primary Completion Date :||March 13, 2020|
|Actual Study Completion Date :||March 13, 2020|
Individuals ages 18 to 35 years of age with body mass index (BMI) 30-40 kg/m2
Individuals ages 18 to 35 years of age with BMI of 19-24.9 kg/m2
Individuals ages 18 to 35 years of age with BMI of 25-29.9 kg/m2
- Changes of Blood oxygen level-dependent (BOLD) signal responses to food vs non-food cues after ingestion of different types of sugar. BOLD signal responses to food cues will be compared at the level of whole brain and within a priori regions of interest. [ Time Frame: Sessions 1, 2, 3, 4 ]These will be compared between ingestion of drinks and at level of whole brain and in regions of interest
- Cerebral Blood Flow Response [ Time Frame: Sessions 1, 2, 3, 4 ]Arterial spin labeling with be used to determine brain areas with relative increases or decreases in CBF after ingestion of sucrose, glucose, or sucralose.
- Systemic Metabolite and Hormone Responses [ Time Frame: Sessions 1, 2, 3, 4 ]The effects of sugar ingestion on changes in systemic metabolite (glucose) and hormone (insulin, GLP-1, leptin, ghrelin, peptide YY) levels will be assessed.
- Functional Connectivity between regions involved in regulation of food intake [ Time Frame: Sessions 1, 2, 3, 4 ]Investigators will perform a physiological-psychological-interaction (PPI) analysis using the nucleus accumbens as the seed to explore brain regions showing increased functional connectivity to the seed during the food-cue task.
- Appetite Ratings [ Time Frame: Sessions 1, 2, 3, 4 ]Ratings of hunger and desire for food in response to food vs non-food cues will be analyzed using a repeated-measures ANOVA with condition (glucose, sucrose, sucralose) and stimulus (food vs non-food) as within-subject factors.
- Ad Libitum Food Intake [ Time Frame: Sessions 1, 2, 3, 4 ]Total calories consumed and percent calories from sugar, fat and protein will be compared between conditions.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02945475
|United States, California|
|Los Angeles, California, United States, 90089|
|Principal Investigator:||Kathleen Page, MD||University of Southern California|