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Limbal Stem Cell Deficiency of Genetic Origin: Genotype-phenotype Correlation (SILOG)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02886611
Recruitment Status : Recruiting
First Posted : September 1, 2016
Last Update Posted : December 20, 2021
Sponsor:
Information provided by (Responsible Party):
Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary:
The study aims at searching for a genotype-phenotype correlation in patients with a genetic pathology of the ocular surface, in order to identify genetic abnormalities associated with the most severe clinical situations.

Condition or disease
Limbus Corneae

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Other
Time Perspective: Cross-Sectional
Actual Study Start Date : December 15, 2015
Estimated Primary Completion Date : December 2022
Estimated Study Completion Date : December 2022



Primary Outcome Measures :
  1. Genotype-phenotype Correlation [ Time Frame: baseline ]


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with decreased visual acuity of corneal origin will be selected and genetic analysis will be performed.
Criteria

Inclusion Criteria:

  • genetic pathology of ocular surface

Exclusion Criteria:

  • Agonal glaucoma
  • Low vision mostly related to retinal pathology
  • Pregnant or breast feeding patient

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02886611


Contacts
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Contact: Laurence SALOMON, MD, PhD 0033148036431 lsalomon@for.paris

Locations
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France
Fondation Ophtalmologique Adolphe de Rothschild Recruiting
Paris, France, 75019
Contact: Eric GABISON, Pr         
Sponsors and Collaborators
Fondation Ophtalmologique Adolphe de Rothschild
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Responsible Party: Fondation Ophtalmologique Adolphe de Rothschild
ClinicalTrials.gov Identifier: NCT02886611    
Other Study ID Numbers: EGN_2015_36
First Posted: September 1, 2016    Key Record Dates
Last Update Posted: December 20, 2021
Last Verified: December 2021