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Combined Use of Er:YAG and Nd:YAG Laser

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ClinicalTrials.gov Identifier: NCT02851823
Recruitment Status : Completed
First Posted : August 2, 2016
Results First Posted : November 7, 2017
Last Update Posted : November 7, 2017
Sponsor:
Collaborator:
Tubitak
Information provided by (Responsible Party):
Dr. Mehmet Sağlam, Izmir Katip Celebi University

Brief Summary:
The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planning with hand instruments in nonsurgical treatment of chronic periodontitis.

Condition or disease Intervention/treatment Phase
Chronic Periodontitis Device: Periodontal curettes Device: Er-YAG+Nd-YAG lasers Not Applicable

Detailed Description:
The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planning with hand instruments in nonsurgical treatment of chronic periodontitis.Twenty-five systemically healthy patients with moderate-to-advanced periodontal destruction were selected for this study. The quadrants were randomly allocated in a split-mouth design to either combined Er:YAG (160 mj/pulse, and 10 Hz) and Nd:YAG laser (100 mJ/pulse, and 20 Hz) therapy (test group) or scaling root planning using hand instruments (control group). At baseline, 1 month, and 3 months after treatment, clinical measurements, including plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (%) (BOP), were performed and gingival crevicular fluid and subgingival plaque samples were taken. The gingival crevicular fluid levels of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were analyzed by enzyme-linked immunosorbent assay. Total antioxidant status (TAS)/total oxidant status (TOS) were analyzed by high-performance liquid chromatography and a novel automatic colorimetric method. Quantitative analysis of Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), and Treponema denticola (Td) was performed using real-time polymerase chain reaction (PCR) procedures.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 25 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description: split-mouth
Masking: Double (Care Provider, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Combined Application of ER:YAG and ND:YAG Lasers in Treatment of Chronic Periodontitis: A Split-mouth Randomized Controlled Trial
Study Start Date : October 2014
Actual Primary Completion Date : October 2015
Actual Study Completion Date : April 2016

Arm Intervention/treatment
Active Comparator: Control Group
Mechanical periodontal treatment: Scaling and root planing were performed with periodontal curettes until the operator feels that root surface is clean, hard and smooth.
Device: Periodontal curettes
Other Name: Hu-Friedy, Gracey curets No. 1/2, 3/4, 5/6, 7/8, 11/12, 13/14, Hu-Friedy Ins. Co., USA

Experimental: Test Group
Combined laser therapy: An Er:YAG laser (160 mj/pulse, 10 Hz) (AT Fidelis Fotona, Ljubljana, Slovenia) with water irrigation was first used to remove subgingival calculus and infected cementum.The Er:YAG laser beam was delivered into the periodontal pockets using a chisel-shaped quartz tip in contact mode under water irrigation, from a coronal to an apical direction with the tip inclined at 10o to 15o to the root surfaces. After Er:YAG laser application, Nd:YAG laser treatment (AT Fidelis Fotona, Ljubljana, Slovenia) was performed at an energy level of 100 mJ/pulse, and 20 Hz for removing pocket epithelium and detoxification purpose. Irradiation was accomplished with a 320 μm fiber optic delivery system. The fiber was inserted into the periodontal pocket base in parallel alignment with the root surface, and the fiber was slowly moved from apical to coronal in a sweeping motion during the laser light emission.
Device: Er-YAG+Nd-YAG lasers
Other Name: AT Fidelis Fotona, Ljubljana, Slovenia




Primary Outcome Measures :
  1. Clinical Attachment Level Change for Moderately Deep Pockets (4 mm≤PD≤6 mm) [ Time Frame: Baseline, 1 and 3 months ]
    Change in clinical attachment level for moderately deep pockets (4 mm≤PD≤6 mm) between baseline and 1 month Change in clinical attachment level for moderately deep pockets (4 mm≤PD≤6 mm) between baseline and 3 month

  2. Clinical Attachment Level Change for Deep Pockets (7 mm≤PD) [ Time Frame: Baseline, 1 and 3 months ]

    Change in clinical attachment level for deep pockets (7 mm≤PD) between baseline and 1 month.

    Change in clinical attachment level for deep pockets (7 mm≤PD) between baseline and 3 month.




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Ages Eligible for Study:   19 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • The patients had ≥4 teeth per quadrant with probing depth (PD) of ≥5 mm, clinical attachment level (CAL) of ≥4 mm, and radiographic signs of alveolar bone loss. These individuals also had bleeding on probing (BOP) at >80% of the proximal sites.

Exclusion Criteria:

  • Periodontal treatment received for the last 1 year; systemic diseases that could influence the outcome of the therapy, pregnancy, smoking, immunosuppressive chemotherapy; and use of antibiotics and anti-inflammatory drugs for the last 6 months.

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Responsible Party: Dr. Mehmet Sağlam, Principal investigator, Department of Periodontology, Faculty of Dentistry, Izmir Katip Celebi University, Izmir Katip Celebi University
ClinicalTrials.gov Identifier: NCT02851823     History of Changes
Other Study ID Numbers: 114S767
First Posted: August 2, 2016    Key Record Dates
Results First Posted: November 7, 2017
Last Update Posted: November 7, 2017
Last Verified: October 2017

Keywords provided by Dr. Mehmet Sağlam, Izmir Katip Celebi University:
Er-YAG lasers
Nd-YAG lasers
chronic periodontitis
nonsurgical periodontal debridement

Additional relevant MeSH terms:
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Periodontitis
Chronic Periodontitis
Periodontal Diseases
Mouth Diseases
Stomatognathic Diseases