Effect of Stimulation of the Prefrontal Cortex on Language Production in Aphasic Patients
|ClinicalTrials.gov Identifier: NCT02840370|
Recruitment Status : Completed
First Posted : July 21, 2016
Last Update Posted : October 26, 2017
|Condition or disease||Intervention/treatment||Phase|
|Aphasia||Device: transcranial direct current stimulation Device: Sham tDCS||Not Applicable|
Language processing is a complex brain function supported by a large network, including domain-specific language areas as well as domain-general cognitive-control networks (Friederici & Gierhan, 2013). Noninvasive brain stimulation, such as transcranial direct current stimulation (tDCS), is increasingly being used as a promising therapeutic tool for psychiatric and neurological diseases (Tortella et al., 2015; Flöel, 2014). In the language domain, several studies revealed that tDCS over languagespecific areas induces changes in cortical function that enhances the recovery of language abilities in patients with post-stroke aphasia (Torres, Drebing & Hamilton, 2013; Monti et al., 2013). Beneficial effects of tDCS have also been found for stimulation over more domain-general cognitive control regions. Although research on non-invasive brain stimulation and aphasia reveals promising results, studies investigating the modulation of cognitive control-networks on lexical access are rare. Given the importance of a successful interplay between prefrontal and domain-specific language areas, possible therapeutic effects of tDCS over the prefrontal cortex (PFC) in aphasia can be of high value for rehabilitation and basic research.
A planned total of 30 patients will be included. In a first visit, the severity of aphasia, the medical history as well as inclusion/exclusion criteria will be evaluated. After this visit, patients will undergo two tDCS sessions (one tDCS and one S-tDCS session) with a one week interval between the sessions. Each session consists of an online (during stimulation) and an offline assessment (within 30 minutes after stimulation). Three language tasks and a nonverbal executive function task will be conducted online as well as offline in each of the two sessions (tDCS and S-tDCS).
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||19 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Effect of Transcranial Direct Current Stimulation of the Prefrontal Cortex on Language Production in Aphasic Patients: a Multicentre Experimental Study With a Placebo-controlled and Double Blind Crossover Design|
|Study Start Date :||May 2016|
|Actual Primary Completion Date :||March 2017|
|Actual Study Completion Date :||September 2017|
Experimental: transcranial direct current stimulation
Device: transcranial direct current stimulation
In tDCS, the prefrontal cortex is stimulated during 20minutes through a weak constant electric current (1-2 mA) through two electrodes in a non-invasive and painless manner.
Sham Comparator: Sham tDCS
Device: Sham tDCS
S-tDCS refers to a control condition in which the subject will receive a brief current in the beginning in order to induce a similar sensation on the scalp as in tDCS, and then the stimulator remains off for the rest of the stimulation time.
- Language production [ Time Frame: up to 30 min ]Picture naming task, repetition task and verbal fluency task
- Nonverbal executive functions task [ Time Frame: up to 30 min ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02840370
|Laboratory for Cognitive and Neurological Sciences|
|Fribourg, Switzerland, 1700|
|Hôpital Cantonal de Fribourg|
|Fribourg, Switzerland, 1708|
|University Hospital Geneva|
|Geneva, Switzerland, 1206|
|Principal Investigator:||Jean-Marie Annoni, Prof. Dr.||University of Fribourg|