Study of the Expression of Heat Shock Proteins in Populations of B Lymphocytes in Human Tonsils (HOTLYMPHO)
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|ClinicalTrials.gov Identifier: NCT02859090|
Recruitment Status : Unknown
Verified August 2016 by Centre Hospitalier Universitaire Dijon.
Recruitment status was: Recruiting
First Posted : August 8, 2016
Last Update Posted : August 8, 2016
It has recently been shown that various HSPs are strongly expressed in B lymphomas. Indeed, HSP90 stabilizes the protein Bcl-6 in diffuse large-cell B lymphomas. Pharmacological inhibition of HSP90 in vitro induced apoptosis in lymphoma cells (Cerchietti et al. Nat. Medicine, 2009, 1369-1376). In addition, HSP110 is strongly expressed in non-Hodgkin lymphomas, and targeting this HSP at the cell surface using specific antibodies could constitute a future therapy (Zappasodi et al. Blood, 2011, 4421-4430). Despite the importance of these proteins in the development of lymphomas, their expression and their role in the activation of normal B lymphocytes and the normal development of germinal centres is not known.
The expression of Heat shock proteins should vary among the different B lymphocyte populations present in the tonsils (naïve B cells, memory B cells, germinal centre B cells).
The aim of this study is to establish an expression profile for heat shock proteins in populations of B lymphocytes in human tonsils
|Condition or disease||Intervention/treatment||Phase|
|Tonsillectomy||Procedure: tonsillectomy Biological: blood sample||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||30 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Single-centre Study of the Expression of Heat Shock Proteins in the Lymphocytes From the Tonsils of Patients With Various Diseases Requiring Tonsillectomy|
|Study Start Date :||August 2014|
|Estimated Primary Completion Date :||August 2017|
Biological: blood sample
- expression of heat shock proteins [ Time Frame: Day one ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02859090
|Contact: Christian DUVILLARDemail@example.com|
|CHU Dijon Bourgogne||Recruiting|
|Dijon, France, 21079|
|Contact: Christian DUVILLARD firstname.lastname@example.org|