Comparison of Th1 Cytokine Levels Between Type 1 and Type 2 Diabetes
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|ClinicalTrials.gov Identifier: NCT02860611|
Recruitment Status : Completed
First Posted : August 9, 2016
Last Update Posted : August 9, 2016
Recent reports show increased prevalence of obesity in patients with type 1 diabetes (T1DP)s while some studies stated that patients with type 2 diabetes (T2DPs) have islet cell auto-antibodies. These results raise the question of a common pathway in T1DM and T2DM via an association with T helper cells. In this study investigators aimed to investigate the difference between T helper 1 (Th1) cytokines levels in T1DPs, T2DPs and healthy subjects.
The study included 114 T1DPs on insulin treatment, 35 newly diagnosed T2DPs who had not used oral antidiabetics but insulin before and 31 healthy subjects (CG).
Serum interferon gamma (IFN-γ), interleukin-2 (IL-2) and tumor necrosis factor alpha (TNF-α) levels were measured using ELISA method. Serum levels of those cytokines in T1DPs were compared with those in T2DPs and controls.
|Condition or disease|
|Type 1 Diabetes Type 2 Diabetes|
|Study Type :||Observational|
|Actual Enrollment :||180 participants|
|Observational Model:||Case Control|
|Official Title:||Comparison of Th1 Cytokine Levels Between Type 1 and Type 2 Diabetes|
|Study Start Date :||February 2013|
|Primary Completion Date :||April 2016|
|Study Completion Date :||June 2016|
Type 1 Diabetes
Patients with type 1 diabetes
Type 2 Diabetes
Patients with type 2 diabetes
- Difference in T helper cytokines between groups [ Time Frame: 6 months ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02860611
|Medeniyet University Goztepe Training and Research Hospital|
|Istanbul, Turkey, 34730|
|Principal Investigator:||Gonca Tamer||Istanbul Medeniyet University|