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Subjective Perception of Motor Control During Psychogenic Disorders (PERCMO-TNF)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02843932
Recruitment Status : Terminated (recruitment difficulties)
First Posted : July 26, 2016
Last Update Posted : November 18, 2020
Information provided by (Responsible Party):
University Hospital, Grenoble

Brief Summary:

The aim of this study is to reveal neurobiological bases of the motor control of conscious perception, thanks to new techniques of functional cerebral imaging (MRI), and potentials deteriorations connected to neuropsychiatric disorders like conversion disorder.

The Hospital University Center of Grenoble will provide patients from Neurology department, characterized with non psychogenic epileptic seizures and abnormal psychogenic movements, from conversive origin.

Subjects will be scanned by Magnetic Resonance Imaging during a motor paradigm inducing a perceptive conflict between two informations : proprioceptive information coming from the action (drawing) and visual information (draw's mark) that appears on the screen when there is movement.

Condition or disease Intervention/treatment Phase
Somatoform Disorders Other: functional brain MRI Not Applicable

Detailed Description:
New results will be provided about brain mechanisms involved in motor control perception among healthy patients and patients suffering from functional neurologic symptoms.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 14 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Study of Subjective Perception of Motor Control During Psychogenic Disorders : Brain Mechanisms and Functional Imaging.
Actual Study Start Date : May 13, 2015
Actual Primary Completion Date : June 2019
Actual Study Completion Date : June 2019

Arm Intervention/treatment
Experimental: Psychogenic disorders
Psychogenic movement disorders and seizures
Other: functional brain MRI
functional imagery during motor-perception tasks

Primary Outcome Measures :
  1. Familiarization with the joystick. [ Time Frame: 30 minutes ]
    HHSC-JOY-I from Current Designs. They are asked to trace a straight line.

  2. Brain MRI [ Time Frame: One hour and a half ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Signed informed consent
  • Medical exam médical done before study participation
  • Between 18 and 65 years
  • Right-handed persons
  • Conversion disorder based on DSM IV-R criterias
  • Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking)

Exclusion Criteria:

  • Subjects included in a clinical and/or therapeutic exeprimentation in progress
  • People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia
  • Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale
  • History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding.
  • Alcohol ingestion
  • Pregnant, parturient or breastfeeding women
  • All other categories of protected persons

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02843932

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Chu Grenoble
Grenoble, France, 38043
Sponsors and Collaborators
University Hospital, Grenoble
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Study Chair: Tiphaine Montagnon DRCI, CHU GRENOBLE, FRANCE
Cojan Y, Vuilleumier P. Functional brain imaging of psychogenic paralysis during conversion and hypnosis
Hallet M, cloninger CR, Fahn S, Halligan P, Jankovic J, Lang AE, Voon V Psychogenic movement disorders and other conversion disorders. Cambridge University Press 2011

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Responsible Party: University Hospital, Grenoble Identifier: NCT02843932    
Other Study ID Numbers: 38RC14.120*
First Posted: July 26, 2016    Key Record Dates
Last Update Posted: November 18, 2020
Last Verified: November 2020
Keywords provided by University Hospital, Grenoble:
Additional relevant MeSH terms:
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Somatoform Disorders
Mental Disorders