The Clinical Application of Adipose-Derived Stem Cells on Facial Rejuvenation (ADSCs)
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ClinicalTrials.gov Identifier: NCT02923219 |
Recruitment Status : Unknown
Verified October 2016 by Jin Peisheng, Xuzhou Medical University.
Recruitment status was: Not yet recruiting
First Posted : October 4, 2016
Last Update Posted : October 4, 2016
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Condition or disease | Intervention/treatment | Phase |
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Facies | Biological: Adipose-derived stem cells | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 50 participants |
Allocation: | N/A |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | The Clinical Application of Adipose-Derived Stem Cells on Facial Rejuvenation |
Study Start Date : | January 2017 |
Estimated Primary Completion Date : | January 2020 |
Estimated Study Completion Date : | January 2020 |
Arm | Intervention/treatment |
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Experimental: Stem cells separation
Stem cells separation: The adipose-derived stem cells are separated from vacuumed fat obtained through liposuction of abdomen, hip, thigh and so on. It was confirmed the adipose-derived stem cells can be induced differentiation into fat cells under the special condition in the current literature.Stem cells are used to treat wrinkles and facial rejuvenation.
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Biological: Adipose-derived stem cells
The adipose-derived stem cells therapy involve injection of patient's own adipose-derived stem cells. Local anesthetic will be applied to the face prior to the injection. For adipose-derived stem cells preparation, proper volume of fat cells will be collected from each patient just before each procedure. The stem cells will be injected into each standardized injection point in a superficial manner. The injections points are along the inferior border of cheek and mid-cheek and temple, where will be followed by 10-15 minutes of icing. |
- The therapeutic evaluation of adipose-derived stem cells or fat cells solely on facial rejuvenation [ Time Frame: 1,3 and 6 Months Post-Surgery ]With the therapeutic evaluation of adipose-derived stem cells and fat cells solely on facial rejuvenation separately, which can reduce wrinkle and augment collagen of face skin. In order to assess the therapeutic effect, the investigators take face photos/make three-dimensional skin CT of face to evaluate the wrinkle and collagen before the therapy. Then take photos of face/ make three-dimensional skin CT of face to evaluate the wrinkle and collagen/ take patient satisfaction questionnaire and clinician assessment in 1 Months post-surgery. Take photos of face/ make three-dimensional skin CT of face/ take patient satisfaction questionnaire and clinician assessment in 3 Months post-surgery. Then take photos of face/ make three-dimensional skin CT of face to evaluate the wrinkle and collagen/ take patient satisfaction questionnaire and clinician assessment in 6 Months post-surgery. The investigators will summarize the therapeutic effect of facial rejuvenation based on the data.
- The therapeutic evaluation of adipose-derived stem cells combined with fat cells on facial rejuvenation [ Time Frame: 1,3 and 6 Months Post-Surgery ]With the therapeutic evaluation of adipose-derived stem cells combined with fat cells on facial rejuvenation.The investigators take photos of face before the therapy and in 1, 3 and 6 Months Post-Surgery, take three-dimensional skin CT of face to evaluate the wrinkle and collagen and so on at the time points of pre-surgery and in 1, 3 and 6 Months post-surgery. In addition to the therapeutic evaluation, take patient satisfaction questionnaire and clinician assessment in 1, 3 and 6 Months post-surgery. The multiple measurements will be aggregated to arrive at facial rejuvenation. Compare the secondary outcome with primary outcome, then it can summarize the best method of facial rejuvenation.

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Ages Eligible for Study: | 18 Years to 60 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Males and females
- Ages18-60
- Patients of all racial and ethnic origins
- Patients of all undergoing facial rejuvenation
Exclusion Criteria:
- Ages under 18, and above 60
- Female patients in pregnancy or menstrual period
- Patients undergoing facial rejuvenation using other methods including botox injections, chemical peels, face lifts and others
- Patients using blood thinners, aspirin and hormone, that cannot be stopped
- Patients suffering with severe organic disease, such as coronary heart disease, hypertension, diabetes, lung dysfunction and so on
- Patients suffering with mental disease, and acute or chronic infectious diseases

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02923219
Contact: Jin Peisheng | +860516-85802212 | jinps2006@163.com |
Principal Investigator: | Jin Peisheng | the Affiliated Hospital of the XuZhou Medical University |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Jin Peisheng, Vice-President of the Affiliated Hospital of Xuzhou Medical College, Xuzhou Medical University |
ClinicalTrials.gov Identifier: | NCT02923219 |
Other Study ID Numbers: |
XYFY2016-KL020-01 |
First Posted: | October 4, 2016 Key Record Dates |
Last Update Posted: | October 4, 2016 |
Last Verified: | October 2016 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | Undecided |
Facial Rejuvenation Adipose-Derived Stem Cells |
Facies Disease Attributes Pathologic Processes |