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Prevalence of Malaria Parasites in People Working in Illegal Gold Mining in French Guiana (ORPAL)

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ClinicalTrials.gov Identifier: NCT02903706
Recruitment Status : Completed
First Posted : September 16, 2016
Last Update Posted : September 16, 2016
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier de Cayenne

Brief Summary:

Malaria is the most widespread parasitic illness in the world, and it is endemic to Guiana. Although the number of cases has decreased since 2005, sources of infection still remain, particularly within illegal gold mines. These malaria carriers/sufferers often use self-medication to deal with malaria symptoms, resulting in a risk of resistance to anti-malarial treatments, and particularly to artemisinine. The mobility of this population across the Guiana Shield increases both the risk of malaria spreading and the resistance of this illness to treatment in the region, and puts the population at risk of new outbreaks of this disease despite the great efforts put into anti-malarial policy in this region.

Fighting malaria within this population is therefore a dual public health challenge: on the one hand, make it possible for the WHO to eliminate malaria from the Guiana Shield by 2017, on the other to limit resistance to artemisinine in this region. However, Guiana's particular context - namely the illegal status of gold mines and the difficult geographical access, the Harpie military operations, the illegality of carrying out malarial diagnosis tests and treating cases without the presence of a health professional - prevents us from achieving this goal using the same tools as our neighbours in Suriname, whose " Looking for Gold, Finding Malaria " programme was a success.

A better understanding of the malarial epidemiology in this population will enable us to propose innovative, more adapted measures to combat malaria within these guyanese populations. This is an transversal, multicentric observational study.


Condition or disease Intervention/treatment
Malaria Epidemiology Other: Measure of Plasmodium prevalence (PCR)

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Study Type : Observational
Actual Enrollment : 421 participants
Observational Model: Case-Crossover
Time Perspective: Cross-Sectional
Official Title: Prevalence of Malaria Parasites in People Working in Illegal Gold Mining in French Guiana
Study Start Date : October 2014
Actual Primary Completion Date : June 2015
Actual Study Completion Date : June 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Malaria




Primary Outcome Measures :
  1. prevalence of malaria positive individuals (symptomatic or not symptomatic) [ Time Frame: 1 month ]
    every participant gives a capillary blood specimen which is then screened for malaria using PCR in order to obtain a prevalence of malaria positive individuals (symptomatic or not symptomatic)


Secondary Outcome Measures :
  1. Microscopy: thick and thin smear [ Time Frame: 1 month ]
    Each participant is screen for malaria using classic microscopy on thin and thick smears in order to obtain a prevalence of malaria positive individuals and to evaluate parasite quantities, and gametocyte carriage (transmission potential). If either thin or thick smears are positive then the patient is estimated to have smear positive malaria.


Biospecimen Retention:   Samples Without DNA
blood sample (5 ml) for Plasmodium PCR


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
People working on illegal gold mining sites in French Guiana.
Criteria

Inclusion Criteria:

  • works on a gold mining site in French Guiana
  • has been at the resting site for less than seven days
  • is over the age of 18
  • accepts to take part in this study

Exclusion Criteria:

  • refuses to take part in the study
  • is under the age of 18
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Centre Hospitalier de Cayenne
ClinicalTrials.gov Identifier: NCT02903706    
Other Study ID Numbers: ORPAL
First Posted: September 16, 2016    Key Record Dates
Last Update Posted: September 16, 2016
Last Verified: September 2016
Keywords provided by Centre Hospitalier de Cayenne:
gold miners
plasmodium carriers
artemisinine resistance
Additional relevant MeSH terms:
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Malaria
Protozoan Infections
Parasitic Diseases