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Therapeutic Efficacy of Categorical Language Fluency Smartphone Game Application

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ClinicalTrials.gov Identifier: NCT02848404
Recruitment Status : Enrolling by invitation
First Posted : July 28, 2016
Last Update Posted : April 4, 2019
Sponsor:
Collaborators:
Seoul National University
Ministry of Science, ICT and Future Planning
Information provided by (Responsible Party):
Ki Woong Kim, Seoul National University Bundang Hospital

Brief Summary:
The purpose of this study is to examine therapeutic efficacy of catergorical language fluency smartphone game apllication in mild congnitive imapirment and mild Alzheimer's dementia.

Condition or disease Intervention/treatment Phase
Mild Cognitive Impairment Alzheimer's Disease Device: Categorical Language Fluency Smartphone Application Not Applicable

Detailed Description:
The Categorical Language Fluency Smartphone Game Application was developed based on the semantic distance training, which was effective in improving categorical language fluency of mild cognitive impairment and mild Alzheimer's dementia. 10 patients with mild cognitive impairment and another 10 patients with mild Alzheimer's dementia were recruited to examine therapeutic efficacy of the application.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Study of Therapeutic Efficacy of Categorical Language Fluency Smartphone Game Application in Mild Cognitive Impairment and Mild Alzheimer's Dementia (Baseline Study)
Study Start Date : June 2016
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : March 2020


Arm Intervention/treatment
Experimental: Categorical Language Fluency Smartphone Application
Smartphone game application specifically aimed at training categorical language fluency
Device: Categorical Language Fluency Smartphone Application
4 weeks' training




Primary Outcome Measures :
  1. Application usage log [ Time Frame: 4-weeks treatment ]
    Log to assess compliance of participant(by describing frequency and duration of training by using application)


Secondary Outcome Measures :
  1. Subjective Memory Complaint Questionnaire [ Time Frame: after 4-weeks treatment ]
    to evaluate efficacy of application

  2. Geriatric Depression Scale [ Time Frame: after 4-weeks treatment ]
    to evaluate efficacy of application

  3. Korean version of MMSE for dementia screening [ Time Frame: after 4-weeks treatment ]
    to evaluate efficacy of application



Information from the National Library of Medicine

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Ages Eligible for Study:   55 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Aged above 55
  • Confirmed literacy

    • Diagnosed to mild cognitive imapirment by Internatinoal Working Group on Mild Cognitive Impairment and Clinical Dementia Rating(CDR) of 0 or 0.5.
    • Diagnosed to possible or probable Alzheimer's dementia by NINCDS-ADRDA and Clinical Dementia Raing(CDR) of 1 or below.

Exclusion Criteria:

  • Evidence of delirium, confusion
  • Any neurological conditions causing cognitive decline such as Parkinson's disease, brain hemorrhage, brain tumor, normal pressure hydrocephalus
  • Evidence of severe cerebrovascular pathology
  • History of loss-of-consciousness over 1 hour due to head trauma or repetitive head trauma of mild severity
  • History of substance abuse or dependence such as alcohol
  • Presence of depressive symptoms that could influence cognitive function
  • Presence of medical comorbidities that could result in cognitive decline

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02848404


Sponsors and Collaborators
Seoul National University Bundang Hospital
Seoul National University
Ministry of Science, ICT and Future Planning
Investigators
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Principal Investigator: Ki Woong Kim, M.D., Ph.D. Seoul National University Bundang Hospital, Seong-nam, Korea

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Responsible Party: Ki Woong Kim, Professor, department of neuropsychiatry, Seoul National University Bundang Hospital
ClinicalTrials.gov Identifier: NCT02848404     History of Changes
Other Study ID Numbers: 2010-0028631
First Posted: July 28, 2016    Key Record Dates
Last Update Posted: April 4, 2019
Last Verified: April 2019

Keywords provided by Ki Woong Kim, Seoul National University Bundang Hospital:
Mild cognitive impairment
Cognitive rehabilitation
Cognitive therapy
Alzheimer's disease
Memory enhancement
Categorical language fluency

Additional relevant MeSH terms:
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Alzheimer Disease
Cognitive Dysfunction
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Cognition Disorders