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The Investigation of the Depression in Osteoarthritis

This study is not yet open for participant recruitment.
Verified October 2016 by Wenjun Wang, Dalian Municipal Central Hospital
Sponsor:
ClinicalTrials.gov Identifier:
NCT02924662
First Posted: October 5, 2016
Last Update Posted: October 12, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by (Responsible Party):
Wenjun Wang, Dalian Municipal Central Hospital
  Purpose

Studies have reported that the patient's psychological state such as anxiety, depression and other emotion affect the therapeutic effect of osteoarthritis, also may be the important reason for the poor knee joint osteoarthritis efficacy.

The aim of this study are firstly to investigate the depression status of patients with osteoarthritis. Secondly, the study will aim to assess whether osteoarthritis progression will affect depression status, ultimately, provide reference for clinical.


Condition Intervention
Depression Other: There is no intervention.

Study Type: Observational
Study Design: Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: The Investigation of the Depression in Osteoarthritis

Resource links provided by NLM:


Further study details as provided by Wenjun Wang, Dalian Municipal Central Hospital:

Primary Outcome Measures:
  • Western Ontario and McMaster OA index (WOMAC) [ Time Frame: Day 1 ]
  • American knee society knee score [ Time Frame: Day 1 ]
  • Hamilton Depression Scale-17(HAMD-17) [ Time Frame: Day 1 ]

Estimated Enrollment: 200
Study Start Date: October 2016
Estimated Primary Completion Date: March 2017 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Kellgren and Lawrence classification I
Grade I Kellgren and Lawrence radiographic changes.
Other: There is no intervention.
Kellgren and Lawrence classification II
Grade II Kellgren and Lawrence radiographic changes.
Kellgren and Lawrence classification III
Grade III Kellgren and Lawrence radiographic changes.
Kellgren and Lawrence classification IV
Grade IV Kellgren and Lawrence radiographic changes.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The study group will be taken from a single centre. The patient population will be patients who are diagnosed with osteoarthritis. Participants will have a comprehensive and detailed assessment by a qualified doctor. After the assessment,the participants who are diagnosed with osteoarthritis and conformed to fit the eligibility criteria will be invited to join the investigation.
Criteria

Inclusion Criteria:

Meet the 1986 American College of Rheumatology (ACR) clinical criteria for knee osteoarthritis and the 2010 Chinese Medical Association clinical criteria for knee osteoarthritis.

Exclusion Criteria:

Patients with rheumatoid arthritis patients with a history of depression before osteoarthritis pathogenesis patients who can't cooperate with related inspection and assessment Patients with mental illness

  Contacts and Locations
No Contacts or Locations Provided
  More Information

Responsible Party: Wenjun Wang, MD, Dalian Municipal Central Hospital
ClinicalTrials.gov Identifier: NCT02924662     History of Changes
Other Study ID Numbers: DaLianMCH
First Submitted: October 4, 2016
First Posted: October 5, 2016
Last Update Posted: October 12, 2017
Last Verified: October 2016

Additional relevant MeSH terms:
Depression
Depressive Disorder
Osteoarthritis
Behavioral Symptoms
Mood Disorders
Mental Disorders
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases