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Trial record 10 of 14 for:    hyperbaric AND carbon AND monoxide AND poisoning

Occult Carbon Monoxide Poisoning Detection by Pulsated Carboxymetry in an Emergency Department (MAS-CO)

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ClinicalTrials.gov Identifier: NCT02931448
Recruitment Status : Unknown
Verified October 2016 by Poitiers University Hospital.
Recruitment status was:  Recruiting
First Posted : October 13, 2016
Last Update Posted : October 23, 2017
Sponsor:
Information provided by (Responsible Party):
Poitiers University Hospital

Brief Summary:

In France, the carbon monoxide is one of the first causes of the accidental poisonings with approximately 8000 cases a year, among which 500 deaths.

The severe forms are translated by neurological disorders even a coma or the death straight away. The more insidious forms with a little carboxyhémoglobine level give rise to frustrate clinical pictures, mimicking flu or intestinal syndromes. The syndrome post--intervallaire corresponds to the appearance of remote neuropsychiatric disorders of the poisoning. Its appearance and its gravity are not correlated in the gravity of the initial poisoning, however the precocity of the treatment tends to decrease its frequency.

Carbon monoxide elimination is made under unchanged form in the expired air. In a spontaneous way, the half-life in ambient air is of the order of 4 hours. In ventilation in isobaric pure oxygen, the half-life is shortened at 80 minutes and in hyperbaric oxygen at 23 minutes.

This imposes a fast diagnosis for two reasons:

  • For poisonings with low level, the more the investigators wait to measure the carboxyhémoglobine (HBCO), the more they risk not to detect it.
  • The oxygen therapy decreases the duration of the poisoning and thus the tissular suffering.

Actually the risk is important to pass next to the diagnosis and to let leave a patient without adapted care and without technical intervention to eliminate the source of the poisoning.

Presently, to make the diagnosis, the investigators possess the analysis of the blood HbCO by realization of gas of the venous blood, which are taken in emergencies, but very often a few hours after the end of the exposure at the source of poisoning, what is translated by a disappearance of the symptoms and an underestimate of the initial blood HbCO. Since 2005, MASIMO laboratory commercialize a pulse carboxymètre, the RAD 57, which allows to estimate the carboxyhémoglobinémie in a not invasive way.

Lot of studies showed the interest of its use in the early screening of carbon monoxide poisonings, allowing a faster dosage of the blood HbCO, and thus an also faster adapted care.


Condition or disease Intervention/treatment
Carbon Monoxide Poisoning Device: Dosage of the blood HbCO thanks to the carboxymeter MASIMO RAD 57

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Study Type : Observational
Estimated Enrollment : 150 participants
Observational Model: Case-Only
Time Perspective: Prospective
Actual Study Start Date : October 2016
Estimated Primary Completion Date : October 2018
Estimated Study Completion Date : October 2018

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Incidence of poisoning carbon monoxide confirmed [ Time Frame: up to 24 hours ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

The eligible patients are the ones appearing at emergencies for headaches, nausea and/or vomitings, faintness with or without loss of consciousness, dizzinesses, asthenia, and presenting all the criteria of inclusion and the absence of the criteria of not inclusion.

Considering the particularity of the foetal poisoning in the carbon monoxide, the pregnant women cannot be included in the study.

Criteria

Inclusion Criteria:

Patients over 18 years old consult in ED for :

  • cephalalgia
  • syncope
  • weakness
  • nausea
  • vomiting
  • asthenia

Exclusion Criteria:

  • temperature over 38.5 °C

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02931448


Contacts
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Contact: Jérémy Guénézan, Hospital practitioner 05.49.44.36.94 jeremy.guenezan@chu-poitiers.fr
Contact: Olivier Mimoz, Professor 05.49.44.46.00 olivier.mimoz@chu-poitiers.fr

Locations
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France
Poitiers Universitary Hospital Recruiting
Poitiers, France, 86021
Contact: Nicolas MARJANOVIC, Hospital practitioner    05.49.44.18.73    nicolas.marjanovic@chu-poitiers.fr   
Contact: Jérémy GUENEZAN, Hospital practitioner    05.49.44.36.94    jeremy.guenezan@chu-poitiers.fr   
Principal Investigator: Jérémy GUENEZAN, Hospital practitioner         
Sub-Investigator: Nicolas MARJANOVIC, Hospital practitioner         
Sub-Investigator: Erwan RIPLEY, Hospital practitioner         
Sponsors and Collaborators
Poitiers University Hospital

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Responsible Party: Poitiers University Hospital
ClinicalTrials.gov Identifier: NCT02931448     History of Changes
Other Study ID Numbers: MAS-CO
First Posted: October 13, 2016    Key Record Dates
Last Update Posted: October 23, 2017
Last Verified: October 2016
Keywords provided by Poitiers University Hospital:
Device assessment
Additional relevant MeSH terms:
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Poisoning
Carbon Monoxide Poisoning
Chemically-Induced Disorders
Gas Poisoning