Effect of Consumption of Non Caloric Sweeteners and Insulin Sensibility
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|ClinicalTrials.gov Identifier: NCT02890108|
Recruitment Status : Unknown
Verified August 2016 by Romina Goza Ferreira, Instituto de Nutrición y Tecnología de los Alimentos.
Recruitment status was: Recruiting
First Posted : September 7, 2016
Last Update Posted : September 7, 2016
|Condition or disease||Intervention/treatment||Phase|
|Insulin Sensitivity||Dietary Supplement: Sugar sweetened beverages Dietary Supplement: Artificially sweetened beverages||Not Applicable|
During the last decades there has been a sustained increase in prevalence of overweight and obesity and, along with it, of chronic noncommunicable diseases. There have been addressed various management strategies, including sugar replacement for Non-caloric Artificial Sweeteners (NAS). Nevertheless, in several cohort studies it has found the opposite effect, it has observed associations between the consumption of NAS with greater weight gain and increased risk of type 2 diabetes and metabolic syndrome. In clinical trials, in both humans and mice, there has been greater association with glucose intolerance, being 3 possible mechanisms: 1) dysbiosis of the intestinal microbiota; 2) altered regulation of appetite cephalic phase and secretion of glucagon like peptide-1 (GLP-1); and 3) increased intestinal glucose absorption via increased Sodium-Glucose Linked Transporter-1 (SGLT-1) and Glucose transporter 2 (GLUT2), transporters to glucose absorption.
In the following review the major findings in the literature regarding the consumption of NAS and its deleterious effects on human health will be studied.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||10 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Effect of Consumption of Non Caloric Sweeteners and Insulin Sensibility|
|Study Start Date :||August 2016|
|Estimated Primary Completion Date :||September 2016|
|Estimated Study Completion Date :||October 2016|
Experimental: Sugar sweetened beverages
Subjects will receive, in 3 different ocassions, 350cc (1 can) of a sugar sweetened beverage, that contain 38,7 grams of carbs and 154 kcal, separated by at least 1 week each one
Dietary Supplement: Sugar sweetened beverages
350 cc (1 can) of sugar sweetened beverage
Other Name: Sugar sweetened drinks
Experimental: Artificially sweetened beverage
Subjects will receive, in 3 different ocassions, 350cc (1 can) of a artificially sweetened beverage, that contain 84 mg of Aspartame, 56 mg of Acesulfame K and 0,7 kcal, separated by at least 1 week each one
Dietary Supplement: Artificially sweetened beverages
350 cc (1 can) of artificially sweetened beverage
Other Name: Artificially sweetened drinks
- Insulin sensibility [ Time Frame: Measured at 6 intervals (3 times sugar sweetened beverages and 3 times artificially sweetened beverages), separated at least by 1 week from each other. All the tests must be assessed during 10 weeks utmost. ]One insulinemic curve will be conducted to assess the effect of consumption of artificially sweetened beverage on insulin response compared to the consumption of a sugar sweetened drink.
- Glycemic response [ Time Frame: Measured at 6 intervals (3 times sugar sweetened beverages and 3 times artificially sweetened beverages), separated at least by 1 week from each other. All the tests must be assessed during 10 weeks utmost. ]One glycemic curve will be conducted to assess the effect of consumption of artificially sweetened beverage on glycemic response compared to the consumption of a sugar sweetened drink.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02890108
|Contact: Romina A Goza Ferreira, Magister email@example.com|
|Contact: Sandra Hirsch Birn, Magister||+56229781495 ext +firstname.lastname@example.org|
|Institute of Nutrition and Tecnology of Food, University of Chile||Recruiting|
|Santiago, Metropolitan region, Chile|
|Contact: Verónica Cornejo Espinoza, Director +56229781 410 email@example.com|
|Contact: Sandra Hirsch Birn, Academic +56229781495 ext +56229781499 firstname.lastname@example.org|
|Principal Investigator: Romina A Goza Ferreira, Magister c|
|Principal Investigator: Sandra Hirsch Birn, Magister|
|Sub-Investigator: Gladys Barrera Acevedo, Magister|
|Principal Investigator:||Romina A Goza Ferreira, Magister c||Institute of Nutrition and Tecnology of Food, University of Chile|
|Study Director:||Sandra Hirsch Birn, Magister||Institute of Nutrition and Tecnology of Food, University of Chile|