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The Effect of an Acute Bout of Exercise on High-sugar Meal Induced Endothelial Dysfunction

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ClinicalTrials.gov Identifier: NCT02919488
Recruitment Status : Completed
First Posted : September 29, 2016
Last Update Posted : April 27, 2018
Sponsor:
Information provided by (Responsible Party):
Meena Shah, Texas Christian University

Brief Summary:
The purpose of this study is to determine if postprandial (after a meal) endothelial (inner lining of blood vessels) dysfunction induced by a high sugar meal improves with a bout of exercise

Condition or disease Intervention/treatment Phase
Endothelial Dysfunction Other: Exercise Condition Other: Control Condition Not Applicable

Detailed Description:

Endothelial dysfunction is due to an imbalance between vasodilating and vasoconstricting substances produced by the endothelium. An imbalance in these substances limits the ability of the blood vessel to relax in response to a shear stress stimulus. Endothelial dysfunction is a major risk factor for cardiovascular disease.

High-sugar intakes result in postprandial hyperglycemia and endothelial dysfunction. Exercise may attenuate the endothelial dysfunction induced by a high-sugar meal. There are only two studies that have examined the effect of exercise on endothelial dysfunction induced by high-sugar intake. Both studies found that a bout of aerobic exercise attenuated the impaired flow mediated dilation induced by high-sugar ingestion. Neither study measured important markers of endothelial dysfunction such as blood nitric oxide, endothelin I, and angiotensin II concentrations, however. In addition, whether the same results apply to older post-menopausal women is unknown. Understanding how acute exercise affects meal-induced endothelial dysfunction in older women is important given that age is related to endothelial dysfunction and cardiovascular disease.


Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 22 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: The Effect of an Acute Bout of Exercise on High-sugar Meal Induced Endothelial Dysfunction
Study Start Date : November 2016
Actual Primary Completion Date : December 2017
Actual Study Completion Date : December 2017

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Exercise Condition Other: Exercise Condition
A bout of exercise in the evening followed by high-sugar meal consumption the following morning

Active Comparator: Control Condition Other: Control Condition
Rest in the evening followed by high-sugar meal consumption the following morning




Primary Outcome Measures :
  1. Change in brachial artery flow mediated dilation [ Time Frame: 0, 60, 120, and 180 minutes ]

Secondary Outcome Measures :
  1. Change in blood nitric oxide concentration [ Time Frame: 0, 60, 120, and 180 minutes ]
  2. Change in blood endothelin-1concentration [ Time Frame: 0, 60, 120, and 180 minutes ]
  3. Change in blood angiotensin II concentration [ Time Frame: 0, 60, 120, and 180 minutes ]
  4. Change in blood glucose concentration [ Time Frame: 0, 60, 120, and 180 minutes ]
  5. Change in blood insulin concentration [ Time Frame: 0, 60, 120, and 180 minutes ]
  6. Change in blood lipoprotein particle numbers [ Time Frame: 0, 60, 120, and 180 minutes ]
  7. Change in blood lipid concentration [ Time Frame: 0, 60, 120, and 180 minutes ]


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Ages Eligible for Study:   45 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Post-menopausal women
  • Must be 45-70 years

Exclusion Criteria:

  • Use of medications or supplements to lose weight
  • Following a weight loss diet
  • Smoking
  • Heavy alcohol consumption
  • Diabetes
  • Heart disease
  • Stroke
  • Liver disease
  • Kidney disease
  • Untreated thyroid disease
  • Anemia
  • Uncontrolled hypertension
  • Pulmonary disease that prevents exercise
  • Orthopedic problems that prevents exercise
  • Arthritis problems that prevent exercise
  • Musculoskeletal problems that prevent exercise.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02919488


Locations
United States, Texas
Texas Christian University
Fort Worth, Texas, United States, 76129
Sponsors and Collaborators
Texas Christian University
Investigators
Principal Investigator: Meena Shah, Ph.D. Tzu Chi University

Publications:
Responsible Party: Meena Shah, Professor, Texas Christian University
ClinicalTrials.gov Identifier: NCT02919488     History of Changes
Other Study ID Numbers: CT2016MS2
First Posted: September 29, 2016    Key Record Dates
Last Update Posted: April 27, 2018
Last Verified: April 2018