Endophenotype Characterization of a Family Psychiatric Disorder (EnBiGen)
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|ClinicalTrials.gov Identifier: NCT02843997|
Recruitment Status : Unknown
Verified July 2016 by University Hospital, Grenoble.
Recruitment status was: Recruiting
First Posted : July 26, 2016
Last Update Posted : July 26, 2016
Bipolar disorder is a chronic and frequent mood pathology, that impacts on emotional and socio-professional life of sick subjects, and also increase mortality by suicide. Suicide is considered as a bipolar disorder result.
The main goal of this study is the endophenotype characterization from a clinical and cognitive point of view, of a bipolar spectrum's disorder present in a family, and then highlight a mutation of one of the genes involved is this disorder.
|Condition or disease||Intervention/treatment||Phase|
|Healthy Volunteer||Genetic: Endophenotype and sequencing||Not Applicable|
Heritability of bipolar disorder is now well established, but seems to be multifactorial in most of the cases.
The use of an endophenotype characterized in a family presenting numerous bipolar sufferers enable to reflect the expression of simpler genetic variants than those involved in the disease, and might enable the identification of genes involved in the etiopathogenesis of this endophenotype.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||29 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Endophenotype Characterization of a Family Psychiatric Disorder of the Bipolar Spectrum, With an Autosomal Dominant Expression|
|Study Start Date :||February 2015|
|Estimated Primary Completion Date :||February 2018|
|Estimated Study Completion Date :||February 2018|
Members of a family
Genetic: Endophenotype and sequencing
Draw an endophenotype and genetic study
- Neuropsychological evaluations tests [ Time Frame: One day ]
Neuropsychological evaluations (about one hour) :
TMT (Trail Making Test) A and B, Stroop VFT (Visual Field Testing), DST (Dyslexia Screening Test) Tower of London test Hayling, CPT (continuous performance task) CVLT (California Verbal Learning Test) tests.
- Eye tracking. [ Time Frame: One hour ]
The volunteer will follow an instruction according to the color seen on a screen.
This instruction is to look at the side where there is a flashlight and to look at the opopsite if the light is unbroken.
Mistakes will be count.
- Blood sampling [ Time Frame: 3 minutes ]Genetic sample for extraction of DNA.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02843997
|Contact: Jérôme Holtzmann, Doctor||04 76 76 54 email@example.com|
|Contact: John Rendu, Doctor||04 76 76 55 firstname.lastname@example.org|
|La Tronche, France, 38700|
|Contact: Jérôme Holtzmann, Doctor 04 76 76 54 14 JHoltzmann@chu-grenoble.fr|
|Contact: John Rendu 04 76 76 55 73 email@example.com|
|Principal Investigator:||Jérôme Holtzmann, Doctor||Grenoble Hospital University|