King's Invasive Aspergillosis Study II
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|ClinicalTrials.gov Identifier: NCT02875743|
Recruitment Status : Active, not recruiting
First Posted : August 23, 2016
Last Update Posted : January 25, 2019
Invasive fungal disease (IFD) is an important cause of mortality and morbidity in patients undergoing intensive chemotherapy or transplantation.
This current study aims to assess the impact of prophylactically using the broad-spectrum anti-fungal agent posaconazole on the incidence of IFD in high risk patients with aplastic anaemia and those undergoing intensive chemotherapy, for example for acute myeloid leukaemia, and allogeneic stem cell transplantation.
|Condition or disease||Intervention/treatment||Phase|
|Aplastic Anemia Leukemia, Myeloid, Acute Myelodysplastic Syndromes Bone Marrow Transplantation||Drug: Posaconazole||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||120 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Incidence of Invasive Fungal Disease in Patients Receiving Immunosuppressive Therapy, Intensive Chemotherapy or Reduced Intensity Haematopoietic Stem Cell Transplantation on Posaconazole Prophylaxis|
|Actual Study Start Date :||December 7, 2016|
|Actual Primary Completion Date :||October 31, 2018|
|Estimated Study Completion Date :||October 31, 2019|
- Cumulative incidence of IFD in all treatment groups (aplastic anaemia with IST, chemotherapy only, RIC allograft) [ Time Frame: 24 weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02875743
|King's College Hospital NHS Foundation Trust|
|London, United Kingdom, SE5 9RS|