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Neural and Cognitive Mechanisms of Depression and Anxiety: a Multimodal MRI Study

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ClinicalTrials.gov Identifier: NCT02888509
Recruitment Status : Unknown
Verified August 2016 by chenhuafu, University of Electronic Science and Technology of China.
Recruitment status was:  Recruiting
First Posted : September 5, 2016
Last Update Posted : September 5, 2016
Sponsor:
Information provided by (Responsible Party):
chenhuafu, University of Electronic Science and Technology of China

Brief Summary:
To explore the neural and cognitive mechanisms of depression (including unipolar depression and Bipolar disorder) and anxiety using multimodal MRI techniques.

Condition or disease
Depression

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Study Type : Observational
Estimated Enrollment : 150 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Neural and Cognitive Mechanisms of Depression and Anxiety: a Multimodal MRI Study
Study Start Date : June 2015
Estimated Primary Completion Date : January 2017
Estimated Study Completion Date : January 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Anxiety

Group/Cohort
healthy control
Well mathed with patients in age, gender, education
major depression disorder
patients with major depression disorder
anxiety disorder
patients with anxiety disorder
bipolar depression disorder
patients with bilopar depression disorder



Primary Outcome Measures :
  1. Brain structural and functional changes in patients [ Time Frame: one time point ]
    Structure and function changes in patients will be assessed by Voxel-based morphometry analysis for structural changes, as well as Regional homogeneity, Amplitude of lowfrequency fluctuation, etc, for functional changes.



Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 55 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with major depression, bilopar, anxiety disorders were recruited from the mental health center of Chengdu, Sichuan, China.
Criteria

Inclusion Criteria:

  • Age range from 16 to 55 years old.
  • All patients were interviewed by two experienced psychiatrists using the Structured Clinical Interview for DSM-IV (patient edition)

Exclusion Criteria:

  • Schizophrenia, mental retardation or personality disorder, any history of loss of consciousness, substance abuse, serious medical or neurological illness.
  • Subjects with contraindications to MRI

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02888509


Contacts
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Contact: Huafu Chen chenhf@uestc.edu.cn

Locations
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China, Sichuan
School of Life Science and Technology, University of Electronic Science and Technology Recruiting
Chengdu, Sichuan, China, 610054
Contact: Huafu Chen       chenhf@uestc.edu.cn   
Sponsors and Collaborators
University of Electronic Science and Technology of China

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: chenhuafu, professor, University of Electronic Science and Technology of China
ClinicalTrials.gov Identifier: NCT02888509     History of Changes
Other Study ID Numbers: UESTC-chenhuafulab-002
First Posted: September 5, 2016    Key Record Dates
Last Update Posted: September 5, 2016
Last Verified: August 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Keywords provided by chenhuafu, University of Electronic Science and Technology of China:
depression
anxiety disorder
bipolar disorder
Magnetic Resonance Imaging

Additional relevant MeSH terms:
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Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders