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The Investigation of the Depression in Osteoarthritis

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified October 2016 by Dalian Municipal Central Hospital
Information provided by (Responsible Party):
Wenjun Wang, Dalian Municipal Central Hospital Identifier:
First received: October 4, 2016
Last updated: NA
Last verified: October 2016
History: No changes posted

Studies have reported that the patient's psychological state such as anxiety, depression and other emotion affect the therapeutic effect of osteoarthritis, also may be the important reason for the poor knee joint osteoarthritis efficacy.

The aim of this study are firstly to investigate the depression status of patients with osteoarthritis. Secondly, the study will aim to assess whether osteoarthritis progression will affect depression status, ultimately, provide reference for clinical.

Condition Intervention
Other: There is no intervention.

Study Type: Observational
Study Design: Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: The Investigation of the Depression in Osteoarthritis

Resource links provided by NLM:

Further study details as provided by Dalian Municipal Central Hospital:

Primary Outcome Measures:
  • Western Ontario and McMaster OA index (WOMAC) [ Time Frame: Day 1 ]
  • American knee society knee score [ Time Frame: Day 1 ]
  • Hamilton Depression Scale-17(HAMD-17) [ Time Frame: Day 1 ]

Estimated Enrollment: 200
Study Start Date: October 2016
Estimated Primary Completion Date: March 2017 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Kellgren and Lawrence classification I
Grade I Kellgren and Lawrence radiographic changes.
Other: There is no intervention.
Kellgren and Lawrence classification II
Grade II Kellgren and Lawrence radiographic changes.
Kellgren and Lawrence classification III
Grade III Kellgren and Lawrence radiographic changes.
Kellgren and Lawrence classification IV
Grade IV Kellgren and Lawrence radiographic changes.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The study group will be taken from a single centre. The patient population will be patients who are diagnosed with osteoarthritis. Participants will have a comprehensive and detailed assessment by a qualified doctor. After the assessment,the participants who are diagnosed with osteoarthritis and conformed to fit the eligibility criteria will be invited to join the investigation.

Inclusion Criteria:

Meet the 1986 American College of Rheumatology (ACR) clinical criteria for knee osteoarthritis and the 2010 Chinese Medical Association clinical criteria for knee osteoarthritis.

Exclusion Criteria:

Patients with rheumatoid arthritis patients with a history of depression before osteoarthritis pathogenesis patients who can't cooperate with related inspection and assessment Patients with mental illness

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

Responsible Party: Wenjun Wang, MD, Dalian Municipal Central Hospital Identifier: NCT02924662     History of Changes
Other Study ID Numbers: DaLianMCH
Study First Received: October 4, 2016
Last Updated: October 4, 2016

Additional relevant MeSH terms:
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases processed this record on May 24, 2017