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The Investigation of the Depression in Osteoarthritis

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ClinicalTrials.gov Identifier: NCT02924662
Recruitment Status : Not yet recruiting
First Posted : October 5, 2016
Last Update Posted : October 5, 2016
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:

Studies have reported that the patient's psychological state such as anxiety, depression and other emotion affect the therapeutic effect of osteoarthritis, also may be the important reason for the poor knee joint osteoarthritis efficacy.

The aim of this study are firstly to investigate the depression status of patients with osteoarthritis. Secondly, the study will aim to assess whether osteoarthritis progression will affect depression status, ultimately, provide reference for clinical.


Condition or disease Intervention/treatment
Depression Other: There is no intervention.

Study Design

Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: The Investigation of the Depression in Osteoarthritis
Study Start Date : October 2016
Estimated Primary Completion Date : March 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Osteoarthritis
U.S. FDA Resources

Groups and Cohorts

Group/Cohort Intervention/treatment
Kellgren and Lawrence classification I
Grade I Kellgren and Lawrence radiographic changes.
Other: There is no intervention.
Kellgren and Lawrence classification II
Grade II Kellgren and Lawrence radiographic changes.
Kellgren and Lawrence classification III
Grade III Kellgren and Lawrence radiographic changes.
Kellgren and Lawrence classification IV
Grade IV Kellgren and Lawrence radiographic changes.


Outcome Measures

Primary Outcome Measures :
  1. Western Ontario and McMaster OA index (WOMAC) [ Time Frame: Day 1 ]
  2. American knee society knee score [ Time Frame: Day 1 ]
  3. Hamilton Depression Scale-17(HAMD-17) [ Time Frame: Day 1 ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The study group will be taken from a single centre. The patient population will be patients who are diagnosed with osteoarthritis. Participants will have a comprehensive and detailed assessment by a qualified doctor. After the assessment,the participants who are diagnosed with osteoarthritis and conformed to fit the eligibility criteria will be invited to join the investigation.
Criteria

Inclusion Criteria:

Meet the 1986 American College of Rheumatology (ACR) clinical criteria for knee osteoarthritis and the 2010 Chinese Medical Association clinical criteria for knee osteoarthritis.

Exclusion Criteria:

Patients with rheumatoid arthritis patients with a history of depression before osteoarthritis pathogenesis patients who can't cooperate with related inspection and assessment Patients with mental illness

More Information

Responsible Party: Wenjun Wang, MD, Dalian Municipal Central Hospital
ClinicalTrials.gov Identifier: NCT02924662     History of Changes
Other Study ID Numbers: DaLianMCH
First Posted: October 5, 2016    Key Record Dates
Last Update Posted: October 5, 2016
Last Verified: October 2016

Additional relevant MeSH terms:
Depression
Depressive Disorder
Osteoarthritis
Behavioral Symptoms
Mood Disorders
Mental Disorders
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases