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Glucose Response From Antioxidant Rich Potato Chips

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ClinicalTrials.gov Identifier: NCT02927015
Recruitment Status : Completed
First Posted : October 6, 2016
Last Update Posted : October 6, 2016
Sponsor:
Collaborator:
PepsiCo Global R&D
Information provided by (Responsible Party):
Richard Mattes, Purdue University

Brief Summary:
Assess impact of potato phytochemical on post-prandial gastric emptying and glucose release from products in a pilot human study.

Condition or disease Intervention/treatment Phase
Glycemic Response Other: Purple Majesty potato chips Other: Mountain Rose potato chips Other: White potato chips Other: Crackers Not Applicable

Detailed Description:
Preclinical data obtained using an Caco-2 intestinal cell model and enzyme assays suggest phenolic-rich potato extracts decrease intestinal glucose transport. The aim is to determine if these effects extend to the the an in vivo situation. Specifically, the glycemic response following consumption of phenolic rich pigmented potatoes compared to white potatoes with lower phenolic content will be measured. Gastric emptying will also be measured to show the effects are in fact due to rate of carbohydrate digestion and intestinal glucose transport and not gastric emptying rate.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 11 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Glucose Response From Antioxidant Rich Potato Chips
Study Start Date : January 2016
Actual Primary Completion Date : February 2016
Actual Study Completion Date : June 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Antioxidants

Arm Intervention/treatment
Experimental: Purple Majesty potato chips
Purple Majesty potato chips
Other: Purple Majesty potato chips
Purple Majesty potato chips

Experimental: Mountain Rose potato chips
Mountain Rose potato chips
Other: Mountain Rose potato chips
Mountain Rose potato chips

Experimental: White potato chips
White potato chips
Other: White potato chips
White potato chips

Experimental: Crackers
Crackers
Other: Crackers
Crackers




Primary Outcome Measures :
  1. Blood Glucose [ Time Frame: up to 2 hours ]
    blood taken at 10, 20, 30, 60, and 120 minutes by finger prick

  2. Gastric emptying [ Time Frame: up to 4 hours ]
    Breath Hydrogen concentrations will be measured every 15 minutes for 4 hours



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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI 18-25 non-smoker

Exclusion Criteria:

  • BMI outside 18-25 smoker previous gastrointestinal disease or other disease

Responsible Party: Richard Mattes, Prof. Nutrition Sciences, Purdue University
ClinicalTrials.gov Identifier: NCT02927015     History of Changes
Other Study ID Numbers: 055-043
First Posted: October 6, 2016    Key Record Dates
Last Update Posted: October 6, 2016
Last Verified: October 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Additional relevant MeSH terms:
Antioxidants
Iproplatin
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs
Antineoplastic Agents