TMS for Symptom Reduction in Schizophrenia
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|ClinicalTrials.gov Identifier: NCT02916810|
Recruitment Status : Recruiting
First Posted : September 27, 2016
Last Update Posted : October 7, 2019
|Condition or disease||Intervention/treatment||Phase|
|Schizophrenia and Related Disorders||Device: Active rTMS stimulation Device: Sham rTMS stimulation||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||130 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Outcomes Assessor)|
|Official Title:||TMS for Symptom Reduction in Schizophrenia|
|Actual Study Start Date :||October 2016|
|Estimated Primary Completion Date :||July 2021|
|Estimated Study Completion Date :||July 2021|
Active Comparator: Active rTMS stimulation
Real active rTMS stimulation.
Device: Active rTMS stimulation
Multiple trains of active transcranial magnetic stimulation in a day, for multiple days.
Sham Comparator: Sham rTMS stimulation
Sham repetitive TMS stimulation.
Device: Sham rTMS stimulation
Multiple trains of sham transcranial magnetic stimulation in a day, for multiple days.
- Clinician's Questionnaire for Auditory Hallucinations (CQAH) is used to evaluate the treatment effect of rTMS on auditory hallucination in schizophrenia. [ Time Frame: 4 weeks ]The study will test whether the rTMS stimulations reduce auditory hallucination of schizophrenia after the last rTMS treatment session. The CQAH will be used by an clinician to evaluate the auditory hallucination severity of schizophrenia patients before and after the rTMS series.
- Electroencephalogram (EEG) is used to evaluate the brain electrical activities that are corresponding to the treatment effect on auditory hallucination. [ Time Frame: 4 weeks ]The EEG recordings will be done before and after the rTMS series.
- Functional magnetic resonance imaging (fMRI) is used to evaluate the brain activities that are corresponding to the treatment effect on auditory hallucination. [ Time Frame: 4 weeks ]The fMRI scans will be done before and after the rTMS series.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02916810
|Contact: Xiaoming Du, PhDemail@example.com|
|Contact: Dawn Detamorefirstname.lastname@example.org|
|United States, Maryland|
|University of Maryland, Baltimore||Recruiting|
|Baltimore, Maryland, United States, 21228|
|Contact: Xiaoming Du, PhD 410-402-6036 email@example.com|
|Contact: Dawn Detamore 410-402-6820 firstname.lastname@example.org|
|Principal Investigator:||L E Hong, MD||University of Maryland, Baltimore|