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Study of the Expression of Heat Shock Proteins in Populations of B Lymphocytes in Human Tonsils (HOTLYMPHO)

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ClinicalTrials.gov Identifier: NCT02859090
Recruitment Status : Recruiting
First Posted : August 8, 2016
Last Update Posted : August 8, 2016
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier Universitaire Dijon

Brief Summary:

It has recently been shown that various HSPs are strongly expressed in B lymphomas. Indeed, HSP90 stabilizes the protein Bcl-6 in diffuse large-cell B lymphomas. Pharmacological inhibition of HSP90 in vitro induced apoptosis in lymphoma cells (Cerchietti et al. Nat. Medicine, 2009, 1369-1376). In addition, HSP110 is strongly expressed in non-Hodgkin lymphomas, and targeting this HSP at the cell surface using specific antibodies could constitute a future therapy (Zappasodi et al. Blood, 2011, 4421-4430). Despite the importance of these proteins in the development of lymphomas, their expression and their role in the activation of normal B lymphocytes and the normal development of germinal centres is not known.

The expression of Heat shock proteins should vary among the different B lymphocyte populations present in the tonsils (naïve B cells, memory B cells, germinal centre B cells).

The aim of this study is to establish an expression profile for heat shock proteins in populations of B lymphocytes in human tonsils


Condition or disease Intervention/treatment Phase
Tonsillectomy Procedure: tonsillectomy Biological: blood sample Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 30 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Official Title: Single-centre Study of the Expression of Heat Shock Proteins in the Lymphocytes From the Tonsils of Patients With Various Diseases Requiring Tonsillectomy
Study Start Date : August 2014
Estimated Primary Completion Date : August 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Shock Tonsillitis

Arm Intervention/treatment
Experimental: patient Procedure: tonsillectomy
Biological: blood sample



Primary Outcome Measures :
  1. expression of heat shock proteins [ Time Frame: Day one ]


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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Persons who have provided oral consent
  • Tonsillectomy in children or adults

Exclusion Criteria:

  • Persons without national health insurance cover
  • Adults under guardianship
  • Pregnant or breast-feeding women
  • Persons with positive HIV or HCV serology

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02859090


Contacts
Contact: Christian DUVILLARD christian.duvillard@chu-dijon.fr

Locations
France
CHU Dijon Bourgogne Recruiting
Dijon, France, 21079
Contact: Christian DUVILLARD       christian.duvillard@chu-dijon.fr   
Sponsors and Collaborators
Centre Hospitalier Universitaire Dijon

Responsible Party: Centre Hospitalier Universitaire Dijon
ClinicalTrials.gov Identifier: NCT02859090     History of Changes
Other Study ID Numbers: DUVILLARD UB 2012
First Posted: August 8, 2016    Key Record Dates
Last Update Posted: August 8, 2016
Last Verified: August 2016