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Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AK002 in Healthy Participants

This study is currently recruiting participants. (see Contacts and Locations)
Verified December 2016 by Allakos, Inc.
Sponsor:
Information provided by (Responsible Party):
Allakos, Inc.
ClinicalTrials.gov Identifier:
NCT02859701
First received: July 13, 2016
Last updated: January 18, 2017
Last verified: December 2016
  Purpose
Single-centre, randomised, double blind, placebo controlled, single ascending dose study. The study will comprise of 2 parts: Part A (Cohorts 1 and 2); Part B (Cohorts 3 to 8).

Condition Intervention Phase
Healthy
Drug: AK002
Other: Placebo
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Participant, Investigator
Primary Purpose: Treatment
Official Title: A Phase 1, Double-Blind, Placebo-Controlled, Single Ascending and Multi Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AK002 in Healthy Participants

Further study details as provided by Allakos, Inc.:

Primary Outcome Measures:
  • Safety and tolerability of AK002 as assessed by incidence, nature and severity of AEs and SAEs. [ Time Frame: Screening to day 112 ]

Secondary Outcome Measures:
  • Evaluate pharmacokinetic parameter AUC for AK002. [ Time Frame: Baseline to Day 112 ]
  • Change from baseline of absolute peripheral blood counts of eosinophils. [ Time Frame: baseline to Day 112 ]
  • Change from baseline of absolute peripheral blood counts of basophils. [ Time Frame: baseline to Day 112 ]
  • Changes in serum tryptase levels [ Time Frame: baseline to Day 112 ]
  • Evaluate pharmacokinetic parameter CMAX for AK002. [ Time Frame: baseline to day 112 ]
  • Changes in Eosinophilic Cationic protein levels [ Time Frame: Baseline to day 112 ]

Estimated Enrollment: 56
Study Start Date: August 2016
Estimated Study Completion Date: October 2017
Estimated Primary Completion Date: June 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: AK002
AK002 will be administered as an intravenous (IV) infusion in 8 cohorts of single escalating doses and two cohorts with multiple doses
Drug: AK002
IV AK002
Placebo Comparator: Placebo
Placebo administered as anl IV infusion
Other: Placebo

Detailed Description:

Participants who meet all inclusion and none of the exclusion criteria will be enrolled in the study. Safety and tolerability will be evaluated throughout the study. Blood sampling for PK and PD analysis will be also collected during the course of the study.

Up to approximately 48 participants will be enrolled in the study. Participants will be screened from -28 days prior to dose administration.

Participants will be admitted to the unit on Day -1 and will remain confined to the clinic until completion of Day 4 procedures. On Day 1, participants will receive a single dose of AK002 or placebo and complete study procedures. Participants will return to the clinic for follow up at Days 7, 14, 28, 56, 84 and 112 or end of study (EOS) visit.

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. Normal healthy volunteers, age at screening 18 to 65 years, inclusive.
  2. Determined by the Investigator to be in good health, as documented by medical history, physical examination (including, but not limited to, an evaluation of the cardiovascular, gastrointestinal, respiratory and central nervous systems), vital sign assessments, clinical laboratory assessments, and by general observations.
  3. Participants must weigh at least 50 kg and have a Body Mass Index (BMI) between 18 and 30 kg/m2 Inclusive.
  4. Participants must have clinical laboratory values within <1.5 x upper limit of normal (ULN) as specified by the testing laboratory, unless deemed not clinically significant by the Investigator.
  5. Consumed an average of no more than 3 drinks per day within the 6 months prior to administration of study drug (beer [284 mL], wine [125 mL] or distilled spirits [25 mL]).
  6. Participants must have a negative urine drug screen /alcohol breath test at screening and Day -1.
  7. Stool sample negative for parasites.
  8. Participants must have the ability and willingness to attend the necessary visits to the study centre.
  9. Written informed consent signed prior to entry into the study.
  10. Participants must be able to communicate effectively with the study site personnel.
  11. Participants using highly effective, double barrier contraception (both male and female partners) during the study and for 90 days following the dose of AK002

Exclusion Criteria:

  1. Positive testing for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C antibodies (HCV).
  2. The participant has any underlying physical or psychological medical condition that, in the opinion of the Investigator, would make it unlikely that the participant will complete the study.
  3. The participant has evidence of any medical or surgical disease or condition which, in the opinion of the Investigator, might compromise the haematologic, cardiovascular, pulmonary, renal, gastrointestinal, hepatic, skeletal, or central nervous system; or other conditions that may interfere with the absorption, distribution, metabolism or excretion of AK002, or would place the participant at increased risk.
  4. The participant has a history of cancer, except basal cell carcinoma which has been in remission for at least 5 years prior to Day 1
  5. Use of any new drugs (including prescription and over-the-counter drugs and herbal supplements) within 1 week or 5 half-lives (whichever is longer), prior to administration of study drug.
  6. Use of any prescription medication or neutraceuticals within 30 days of randomization.
  7. Use of over-the counter medication (with the exception of paracetamol), vitamin supplements, or herbal medicines within 7 days of randomization.
  8. Participants who initiated immunotherapy 90 days or more before the Screening visit and have been on a monthly regimen for allergy prevention or treatment may be considered for inclusion,
  9. Use of immunosuppressants, oral corticosteroids, angiotensin converting enzyme (ACE) inhibitors or beta blockers within 2 weeks or 5 half-lives (whichever is longer), prior to Screening.
  10. Any clinically significant laboratory abnormality or ECG.
  11. The participant has a known hypersensitivity to any component of the formulation of AK002.
  12. Absolute neutrophil count <1500/microliter.
  13. Aspartate aminotransferase (AST) or alanine transaminase (ALT) >1.5 x ULN unless deemed not clinically significant by Investigator discretion.
  14. The participant has history or presence of alcoholism or drug abuse within the 2 years prior to the first study drug administration, or is unwilling to agree to abstain from alcohol limitations and drugs throughout the study.
  15. The participant has used nicotine-containing products (including but not limited to cigarettes, pipes, cigars, chewing tobacco, nicotine patch or nicotine gum) within 3 months prior to Check-in (Day -1). Cotinine urine test is positive at Screening or Check-in (Day -1).
  16. The participant has poor peripheral venous access.
  17. Blood donation or significant blood loss (more than 500 mL) within 60 days
  18. Plasma donation within 7 days prior to Day 1.
  19. Administration of Investigational Product (IP) in another trial within 30 days prior to the first study drug administration (or within 5 half lives of the drug, whichever is longer).
  20. Females who are pregnant or lactating or intend to become pregnant before, during, or within 90 days after participating in this study; or intending to donate ova during such time period.
  21. Surgery within the past three months prior to the first study drug administration determined by the PI to be clinically relevant.
  22. Failure to satisfy the PI of fitness to participate for any other reason.
  23. History of severe allergic or anaphylactic reactions.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT02859701

Contacts
Contact: Study Lead C.Williams@nucleusnetwork.com.au

Locations
Australia
Nucleus Network Limited Recruiting
Melbourne, Australia
Contact: Principal Investigator       j.lickliter@nucleusnetwork.com.au   
Contact: Study Lead         
Sponsors and Collaborators
Allakos, Inc.
Investigators
Principal Investigator: Jason Lickliter, MBBS PhD Nucleus Network Ltd
  More Information

Responsible Party: Allakos, Inc.
ClinicalTrials.gov Identifier: NCT02859701     History of Changes
Other Study ID Numbers: AK002-002
Study First Received: July 13, 2016
Last Updated: January 18, 2017
Individual Participant Data  
Plan to Share IPD: Undecided

ClinicalTrials.gov processed this record on March 24, 2017