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Impact Evaluation of Urban Water Supply Improvements on Cholera and Other Diarrhoeal Diseases in Uvira, Democratic Republic of Congo

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02928341
Recruitment Status : Completed
First Posted : October 10, 2016
Last Update Posted : August 26, 2022
Sponsor:
Information provided by (Responsible Party):
London School of Hygiene and Tropical Medicine

Study Description
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Brief Summary:
The aim of the study is to evaluate the impact of a large-scale urban water supply improvement intervention on cholera and other diarrhoeal diseases. The study uses a step wedge cluster randomised controlled trial (SWcRCT) to measure the effect of the intervention on cholera centre admission rates and confirmed cholera cases. A nested cohort study will examine changes in water-related practices following the intervention.

Condition or disease Intervention/treatment Phase
Cholera Diarrhea Other: Improved water supply Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 4556 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Impact Evaluation of Urban Water Supply Improvements on Cholera and Other Diarrhoeal in Uvira, Democratic Republic of Congo
Actual Study Start Date : October 2016
Actual Primary Completion Date : December 31, 2021
Actual Study Completion Date : December 31, 2021

Resource links provided by the National Library of Medicine


Arms and Interventions
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Arm Intervention/treatment
No Intervention: No intervention
Current water supply access
Experimental: Intervention
Received water supply improvement intervention designed to improve access to tap water, consisting of community managed public taps, improved tap water distribution network, refurbished tap connections and promotion of new household tap connections.
 Other: Improved water supply


Outcome Measures
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Primary Outcome Measures :
  1. Admission rate to the Uvira Cholera Treatment Centre [ Time Frame: 36 months ]

Secondary Outcome Measures :
  1. Admission rate to the Uvira Cholera Treatment Centre of laboratory confirmed cholera cases [ Time Frame: 36 months ]

Eligibility Criteria
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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Uvira resident admitted to the Uvira Cholera Treatment Centre in Uvira

Exclusion Criteria:

  • Any patients admitted during the period of intervention implementation in each cluster
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02928341


Locations
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Congo, The Democratic Republic of the
Centre de Traitement du Cholera, Hôpital General de Reference d'Uvira, Sud-Kivu, République Démocratique du Congo
Uvira, Sud-Kivu, Congo, The Democratic Republic of the
Sponsors and Collaborators
London School of Hygiene and Tropical Medicine
Investigators
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Principal Investigator: Oliver Cumming, MSc London School of Hygiene and Tropical Medicine
Principal Investigator: Karin Gallandat, PhD London School of Hygiene and Tropical Medicine
More Information
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Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: London School of Hygiene and Tropical Medicine
ClinicalTrials.gov Identifier: NCT02928341    
Other Study ID Numbers: 8913
First Posted: October 10, 2016    Key Record Dates
Last Update Posted: August 26, 2022
Last Verified: August 2022
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Additional relevant MeSH terms:
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Cholera
Diarrhea
Signs and Symptoms, Digestive
Vibrio Infections
 Gram-Negative Bacterial Infections
Bacterial Infections
Bacterial Infections and Mycoses
Infections