Multi-scale Modeling of Sleep Behaviors in Social Networks

• ClinicalTrials.gov Identifier: NCT02846077
• Recruitment Status: Completed
• First Posted: July 27, 2016
• Last Update Posted: July 11, 2018
• Sponsor: Brigham and Women's Hospital
• Collaborators: Massachusetts Institute of Technology; Harvard University
• Information provided by (Responsible Party): Elizabeth B. Klerman, Brigham and Women's Hospital

Study Description

Brief Summary:

The project is designed to document in college undergraduates the relationships among sleep/wake timing and duration, use of mobile phones and other electronic devices, food timing and content, self-reported mood and physiological measures.

Condition or disease	Intervention/treatment
Healthy Volunteers	Other: No intervention. Observation only

Detailed Description:

College undergraduates are studied in cohorts of ~ 50 in fall or spring semesters. They complete diaries once in the morning and once in the evening about sleep/wake timing, timing of social and school activities, and mood. They wear physiological sensors. They install (1) an application on their mobile phone that tracks timing, duration and de-identified sender/recipient of phone calls and text messages, use of internet or apps (but not the content or names of those internet sites and apps) and (2) meal content and timing. They also spend at least one overnight session providing saliva samples for later assay for hormones.

Study Design

• Study Type: Observational
• Actual Enrollment: 729 participants
• Observational Model: Cohort
• Time Perspective: Prospective
• Official Title: Multi-scale Modeling of Sleep Behaviors in Social Networks
• Actual Study Start Date: September 2013
• Actual Primary Completion Date: June 2018
• Actual Study Completion Date: June 2018

Groups and Cohorts

Group/Cohort	Intervention/treatment
College students; College students will be monitored and will complete online surveys, install apps on their mobile phones, wear physiological sensors and provide saliva samples for later assay.	Other: No intervention. Observation only; No intervention. Observation only

Outcome Measures

Primary Outcome Measures :

1. Timing of sleep and wake [ Time Frame: Approximately one month ]
   Timing of self-reported sleep onset and wake onset
2. Timing of phone use (e.g., mobile phone calls, text messages, applications and internet use) [ Time Frame: Approximately one month ]
   Timing of phone use (e.g, mobile phone calls, text messages, applications and internet use)

Secondary Outcome Measures :

1. Mood [ Time Frame: Approximately one month ]
   Self-reported mood using a linear non-numeric scale
2. Activity levels [ Time Frame: approximately one month ]
   Activity levels collected every minute using a wrist-worn device
3. Light exposure levels [ Time Frame: approximately one month ]
   Light exposure levels collected every minute using a wrist-worn device
4. Food choice [ Time Frame: approximately one month ]
   Content of food
5. Circadian phase [ Time Frame: one day ]
   Calculated time of melatonin phase as a marker of circadian rhythms
6. Electrodermal activity [ Time Frame: approximately one month ]
   Electrodermal activity as measured using a wrist-worn device
7. Timing of meals [ Time Frame: approximately one month ]
   Time meals are eaten

Biospecimen Retention:   Samples Without DNA

Saliva

Eligibility Criteria

• Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes
• Sampling Method: Non-Probability Sample

Study Population

College undergraduates

Criteria

Inclusion Criteria:

• undergraduate at institution at which we have permission to perform study
• owning a mobile device on which the phone app can be installed
• ability to wear the wrist-worn sensors

Exclusion Criteria:

• no travel outside one time zone starting approximately 2 weeks before monitoring begins through end of approximately one month of monitoring.
• participation in a prior group studied

Contacts and Locations

Locations

United States, Massachusetts

Brigham and Women's Hospital

Boston, Massachusetts, United States, 02115

Sponsors and Collaborators

Brigham and Women's Hospital

Massachusetts Institute of Technology

Harvard University

Investigators

• Principal Investigator: Elizabeth B Klerman, MD PhD; Brigham and Women's Hospital

More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Fischer D, McHill AW, Sano A, Picard RW, Barger LK, Czeisler CA, Klerman EB, Phillips AJK. Irregular sleep and event schedules are associated with poorer self-reported well-being in US college students. Sleep. 2020 Jun 15;43(6). pii: zsz300. doi: 10.1093/sleep/zsz300.

McHill AW, Phillips AJ, Czeisler CA, Keating L, Yee K, Barger LK, Garaulet M, Scheer FA, Klerman EB. Later circadian timing of food intake is associated with increased body fat. Am J Clin Nutr. 2017 Nov;106(5):1213-1219. doi: 10.3945/ajcn.117.161588. Epub 2017 Sep 6.

• Responsible Party: Elizabeth B. Klerman, Associate Professor, Brigham and Women's Hospital
• ClinicalTrials.gov Identifier: NCT02846077
• Other Study ID Numbers: BrighamHospital
• First Posted: July 27, 2016
• Last Update Posted: July 11, 2018
• Last Verified: July 2018

Individual Participant Data (IPD) Sharing Statement:

• Plan to Share IPD: Undecided

Keywords provided by Elizabeth B. Klerman, Brigham and Women's Hospital:

sleep; social networks; undergraduates; mood; circadian rhythms