Study to Assess the Safety and Efficacy of Ribociclib (LEE011) in Combination With Letrozole for the Treatment of Men and Pre/Postmenopausal Women With HR+ HER2- aBC
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT02941926 |
Recruitment Status :
Active, not recruiting
First Posted : October 21, 2016
Last Update Posted : October 6, 2020
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Breast Cancer | Drug: Ribociclib Drug: Letrozole Drug: Goserelin Drug: Leuprolide | Phase 3 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 3255 participants |
Allocation: | N/A |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | COMPLEEMENT-1: An Open-label, Multicenter, Phase IIIb Study to Assess the Safety and Efficacy of Ribociclib (LEE011) in Combination With Letrozole for the Treatment of Men and Pre/Postmenopausal Women With Hormone Receptor-positive (HR+) HER2-negative (HER2-) Advanced Breast Cancer (aBC) With no Prior Hormonal Therapy for Advanced Disease |
Actual Study Start Date : | November 30, 2016 |
Actual Primary Completion Date : | November 8, 2019 |
Estimated Study Completion Date : | May 8, 2021 |

Arm | Intervention/treatment |
---|---|
Experimental: Ribociclib + letrozole
Ribociclib oral (3 weeks on/1 week off) in combination with oral once daily letrozole: 600 mg ribociclib QD + 2.5 mg letrozole QD
|
Drug: Ribociclib
Ribociclib oral (3 weeks on/1 week off), 600 mg ribociclib QD
Other Name: LEE011 Drug: Letrozole Oral once daily, 2.5 mg letrozole QD Drug: Goserelin Only for men and premenopausal women: administered as an injectable subcutaneous implant once every 28 days Drug: Leuprolide Only for men and premenopausal women: administered as an injectable intramuscular depot once every 28 days |
- The number of participants with adverse events as a measure of safety and tolerability [ Time Frame: Up to approximately 36 months ]AEs, Grade 3/4 AEs & SAEs during treatment with ribociclib + letrozole
- Time-to-Progression (TTP) [ Time Frame: Up to approximately 36 months ]Time to progression (TTP) is defined as time from date of start of treatment to the date of event defined as the first documented progression or death due to underlying cancer.
- Overall response rate (ORR) for patients with measurable disease [ Time Frame: Up to approximately 36 months ]Overall response rate (ORR) is defined as the proportion of patients with best overall response of complete response (CR) or partial response (PR) according to RECIST 1.1.
- Clinical Benefit Rate (CBR) [ Time Frame: Up to approximately 36 months ]Clinical benefit rate (CBR) is defined as the proportion of patients with a best overall response of complete response (CR), or partial response (PR) or an overall lesion response of stable disease (SD), lasting as per local review, for a duration of at least 24 weeks. CR, PR and SD are defined according to RECIST 1.1.
- Patient Reported Outcome (PRO) using scores from FACT-B questionaire [ Time Frame: Up to approximately 36 months ]FACT-B questionnaire will be used to collect patient reported outcome data in this trial. Descriptive statistics will be used to summarize the subscale and overall scores at each scheduled assessment time point. Additionally, change from baseline at the time of each assessment will be summarized. PRO data may be summarized by country/region.
- The number of participants with adverse events as a measure of safety and tolerability during Extension Phase [ Time Frame: Up to approximatley 18 months ]Frequency and severity of AEs and SAEs
- Percentage of patients with clinical benefit during Extension Phase [ Time Frame: Up to approximately 18 months ]Clinical benefit is assessed by investigator

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Male or female advanced (locoregionally recurrent or metastatic) breast cancer not amenable to curative therapy.
-
In the case of women, both pre/perimenopausal and postmenopausal patients are allowed to be included in this study; menopausal status is relevant for the requirement of goserelin to be used concomitantly with ribociclib and letrozole.
-
Postmenopausal status is defined either by:
I). Prior bilateral oophorectomy OR ii). Age ≥ 60 OR iii). Age < 60 and amenorrhea for 12 or more months (in the absence of chemotherapy, tamoxifen, toremifen, or ovarian suppression) and FSH and estradiol in the postmenopausal range per local normal range. If patient is taking tamoxifen or toremifene and age < 60, then FSH and plasma estradiol levels should be in post-menopausal range per local normal range (NCCN Guidelines version 2.2017).
Note: For women with therapy-induced amenorrhea, serial measurements of FSH and/or estradiol are needed to ensure menopausal status.
-
Premenopausal status is defined as either:
I). Patient had last menstrual period within the last 12 months, OR ii). If on tamoxifen or toremifene within the past 14 days, plasma estradiol and FSH must be in the premenopausal range per local normal range, OR iii). In case of therapy induced amenorrhea, plasma estradiol and/or FSH must be in the premenopausal range per local normal range.
- Perimenopausal status is define as neither premenopausal nor postmenopausal Note: Throughout this document, perimenopausal and premenopausal status is grouped together and referred as "Premenopausal"
-
- Patient has a histologically and/or cytologically confirmed diagnosis of estrogen-receptor positive and/or progesterone receptor positive breast cancer by local laboratory.
- Patient has HER2-negative breast cancer defined as a negative in situ hybridization test or an IHC status of 0, 1+ or 2+. If IHC is 2+, a negative in situ hybridization (FISH, CISH, or SISH) test is required by local laboratory testing.
- Patient has an Eastern Cooperative Oncology Group (ECOG) performance status ≤2
-
Patient has adequate bone marrow and organ function as defined by ALL of the following laboratory values (as assessed by local laboratory):
- Absolute neutrophil count ≥ 1.5 × 10^9/L
- Platelets ≥ 100 × 10^9/L
- Hemoglobin ≥ 9.0 g/dL
- Potassium, sodium, calcium corrected for serum albumin and magnesium within normal limits or corrected to within normal limits with supplements before first dose of the study medication
- INR ≤1.5
- Serum creatinine <1.5 mg/dl or creatinine clearance≥50 mL/min
- In absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) should be below 2.5 × ULN. If the patient has liver metastases, ALT and AST should be < 5 × ULN.
- Total serum bilirubin < ULN; or total bilirubin ≤ 3.0 × ULN with direct bilirubin within normal range in patients with well-documented Gilbert's Syndrome
-
Patient must have a 12-lead ECG with ALL of the following parameters at screening:
- QTcF interval at screening <450 msec (using Fridericia's correction)
- Resting heart rate ≥ 50 bpm
Exclusion Criteria:
- Patient who received any CDK4/6 inhibitor
- Patient who received any prior systemic hormonal therapy for advanced breast cancer; no more than one prior regimen of chemotherapy for the treatment of metastatic disease is permitted
Note:
- Patients who received (neo) adjuvant therapy for breast cancer are eligible. If the prior neo (adjuvant) therapy included letrozole or anastrozole the disease free interval must be greater than 12 months from the completion of treatment until study entry.
- Patients who received ≤ 28 days of letrozole or anastrozole for advanced disease prior to inclusion in this trial are eligible.
-
Any prior (neo) adjuvant anti-cancer therapy or prior chemotherapy for metastatic disease must be stopped at least 5 half-lives or 7 days, whichever is longer, before study inclusion.
- Patient is concurrently using other anti-cancer therapy.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02941926


United States, Alaska | |
Alaska Cancer Research and Education Center | |
Anchorage, Alaska, United States, 99508 | |
United States, Arizona | |
Ironwood Cancer and Research Centers | |
Chandler, Arizona, United States, 85224 | |
Arizona Oncology Associates | |
Phoenix, Arizona, United States | |
Arizona Oncology Associates Arizona Oncology Assoc. (2) | |
Tucson, Arizona, United States, 85745 | |
United States, Arkansas | |
Highlands Oncology Group | |
Fayetteville, Arkansas, United States, 72703 | |
United States, California | |
Beverly Hills Cancer Center | |
Beverly Hills, California, United States, 90211 | |
Pacific Shores Medical Group SC | |
Long Beach, California, United States, 90813 | |
USC Norris Cancer Center | |
Los Angeles, California, United States, 90033 | |
University of California Irvine UC Irvine (11) | |
Orange, California, United States, 92868 | |
Ventura County Hematology and Oncology | |
Oxnard, California, United States, 93030 | |
PCR Oncology | |
Pismo Beach, California, United States, 93449 | |
California Pacific Medical Center Onc Dept | |
San Francisco, California, United States, 94120-7999 | |
United States, Colorado | |
Centura Health Research Center Centura Health Research Center | |
Denver, Colorado, United States, 80210 | |
Poudre Valley Hospital Poudre Valley Health System | |
Fort Collins, Colorado, United States, 80528 | |
Valley View Hospital Cancer Center | |
Glenwood Springs, Colorado, United States, 81601 | |
United States, Florida | |
Foundation for Sickle Cell Disease Research | |
Hollywood, Florida, United States, 33021 | |
Watson Clinic Center for Research 1730 Location | |
Lakeland, Florida, United States, 33805 | |
Mid Florida Hematology and Oncology Center | |
Orange City, Florida, United States, 32763 | |
United States, Georgia | |
Summit Cancer Care Summit Cancer Care (SC) | |
Savannah, Georgia, United States, 31405 | |
John D Archbold Memorial Hospital John D. Archbold Mem Hosp (4) | |
Thomasville, Georgia, United States, 31792 | |
United States, Idaho | |
Saint Alphonsus Regional Medical Center | |
Boise, Idaho, United States, 83706 | |
United States, Illinois | |
Stroger Cook County Hospital Division of Hematology & Onc | |
Chicago, Illinois, United States, 60612 | |
Joliet Oncology-Hematology Associates Presence Cancer Center | |
Joliet, Illinois, United States, 60435 | |
Mid Illinois Hematology Oncology Mid Illinois Hema/Onc (3) | |
Normal, Illinois, United States, 61761 | |
Alpha Med Physician Group, LLC | |
Tinley Park, Illinois, United States, 60487 | |
United States, Indiana | |
Indiana University Health Goshen Center for Cancer SC | |
Goshen, Indiana, United States, 46526 | |
Northwest Oncology | |
Munster, Indiana, United States, 46321 | |
United States, Iowa | |
June E. Nylan Cancer Center | |
Sioux City, Iowa, United States, 51101 | |
United States, Kansas | |
University of Kansas Cancer Center University of Kansas Med Ctr 9 | |
Kansas City, Kansas, United States, 66160 | |
Sarah Cannon at Overland Park Regional Medical Center | |
Overland Park, Kansas, United States, 66209 | |
United States, Louisiana | |
John Ochsner Heart and Vascular Institute Clinical Trials | |
New Orleans, Louisiana, United States, 70121 | |
United States, Maine | |
Mercy Oncology / Hematology Center SC | |
Portand, Maine, United States, 04102 | |
United States, Maryland | |
Greater Baltimore Medical Center Cancer Center Greater Baltimore Medical Ctr | |
Baltimore, Maryland, United States, 21204-6831 | |
Maryland Oncology Hematology, P.A. Columbia | |
Rockville, Maryland, United States, 20850 | |
Kaiser Permanente | |
Rockville, Maryland, United States, 20879 | |
Medical Faculty Assc Inc Medical Faculty Assc., Inc. (2 | |
Washington DC, Maryland, United States, 20037 | |
United States, Mississippi | |
Jackson Oncology Associates | |
Jackson, Mississippi, United States, 39202 | |
United States, Nebraska | |
Nebraska Hematology-Oncology, P.C. | |
Lincoln, Nebraska, United States, 68506 | |
Nebraska Cancer Specialists Oncology Hematology West | |
Omaha, Nebraska, United States, 68154 | |
United States, Nevada | |
Comprehensive Cancer Centers of Nevada CCC of Nevada Henderson (4) | |
Las Vegas, Nevada, United States, 89109 | |
United States, New Jersey | |
Trinitas Comprehensive Cancer Center | |
Elizabeth, New Jersey, United States, 07207 | |
Englewood Hospital and Medical Center | |
Englewood, New Jersey, United States, 07631 | |
The Valley Hospital / Luckow Pavillion | |
Paramus, New Jersey, United States, 07652 | |
Somerset Hematology Oncology Associates Somerset Hematolgy Onc -MI | |
Somerset, New Jersey, United States, 08873 | |
United States, New Mexico | |
New Mexico Cancer Care Alliance | |
Albuquerque, New Mexico, United States, 87106 | |
San Juan Oncology Associates | |
Farmington, New Mexico, United States, 87401 | |
United States, New York | |
Eastchester Center for Cancer Care | |
Bronx, New York, United States, 10469 | |
Clinical Research Alliance | |
Lake Success, New York, United States, 11042 | |
United States, North Carolina | |
Oncology Speciialists of Charlotte | |
Charlotte, North Carolina, United States, 28207 | |
United States, Ohio | |
Aultman Hospital | |
Canton, Ohio, United States, 44710 | |
The Christ Hospital Cancer Center Research Program Linder Research Center | |
Cincinnati, Ohio, United States, 45219 | |
University Hospitals of Cleveland Seidman Cancer Center Cleveland Medical Center | |
Cleveland, Ohio, United States, 44106 | |
Cleveland Clinic Cleveland Clinic (5) | |
Cleveland, Ohio, United States, 44195 | |
Dayton Physicians | |
Kettering, Ohio, United States, 45409 | |
United States, Oklahoma | |
Oklahoma Cancer Specialists and Research Institute SC-2 | |
Tulsa, Oklahoma, United States, 74136 | |
United States, Oregon | |
Oregon Health and Science University SC-5 | |
Portland, Oregon, United States, 97239 | |
United States, South Carolina | |
McLeod Center for Cancer Treatment and Research | |
Florence, South Carolina, United States, 29506 | |
Carolina Blood and Cancer Care of South Carolina | |
Rock Hill, South Carolina, United States, 29732 | |
United States, Texas | |
Millennium Oncology Millennium Oncology - FL | |
Houston, Texas, United States, 77090 | |
Cancer Therapy and Research Center UT Health Science Center | |
San Antonio, Texas, United States, 78229 | |
Hope Cancer Center of East Texas | |
Tyler, Texas, United States, 75701 | |
United States, Virginia | |
Virginia Oncology Associates | |
Norfolk, Virginia, United States, 23502 | |
United States, Washington | |
PeaceHealth St Joseph Medical Center | |
Bellingham, Washington, United States, 98225 | |
Providence Regional Medical Centre of Everett | |
Everett, Washington, United States, 98201 | |
Kadlec Clinic Hematology and Oncology | |
Kennewick, Washington, United States, 99336 | |
Valley Medical Center Research Valley Medical Center | |
Renton, Washington, United States, 98055 | |
Virginia Mason Medical Center-Oncology SC | |
Seattle, Washington, United States, 98101 | |
Northwest Medical Specialties Dept.ofNW Med. Specialties | |
Tacoma, Washington, United States, 98405 | |
United States, Wisconsin | |
Columbia St Mary s Hospital of Milwaukee St. Mary's Hospital Ozaukee | |
Milwaukee, Wisconsin, United States, 53211 | |
United States, Wyoming | |
Cheyenne Regional Medical Center Cheyenne Regional Med Ctr (3) | |
Cheyenne, Wyoming, United States, 82001 | |
Argentina | |
Novartis Investigative Site | |
Caba, Buenos Aires, Argentina, C1125ABD | |
Novartis Investigative Site | |
Caba, Buenos Aires, Argentina, C1426ANZ | |
Novartis Investigative Site | |
Rosario, Santa Fe, Argentina, S2000KZE | |
Novartis Investigative Site | |
San Miguel De Tucuman, Tucuman, Argentina, T4000IAK | |
Novartis Investigative Site | |
La Rioja, Argentina, 5300 | |
Austria | |
Novartis Investigative Site | |
Innsbruck, Tyrol, Austria, 6020 | |
Novartis Investigative Site | |
Graz, Austria, 8036 | |
Novartis Investigative Site | |
Leoben, Austria, A 8700 | |
Novartis Investigative Site | |
Rankweil, Austria, A-6830 | |
Novartis Investigative Site | |
Salzburg, Austria, 5020 | |
Novartis Investigative Site | |
Vienna, Austria, 1090 | |
Novartis Investigative Site | |
Vienna, Austria, A-1090 | |
Novartis Investigative Site | |
Wien, Austria, A-1130 | |
Belgium | |
Novartis Investigative Site | |
Sint Niklaas, Vlaams Brabant, Belgium, 9100 | |
Novartis Investigative Site | |
Antwerp, Belgium, 2020 | |
Novartis Investigative Site | |
Bonheiden, Belgium, 2820 | |
Novartis Investigative Site | |
Brugge, Belgium, 8000 | |
Novartis Investigative Site | |
Brussels, Belgium, BE-B-1200 | |
Novartis Investigative Site | |
Brussel, Belgium, 1090 | |
Novartis Investigative Site | |
Bruxelles, Belgium, 1000 | |
Novartis Investigative Site | |
Charleroi, Belgium, 6000 | |
Novartis Investigative Site | |
Genk, Belgium, 3600 | |
Novartis Investigative Site | |
Gent, Belgium, 9000 | |
Novartis Investigative Site | |
Hasselt, Belgium, 3500 | |
Novartis Investigative Site | |
Kortrijk, Belgium, 8500 | |
Novartis Investigative Site | |
Leuven, Belgium, 3000 | |
Novartis Investigative Site | |
Liege, Belgium, 4000 | |
Novartis Investigative Site | |
Luxembourg, Belgium, 1210 | |
Novartis Investigative Site | |
Mons, Belgium, 7000 | |
Novartis Investigative Site | |
Namur, Belgium, 5000 | |
Novartis Investigative Site | |
Roeselare, Belgium, 8800 | |
Novartis Investigative Site | |
Verviers, Belgium, 4800 | |
Novartis Investigative Site | |
Wilrijk, Belgium, 2610 | |
Bulgaria | |
Novartis Investigative Site | |
Gabrovo, Bulgaria, 5300 | |
Novartis Investigative Site | |
Plovdiv, Bulgaria, 4004 | |
Novartis Investigative Site | |
Sofia, Bulgaria, 1303 | |
Novartis Investigative Site | |
Sofia, Bulgaria, 1527 | |
Novartis Investigative Site | |
Sofia, Bulgaria, 1606 | |
Novartis Investigative Site | |
Sofia, Bulgaria, 1756 | |
Canada, Alberta | |
Novartis Investigative Site | |
Calgary, Alberta, Canada, T2N 4N2 | |
Novartis Investigative Site | |
Edmonton, Alberta, Canada, T6G 1Z2 | |
Canada, British Columbia | |
Novartis Investigative Site | |
Kelowna, British Columbia, Canada, V1Y 5L3 | |
Novartis Investigative Site | |
Surrey, British Columbia, Canada, V3V 1Z2 | |
Novartis Investigative Site | |
Vancouver, British Columbia, Canada, V5Z 4E6 | |
Canada, Manitoba | |
Novartis Investigative Site | |
Winnipeg, Manitoba, Canada, R3E 0V9 | |
Canada, New Brunswick | |
Novartis Investigative Site | |
Moncton, New Brunswick, Canada, E1C 6Z8 | |
Canada, Nova Scotia | |
Novartis Investigative Site | |
Halifax, Nova Scotia, Canada, B3H 2Y9 | |
Canada, Ontario | |
Novartis Investigative Site | |
Barrie, Ontario, Canada, L4M 6M2 | |
Novartis Investigative Site | |
Cambridge, Ontario, Canada, N1R 3G2 | |
Novartis Investigative Site | |
Hamilton, Ontario, Canada, L8V 5C2 | |
Novartis Investigative Site | |
Kingston, Ontario, Canada, K7L 5P9 | |
Novartis Investigative Site | |
Kitchener, Ontario, Canada, N2G 1G3 | |
Novartis Investigative Site | |
London, Ontario, Canada, N6A 4G4 | |
Novartis Investigative Site | |
Newmarket, Ontario, Canada, L3Y 2P9 | |
Novartis Investigative Site | |
North York, Ontario, Canada, M2K1E1 | |
Novartis Investigative Site | |
Oshawa, Ontario, Canada, L1G 2B9 | |
Novartis Investigative Site | |
Ottawa, Ontario, Canada, KIH 7W9 | |
Novartis Investigative Site | |
Sault Ste Marie, Ontario, Canada, P6B 0A8 | |
Novartis Investigative Site | |
Sudbury, Ontario, Canada, P3E 5J1 | |
Novartis Investigative Site | |
Toronto, Ontario, Canada, M3M 0B2 | |
Novartis Investigative Site | |
Toronto, Ontario, Canada, M4N 3M5 | |
Novartis Investigative Site | |
Toronto, Ontario, Canada, M5B 1W8 | |
Canada, Quebec | |
Novartis Investigative Site | |
Greenfield Park, Quebec, Canada, J4V 2H1 | |
Novartis Investigative Site | |
Laval, Quebec, Canada, H7M 3L9 | |
Novartis Investigative Site | |
Montreal, Quebec, Canada, H3T 1E2 | |
Novartis Investigative Site | |
Montreal, Quebec, Canada, H3T 1M5 | |
Novartis Investigative Site | |
Montreal, Quebec, Canada, H4J 1C5 | |
Novartis Investigative Site | |
Sherbrooke, Quebec, Canada, J1H 5N4 | |
Canada, Saskatchewan | |
Novartis Investigative Site | |
Regina, Saskatchewan, Canada, S4T 7T1 | |
Novartis Investigative Site | |
Saskatoon, Saskatchewan, Canada, S7N 4H4 | |
Canada | |
Novartis Investigative Site | |
Quebec, Canada, G1S 4L8 | |
Chile | |
Novartis Investigative Site | |
Santiago, Chile, 8420383 | |
Czechia | |
Novartis Investigative Site | |
Brno, Czech Republic, Czechia, 656 53 | |
Novartis Investigative Site | |
Liberec, Czech Republic, Czechia, 46063 | |
Novartis Investigative Site | |
Prague 8, Czech Republic, Czechia, 180 00 | |
Novartis Investigative Site | |
Zlin, Czech Republic, Czechia, 762 75 | |
Novartis Investigative Site | |
Hradec Kralove, CZE, Czechia, 500 05 | |
Novartis Investigative Site | |
Olomouc, CZE, Czechia, 775 20 | |
Novartis Investigative Site | |
Brno, Czechia, 625 00 | |
Novartis Investigative Site | |
Ceske Budejovice, Czechia, 370 87 | |
Novartis Investigative Site | |
Pardubice, Czechia, 532 03 | |
Novartis Investigative Site | |
Prague 5, Czechia, 150 00 | |
Novartis Investigative Site | |
Praha 10, Czechia, 100 34 | |
Novartis Investigative Site | |
Praha 4, Czechia, 140 59 | |
Novartis Investigative Site | |
Praha, Czechia, 12808 | |
Denmark | |
Novartis Investigative Site | |
Copenhagen, Denmark, DK-2100 | |
Novartis Investigative Site | |
Vejle, Denmark, 7100 | |
Finland | |
Novartis Investigative Site | |
Helsinki, Finland, 00029 | |
Novartis Investigative Site | |
Oulu, Finland, FIN-90220 | |
Novartis Investigative Site | |
Tampere, Finland, FIN-33521 | |
France | |
Novartis Investigative Site | |
Nice Cedex 2, Alpes Maritimes, France, 06189 | |
Novartis Investigative Site | |
Dijon Cedex, Cote D Or, France, 21034 | |
Novartis Investigative Site | |
Limoges cedex, Haute Vienne, France, 87000 | |
Novartis Investigative Site | |
Saint-Cloud, Hauts De Seine, France, 92210 | |
Novartis Investigative Site | |
Tours Cedex 9, Indre Et Loire, France, 37044 | |
Novartis Investigative Site | |
Reims Cedex, Marne, France, 51056 | |
Novartis Investigative Site | |
Albi, France, 81000 | |
Novartis Investigative Site | |
Angers Cedex 02, France, 49055 | |
Novartis Investigative Site | |
Avignon Cedex, France, 84082 | |
Novartis Investigative Site | |
Besancon Cedex, France, 25030 | |
Novartis Investigative Site | |
Bobigny Cedex, France, 93009 | |
Novartis Investigative Site | |
Bordeaux Cedex, France, 33000 | |
Novartis Investigative Site | |
Bordeaux, France, 33076 | |
Novartis Investigative Site | |
Caen Cedex, France, 14021 | |
Novartis Investigative Site | |
Clermont-Ferrand, France, 63011 | |
Novartis Investigative Site | |
Colmar Cedex, France, 68024 | |
Novartis Investigative Site | |
Corbeil Essonnes, France, 91100 | |
Novartis Investigative Site | |
Creteil, France, 94010 | |
Novartis Investigative Site | |
Le Mans Cedex, France, 72015 | |
Novartis Investigative Site | |
Lille Cedex, France, 59020 | |
Novartis Investigative Site | |
Limoges, France, 87000 | |
Novartis Investigative Site | |
Lyon Cedex 08, France, 69373 | |
Novartis Investigative Site | |
Lyon Cedex, France, 69373 | |
Novartis Investigative Site | |
Marseille, France, 13273 | |
Novartis Investigative Site | |
Mont de Marsan cedex, France, 40024 | |
Novartis Investigative Site | |
Montpellier Cedex 5, France, 34298 | |
Novartis Investigative Site | |
Montpellier, France, 34070 | |
Novartis Investigative Site | |
Nancy, France, 54000 | |
Novartis Investigative Site | |
Nantes Cedex, France, 44277 | |
Novartis Investigative Site | |
Paris Cedex 13, France, 75651 | |
Novartis Investigative Site | |
Paris, France, 75010 | |
Novartis Investigative Site | |
Paris, France, 75012 | |
Novartis Investigative Site | |
Paris, France, 75231 | |
Novartis Investigative Site | |
Paris, France, 75970 | |
Novartis Investigative Site | |
Pierre Benite, France, 69310 | |
Novartis Investigative Site | |
Plerin Sur Mer, France, 22190 | |
Novartis Investigative Site | |
Périgueux Cédex, France, 24004 | |
Novartis Investigative Site | |
Reims, France, 51100 | |
Novartis Investigative Site | |
Rouen Cedex 1, France, 76038 | |
Novartis Investigative Site | |
Saint Herblain cedex, France, 44805 | |
Novartis Investigative Site | |
Strasbourg Cedex, France, 67010 | |
Novartis Investigative Site | |
Strasbourg Cedex, France, 67091 | |
Novartis Investigative Site | |
Toulon La Seyne Sur Mer, France, 83056 | |
Novartis Investigative Site | |
Troyes, France, 10003 | |
Novartis Investigative Site | |
Vandoeuvre-les-Nancy cedex, France, 54519 | |
Greece | |
Novartis Investigative Site | |
Ioannina, GR, Greece, 455 00 | |
Novartis Investigative Site | |
Thessaloniki, GR, Greece, 54645 | |
Novartis Investigative Site | |
Athens, Greece, 115 28 | |
Novartis Investigative Site | |
Athens, Greece, GR 115 22 | |
Novartis Investigative Site | |
Athens, Greece, GR14564 | |
Novartis Investigative Site | |
Patras, Greece, 265 00 | |
Novartis Investigative Site | |
Thessaloniki, Greece, 540 07 | |
Hong Kong | |
Novartis Investigative Site | |
Hong Kong, Hong Kong | |
Novartis Investigative Site | |
Kowloon, Hong Kong | |
Novartis Investigative Site | |
Pokfulam, Hong Kong | |
Hungary | |
Novartis Investigative Site | |
Budapest, Hungary, 1134 | |
Novartis Investigative Site | |
Budapest, Hungary, H 1122 | |
Novartis Investigative Site | |
Budapest, Hungary, H-1032 | |
Novartis Investigative Site | |
Debrecen, Hungary, 4032 | |
Novartis Investigative Site | |
Szeged, Hungary, 6725 | |
India | |
Novartis Investigative Site | |
Hyderabad, Andhra Pradesh, India, 500 034 | |
Novartis Investigative Site | |
Tamil Nadu, Chennai, India, 600035 | |
Novartis Investigative Site | |
New Delhi, Delhi, India, 110092 | |
Novartis Investigative Site | |
Admedabad, Gujarat, India, 380060 | |
Novartis Investigative Site | |
Bangalore, Karnataka, India, 560027 | |
Novartis Investigative Site | |
Nashik, Maharashtra, India, 422 004 | |
Novartis Investigative Site | |
Pune, Maharashtra, India, 411013 | |
Novartis Investigative Site | |
Jaipur, Rajasthan, India, 302017 | |
Novartis Investigative Site | |
Vellore, Tamil Nadu, India, 632 004 | |
Novartis Investigative Site | |
Kolkata, West Bengal, India, 700160 | |
Novartis Investigative Site | |
Delhi, India, 110 085 | |
Israel | |
Novartis Investigative Site | |
Beer-Sheva, Israel, 8457108 | |
Novartis Investigative Site | |
Haifa, Israel, 3525408 | |
Novartis Investigative Site | |
Jerusalem, Israel, 91120 | |
Novartis Investigative Site | |
Petach Tikva, Israel, 49100 | |
Novartis Investigative Site | |
Ramat Gan, Israel, 52621 | |
Novartis Investigative Site | |
Tel Aviv, Israel, 6423906 | |
Italy | |
Novartis Investigative Site | |
Alessandria, AL, Italy, 15100 | |
Novartis Investigative Site | |
Ancona, AN, Italy, 60126 | |
Novartis Investigative Site | |
L'Aquila, AQ, Italy, 67100 | |
Novartis Investigative Site | |
Arezzo, AR, Italy, 52100 | |
Novartis Investigative Site | |
Asti, AT, Italy, 14100 | |
Novartis Investigative Site | |
Avellino, AV, Italy, 83100 | |
Novartis Investigative Site | |
Bari, BA, Italy, 70124 | |
Novartis Investigative Site | |
Bergamo, BG, Italy, 24127 | |
Novartis Investigative Site | |
Treviglio, BG, Italy, 24047 | |
Novartis Investigative Site | |
Benevento, BN, Italy, 82100 | |
Novartis Investigative Site | |
Bologna, BO, Italy, 40139 | |
Novartis Investigative Site | |
Brindisi, BR, Italy, 72100 | |
Novartis Investigative Site | |
Brescia, BS, Italy, 25123 | |
Novartis Investigative Site | |
Brescia, BS, Italy, 25124 | |
Novartis Investigative Site | |
Monserrato, CA, Italy, 09042 | |
Novartis Investigative Site | |
Cuneo, CN, Italy, 12100 | |
Novartis Investigative Site | |
Cremona, CR, Italy, 26100 | |
Novartis Investigative Site | |
Catania, CT, Italy, 95124 | |
Novartis Investigative Site | |
Cona, FE, Italy, 44100 | |
Novartis Investigative Site | |
San Giovanni Rotondo, FG, Italy, 71013 | |
Novartis Investigative Site | |
Firenze, FI, Italy, 50134 | |
Novartis Investigative Site | |
Genova, GE, Italy, 16132 | |
Novartis Investigative Site | |
Grosseto, GR, Italy, 58100 | |
Novartis Investigative Site | |
Lecco, LC, Italy, 23900 | |
Novartis Investigative Site | |
Livorno, LI, Italy, 57124 | |
Novartis Investigative Site | |
Lucca, LU, Italy, 55100 | |
Novartis Investigative Site | |
Monza, MB, Italy, 20900 | |
Novartis Investigative Site | |
Macerata, MC, Italy, 62100 | |
Novartis Investigative Site | |
Messina, ME, Italy, 98158 | |
Novartis Investigative Site | |
Taormina, ME, Italy, 98039 | |
Novartis Investigative Site | |
Milano, MI, Italy, 20121 | |
Novartis Investigative Site | |
Milano, MI, Italy, 20132 | |
Novartis Investigative Site | |
Milano, MI, Italy, 20133 | |
Novartis Investigative Site | |
Milano, MI, Italy, 20141 | |
Novartis Investigative Site | |
Milano, MI, Italy, 20162 | |
Novartis Investigative Site | |
Rozzano, MI, Italy, 20089 | |
Novartis Investigative Site | |
Modena, MO, Italy, 41124 | |
Novartis Investigative Site | |
Nuoro, NU, Italy, 08100 | |
Novartis Investigative Site | |
Palermo, PA, Italy, 90127 | |
Novartis Investigative Site | |
Palermo, PA, Italy, 90146 | |
Novartis Investigative Site | |
Padova, PD, Italy, 35100 | |
Novartis Investigative Site | |
Pisa, PI, Italy, 56126 | |
Novartis Investigative Site | |
Aviano, PN, Italy, 33081 | |
Novartis Investigative Site | |
Prato, PO, Italy, 59100 | |
Novartis Investigative Site | |
Parma, PR, Italy, 43100 | |
Novartis Investigative Site | |
Fano, PU, Italy, 61032 | |
Novartis Investigative Site | |
Reggio Calabria, RC, Italy, 89124 | |
Novartis Investigative Site | |
Reggio Emilia, RE, Italy, 42123 | |
Novartis Investigative Site | |
Roma, RM, Italy, 00128 | |
Novartis Investigative Site | |
Roma, RM, Italy, 00152 | |
Novartis Investigative Site | |
Roma, RM, Italy, 00161 | |
Novartis Investigative Site | |
Roma, RM, Italy, 00168 | |
Novartis Investigative Site | |
Roma, RM, Italy, 00189 | |
Novartis Investigative Site | |
Salerno, SA, Italy, 84131 | |
Novartis Investigative Site | |
Siena, SI, Italy, 53100 | |
Novartis Investigative Site | |
Sassari, SS, Italy, 07100 | |
Novartis Investigative Site | |
Savona, SV, Italy, 17100 | |
Novartis Investigative Site | |
Trento, TN, Italy, 38100 | |
Novartis Investigative Site | |
Candiolo, TO, Italy, 10060 | |
Novartis Investigative Site | |
Torino, TO, Italy, 10126 | |
Novartis Investigative Site | |
Terni, TR, Italy, 05100 | |
Novartis Investigative Site | |
Udine, UD, Italy, 33100 | |
Novartis Investigative Site | |
Saronno, Va, Italy, 21047 | |
Novartis Investigative Site | |
Mirano, VE, Italy, 30035 | |
Novartis Investigative Site | |
Negrar, VR, Italy, 37024 | |
Novartis Investigative Site | |
Verona, VR, Italy, 37126 | |
Novartis Investigative Site | |
Viterbo, VT, Italy, 01100 | |
Novartis Investigative Site | |
Bologna, Italy, 40138 | |
Novartis Investigative Site | |
Napoli, Italy, 80131 | |
Novartis Investigative Site | |
Napoli, Italy, 80138 | |
Novartis Investigative Site | |
Novara, Italy, 28100 | |
Novartis Investigative Site | |
Pavia, Italy, 27100 | |
Jordan | |
Novartis Investigative Site | |
Amman, Jordan, 11941 | |
Lebanon | |
Novartis Investigative Site | |
Ashrafieh, Lebanon, 166830 | |
Novartis Investigative Site | |
Beirut, Lebanon | |
Novartis Investigative Site | |
Saida, Lebanon, 652 | |
Malaysia | |
Novartis Investigative Site | |
Tanjong Bungah, Penang, Malaysia, 11200 | |
Novartis Investigative Site | |
Petaling Jaya, Selangor, Malaysia, 46050 | |
Novartis Investigative Site | |
Kuala Lumpur, Wilayah Persekutuan, Malaysia, 50586 | |
Novartis Investigative Site | |
Putrajaya, Wilayah Persekutuan, Malaysia, 62250 | |
Novartis Investigative Site | |
Kuala Lumpur, Malaysia, 59100 | |
Mexico | |
Novartis Investigative Site | |
Monterrey, Nuevo León, Mexico, 64710 | |
Novartis Investigative Site | |
Ciudad de Mexico, Mexico, 04700 | |
Novartis Investigative Site | |
Mexico City, Mexico, 01120 | |
Netherlands | |
Novartis Investigative Site | |
Maastricht, AZ, Netherlands, 5800 | |
Novartis Investigative Site | |
Venray, CE, Netherlands, 5801 | |
Novartis Investigative Site | |
Apeldoorn, DZ, Netherlands, 7334 | |
Novartis Investigative Site | |
Arnhem, Netherlands, 6815 AD | |
Novartis Investigative Site | |
Beverwijk, Netherlands, 1942 LE | |
Novartis Investigative Site | |
Breda, Netherlands, 4818 CK | |
Novartis Investigative Site | |
Delft, Netherlands, 2625 AD | |
Novartis Investigative Site | |
Den Bosch, Netherlands, 5223 GZ | |
Novartis Investigative Site | |
Den Haag, Netherlands, 2545 CH | |
Novartis Investigative Site | |
Dordrecht, Netherlands, 3318AT | |
Novartis Investigative Site | |
Ede, Netherlands, 6716 RP | |
Novartis Investigative Site | |
Eindhoven, Netherlands, 5623EJ | |
Novartis Investigative Site | |
Enschede, Netherlands, 7513 ER | |
Novartis Investigative Site | |
Goes, Netherlands, 4462 RA | |
Novartis Investigative Site | |
Groningen, Netherlands, 9728 NZ | |
Novartis Investigative Site | |
Hilversum, Netherlands, XZ1213 | |
Novartis Investigative Site | |
Hoofddorp, Netherlands, 2134 TM | |
Novartis Investigative Site | |
Leeuwarden, Netherlands, 8934 AD | |
Novartis Investigative Site | |
Roermond, Netherlands, 6043 CV | |
Novartis Investigative Site | |
Rotterdam, Netherlands, 3079 DZ | |
Novartis Investigative Site | |
Sittard-Geleen, Netherlands, 6162 BG | |
Novartis Investigative Site | |
Utrecht, Netherlands, 3543 AZ | |
Novartis Investigative Site | |
Zutphen, Netherlands, 7207 AE | |
Novartis Investigative Site | |
Zwolle, Netherlands, 8025 AB | |
Norway | |
Novartis Investigative Site | |
Gralum, Norway, 1714 | |
Novartis Investigative Site | |
Oslo, Norway, 0379 | |
Novartis Investigative Site | |
Oslo, Norway, NO 0450 | |
Novartis Investigative Site | |
Stavanger, Norway, NO-4068 | |
Oman | |
Novartis Investigative Site | |
Muscat, Oman, 123 | |
Panama | |
Novartis Investigative Site | |
Panama City, Panama | |
Philippines | |
Novartis Investigative Site | |
Taguig City, Metro Manila, Philippines, 1634 | |
Novartis Investigative Site | |
Las Pinas, Philippines, 1740 | |
Novartis Investigative Site | |
San Juan City, Philippines, 1500 | |
Poland | |
Novartis Investigative Site | |
Zory, Slaskie, Poland, 44-240 | |
Novartis Investigative Site | |
Bydgoszcz, Poland, 85 796 | |
Novartis Investigative Site | |
Bytom, Poland, 41-902 | |
Novartis Investigative Site | |
Gdansk, Poland, 80 952 | |
Novartis Investigative Site | |
Krakow, Poland, 31-501 | |
Novartis Investigative Site | |
Lublin, Poland, 20 090 | |
Novartis Investigative Site | |
Opole, Poland, 45-061 | |
Novartis Investigative Site | |
Rzeszow, Poland, 35-021 | |
Novartis Investigative Site | |
Warszawa, Poland, 02 781 | |
Novartis Investigative Site | |
Wroclaw, Poland, 53 413 | |
Portugal | |
Novartis Investigative Site | |
Braga, Portugal, 4710243 | |
Novartis Investigative Site | |
Guimaraes, Portugal, 4835-044 | |
Novartis Investigative Site | |
Lisboa, Portugal, 1400-038 | |
Novartis Investigative Site | |
Lisboa, Portugal, 1500 650 | |
Novartis Investigative Site | |
Lisboa, Portugal, 1649-035 | |
Novartis Investigative Site | |
Lisboa, Portugal, 1998-018 | |
Novartis Investigative Site | |
Porto, Portugal, 4099-001 | |
Novartis Investigative Site | |
Porto, Portugal, 4200-072 | |
Novartis Investigative Site | |
Porto, Portugal, 4200-319 | |
Russian Federation | |
Novartis Investigative Site | |
Leningrad Region, Russia, Russian Federation, 188663 | |
Novartis Investigative Site | |
Kazan, Tatarstan Republic, Russian Federation, 420029 | |
Novartis Investigative Site | |
Chelyabinsk, Russian Federation, 454087 | |
Novartis Investigative Site | |
Irkutsk, Russian Federation, 664035 | |
Novartis Investigative Site | |
Kaluga, Russian Federation, 248007 | |
Novartis Investigative Site | |
Krasnoyarsk, Russian Federation, 660022 | |
Novartis Investigative Site | |
Moscow Rerion Balashiha, Russian Federation, 143900 | |
Novartis Investigative Site | |
Moscow, Russian Federation, 115478 | |
Novartis Investigative Site | |
Moscow, Russian Federation, 125284 | |
Novartis Investigative Site | |
Moscow, Russian Federation, 143423 | |
Novartis Investigative Site | |
Rostov-na-Donu, Russian Federation, 344037 | |
Novartis Investigative Site | |
Samara, Russian Federation, 443031 | |
Novartis Investigative Site | |
St Petersburg, Russian Federation, 197022 | |
Novartis Investigative Site | |
St Petersburg, Russian Federation, 197758 | |
Novartis Investigative Site | |
Ufa, Russian Federation, 450054 | |
Novartis Investigative Site | |
Yaroslavl, Russian Federation, 150054 | |
Saudi Arabia | |
Novartis Investigative Site | |
Dammam, Saudi Arabia, 15215 | |
Novartis Investigative Site | |
Makkah, Saudi Arabia, 57657 | |
Novartis Investigative Site | |
Riyadh, Saudi Arabia, 11211 | |
Novartis Investigative Site | |
Riyadh, Saudi Arabia, 11426 | |
Singapore | |
Novartis Investigative Site | |
Singapore, Singapore, 217562 | |
Novartis Investigative Site | |
Singapore, Singapore, 258500 | |
Novartis Investigative Site | |
Singapore, Singapore, 308433 | |
Slovakia | |
Novartis Investigative Site | |
Banska Bystrica, Slovak Republic, Slovakia, 97401 | |
Novartis Investigative Site | |
Kosice, Slovakia, 04191 | |
Novartis Investigative Site | |
Poprad, Slovakia, 058 01 | |
Slovenia | |
Novartis Investigative Site | |
Ljubljana, Slovenia, 1000 | |
Novartis Investigative Site | |
Maribor, Slovenia, 2000 | |
Spain | |
Novartis Investigative Site | |
Elche, Alicante, Spain, 03203 | |
Novartis Investigative Site | |
Almeria, Andalucia, Spain, 04009 | |
Novartis Investigative Site | |
Cordoba, Andalucia, Spain, 14004 | |
Novartis Investigative Site | |
Granada, Andalucia, Spain, 18014 | |
Novartis Investigative Site | |
Huelva, Andalucia, Spain, 21005 | |
Novartis Investigative Site | |
Jaen, Andalucia, Spain, 23007 | |
Novartis Investigative Site | |
Malaga, Andalucia, Spain, 29010 | |
Novartis Investigative Site | |
Sevilla, Andalucia, Spain, 41009 | |
Novartis Investigative Site | |
Sevilla, Andalucia, Spain, 41013 | |
Novartis Investigative Site | |
Sevilla, Andalucia, Spain, 41014 | |
Novartis Investigative Site | |
Sabadell, Barcelona, Spain, 08208 | |
Novartis Investigative Site | |
Jerez, Cadiz, Spain, 11407 | |
Novartis Investigative Site | |
Toledo, Castilla La Mancha, Spain, 45071 | |
Novartis Investigative Site | |
Salamanca, Castilla Y Leon, Spain, 37007 | |
Novartis Investigative Site | |
Lleida, Cataluna, Spain, 25198 | |
Novartis Investigative Site | |
Badalona, Catalunya, Spain, 08916 | |
Novartis Investigative Site | |
Barcelona, Catalunya, Spain, 08035 | |
Novartis Investigative Site | |
Barcelona, Catalunya, Spain, 08036 | |
Novartis Investigative Site | |
Girona, Catalunya, Spain, 17007 | |
Novartis Investigative Site | |
Hospitalet de LLobregat, Catalunya, Spain, 08907 | |
Novartis Investigative Site | |
Barcelona, Cataluña, Spain, 08024 | |
Novartis Investigative Site | |
Alicante, Comunidad Valenciana, Spain, 03010 | |
Novartis Investigative Site | |
Alicante, Comunidad Valenciana, Spain, 03550 | |
Novartis Investigative Site | |
Castellon, Comunidad Valenciana, Spain, 12002 | |
Novartis Investigative Site | |
Valencia, Comunidad Valenciana, Spain, 46009 | |
Novartis Investigative Site | |
Valencia, Comunidad Valenciana, Spain, 46010 | |
Novartis Investigative Site | |
Valencia, Comunidad Valenciana, Spain, 46014 | |
Novartis Investigative Site | |
Valencia, Comunidad Valenciana, Spain, 46015 | |
Novartis Investigative Site | |
Badajoz, Extremadura, Spain, 06080 | |
Novartis Investigative Site | |
Caceres, Extremadura, Spain, 10003 | |
Novartis Investigative Site | |
La Coruna, Galicia, Spain, 15006 | |
Novartis Investigative Site | |
Santiago de Compostela, Galicia, Spain, 15706 | |
Novartis Investigative Site | |
Palma De Mallorca, Islas Baleares, Spain, 07120 | |
Novartis Investigative Site | |
Las Palmas De Gran Canarias, Las Palmas De Gran Canaria, Spain, 35016 | |
Novartis Investigative Site | |
El Palmar, Murcia, Spain, 30120 | |
Novartis Investigative Site | |
Pamplona, Navarra, Spain, 31008 | |
Novartis Investigative Site | |
Bilbao, Pais Vasco, Spain, 48013 | |
Novartis Investigative Site | |
San Sebastian, Pais Vasco, Spain, 20080 | |
Novartis Investigative Site | |
Vigo, Pontevedra, Spain, 36212 | |
Novartis Investigative Site | |
La Laguna, Santa Cruz De Tenerife, Spain, 38320 | |
Novartis Investigative Site | |
Reus, Tarragona, Spain, 43201 | |
Novartis Investigative Site | |
Barcelona, Spain, 08041 | |
Novartis Investigative Site | |
Burgos, Spain, 09006 | |
Novartis Investigative Site | |
Granollers, Spain, 08402 | |
Novartis Investigative Site | |
Madrid, Spain, 28006 | |
Novartis Investigative Site | |
Madrid, Spain, 28009 | |
Novartis Investigative Site | |
Madrid, Spain, 28034 | |
Novartis Investigative Site | |
Madrid, Spain, 28040 | |
Novartis Investigative Site | |
Madrid, Spain, 28041 | |
Novartis Investigative Site | |
Madrid, Spain, 28046 | |
Novartis Investigative Site | |
Madrid, Spain, 28222 | |
Novartis Investigative Site | |
Murcia, Spain, 30008 | |
Novartis Investigative Site | |
Valencia, Spain, 46026 | |
Novartis Investigative Site | |
Zaragoza, Spain, 50009 | |
Sweden | |
Novartis Investigative Site | |
Gothenburg, Sweden, SE-431 45 | |
Novartis Investigative Site | |
Orebro, Sweden, 701 85 | |
Novartis Investigative Site | |
Stockholm, Sweden, SE-118 83 | |
Novartis Investigative Site | |
Uppsala, Sweden, 751 85 | |
Novartis Investigative Site | |
Vaxjo, Sweden, SE-351 85 | |
Taiwan | |
Novartis Investigative Site | |
Taichung, Taiwan, 40447 | |
Novartis Investigative Site | |
Tainan, Taiwan, 70403 | |
Novartis Investigative Site | |
Taipei, Taiwan, 114 | |
Thailand | |
Novartis Investigative Site | |
Songkhla, Hat Yai, Thailand, 90110 | |
Novartis Investigative Site | |
Khon Kaen, THA, Thailand, 40002 | |
Novartis Investigative Site | |
Bangkok, Thailand, 10400 | |
Novartis Investigative Site | |
Chiang Mai, Thailand, 50200 | |
United Kingdom | |
Novartis Investigative Site | |
Peterborough, Cambridgeshire, United Kingdom, PE3 9GZ | |
Novartis Investigative Site | |
Truro, Cornwall, United Kingdom, TR1 3LJ | |
Novartis Investigative Site | |
Portsmouth, Hants, United Kingdom, PO6 3LY | |
Novartis Investigative Site | |
Maidstone, Kent, United Kingdom, ME16 9QQ | |
Novartis Investigative Site | |
York, North Yorkshire, United Kingdom, YO31 8HE | |
Novartis Investigative Site | |
Aberdeen, Scotland, United Kingdom, AB25 2ZN | |
Novartis Investigative Site | |
Ipswich, Suffolk, United Kingdom, IP4 5PD | |
Novartis Investigative Site | |
Guildford, Surrey, United Kingdom, GU2 7XX | |
Novartis Investigative Site | |
Sutton, Surrey, United Kingdom, SM2 5PT | |
Novartis Investigative Site | |
Bristol, United Kingdom, BS2 8ED | |
Novartis Investigative Site | |
Cardiff, United Kingdom, CF14 2TL | |
Novartis Investigative Site | |
East Sussex, United Kingdom, BN2 5BE | |
Novartis Investigative Site | |
Edinburgh, United Kingdom, EH4 2XU | |
Novartis Investigative Site | |
Exeter, United Kingdom, EX2 5DW | |
Novartis Investigative Site | |
Glasgow, United Kingdom, G12 0YN | |
Novartis Investigative Site | |
Leeds, United Kingdom, LS9 7TF | |
Novartis Investigative Site | |
Leicester, United Kingdom, LE1 5WW | |
Novartis Investigative Site | |
London, United Kingdom, NW1 2PJ | |
Novartis Investigative Site | |
London, United Kingdom, SW3 6JJ | |
Novartis Investigative Site | |
London, United Kingdom, W8 6RF | |
Novartis Investigative Site | |
Manchester, United Kingdom, M20 4BX | |
Novartis Investigative Site | |
Newcastle upon Tyne, United Kingdom, NE7 7DN | |
Novartis Investigative Site | |
Nottingham, United Kingdom, NG5 1PB | |
Novartis Investigative Site | |
Oxford, United Kingdom, OX3 7LJ | |
Novartis Investigative Site | |
Plymouth, United Kingdom, PL6 8DH | |
Novartis Investigative Site | |
Preston, United Kingdom, PR2 9HT | |
Novartis Investigative Site | |
Sheffield, United Kingdom, S10 2SJ | |
Novartis Investigative Site | |
Stoke-on-Trent, United Kingdom, ST4 6QG |
Study Director: | Novartis Pharmaceuticals | Novartis Pharmaceuticals |
Responsible Party: | Novartis Pharmaceuticals |
ClinicalTrials.gov Identifier: | NCT02941926 |
Other Study ID Numbers: |
CLEE011A2404 |
First Posted: | October 21, 2016 Key Record Dates |
Last Update Posted: | October 6, 2020 |
Last Verified: | September 2020 |
Studies a U.S. FDA-regulated Drug Product: | Yes |
HR-positive HER2-negative advanced breast cancer LEE011 ribociclib letrozole goserelin CDK CDK4 |
CDK6 CDK4/6 Phase IIIb ER-positive PR-positive premenopausal postmenopausal men with advanced breast cancer |
Breast Neoplasms Neoplasms by Site Neoplasms Breast Diseases Skin Diseases Letrozole Leuprolide Goserelin Antineoplastic Agents Aromatase Inhibitors Steroid Synthesis Inhibitors |
Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Estrogen Antagonists Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs Fertility Agents, Female Fertility Agents Reproductive Control Agents Antineoplastic Agents, Hormonal |