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Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis

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ClinicalTrials.gov Identifier: NCT02879084
Recruitment Status : Unknown
Verified August 2016 by CHU de Quebec-Universite Laval.
Recruitment status was:  Not yet recruiting
First Posted : August 25, 2016
Last Update Posted : August 25, 2016
Sponsor:
Information provided by (Responsible Party):
CHU de Quebec-Universite Laval

Brief Summary:
This study investigates the variations in the retinal nerve fiber layer (RNFL) thickness during uncomplicated anterior and intermediate uveitis, respectively. The objectives are to 1 ) confirm the RNFL thickening during an uncomplicated anterior uveitis as described in the literature, 2) measure the RNFL thickness during an uncomplicated intermediate uveitis specifically and 3) describe the variation in time of RNFL thickness during the two types of uveitis.

Condition or disease
Anterior Uveitis Intermediate Uveitis

Detailed Description:
Thirty six individuals (18 with anterior uveitis and 18 with intermediate uveitis) will be recruited at the Centre universitaire d'ophtalmologie du CHU de Québec. RNFL thickness will be measured with optical coherence tomography at 3 times. For anterior uveitis, the RNFL thickness will be measured at presentation, 1 week and 4 to 6 weeks. For intermediate uveitis, the RNFL thickness will be measured at presentation, 4 to 6 weeks and 4 months. The initial thickness will be studied for each type of uveitis and progression over time will be studied also for each type of uveitis.

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Study Type : Observational
Estimated Enrollment : 36 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis
Study Start Date : September 2016
Estimated Primary Completion Date : January 2018
Estimated Study Completion Date : March 2018





Primary Outcome Measures :
  1. Retinal Nerve Fiber Layer Thickness in anterior uveitis [ Time Frame: At time 0 ]
  2. Retinal Nerve Fiber Layer Thickness in intermediate uveitis [ Time Frame: At time 0 ]
  3. Change from Baseline Retinal Nerve Fiber Layer Thickness in anterior uveitis [ Time Frame: at 4 to 6 weeks ]
  4. Change from Baseline Retinal Nerve Fiber Layer Thickness in intermediate uveitis [ Time Frame: at 4 months ]


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Adult of 18 years old or more with anterior or intermediate uncomplicated uveitis
Criteria

Inclusion Criteria:

  • 18 years old or more
  • anterior uncomplicated uveitis or intermediate uncomplicated uveitis

Exclusion Criteria:

  • history of uveitis in the past, other than the actual uveitis
  • history of ophthalmologic pathology with potential impact on retinal nerve fiber layer thickness
  • optic nerve or macular clinically apparent edema
  • history of glaucoma or other optic neuropathy
  • suspected or confirmed multiple sclerosis
  • ocular hypertension (intraocular pressure more than 22 mmHg)
  • reduced optical coherence tomography signal (lower than 7) on the Cirrus HD-OCT

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02879084


Contacts
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Contact: Simon Couture, Doctor Simcout@hotmail.com
Contact: Élianne De Larochellière, Doctor elianne.de-larochelliere.1@ulaval.ca

Locations
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Canada, Quebec
Centre universitaire d'ophtalmologie, Hôpital du Saint-Sacrement. CHU de Québec
Québec, Quebec, Canada, G1S 4LB
Sponsors and Collaborators
CHU de Quebec-Universite Laval
Investigators
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Principal Investigator: Simon Couture, Doctor Centre de recherche du CHU de Québec : Université Laval

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Responsible Party: CHU de Quebec-Universite Laval
ClinicalTrials.gov Identifier: NCT02879084     History of Changes
Other Study ID Numbers: 2017-3170
First Posted: August 25, 2016    Key Record Dates
Last Update Posted: August 25, 2016
Last Verified: August 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Additional relevant MeSH terms:
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Uveitis
Uveitis, Anterior
Iridocyclitis
Uveitis, Intermediate
Pars Planitis
Uveal Diseases
Eye Diseases
Panuveitis
Iris Diseases
Choroiditis
Choroid Diseases
Uveitis, Posterior