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Cortical Activation in Individuals With Finger Amputation During Mirror Versus Imagery Treatment

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ClinicalTrials.gov Identifier: NCT02838485
Recruitment Status : Unknown
Verified July 2016 by Hadassah Medical Organization.
Recruitment status was:  Not yet recruiting
First Posted : July 20, 2016
Last Update Posted : July 20, 2016
Sponsor:
Collaborator:
Tel Aviv University
Information provided by (Responsible Party):
Hadassah Medical Organization

Brief Summary:

Goals : ( a) to examine differences in cortical activity during hand movements with a mirror compared to imagery of the same movements, and (b) to examine correlation between cortical activity during imagery or mirror treatment and the pain and performance measures in finger amputees.

A cross-sectional study of 20 subjects in a Functional Magnetic Resonance Imaging (fMRI) preforming mirror therapy hand movement and imagery hand movement. Also, Visual Analogue Scale for pain and the Disability of the Arm, Shoulder and Hand (DASH) questionnaire and Jebsen Taylor Hand Function Test will be used.


Condition or disease Intervention/treatment Phase
Amputees Other: Mirror Other: Imagery Not Applicable

Detailed Description:

Goals : ( a) to examine differences in cortical activity during hand movements with a mirror compared to imagery of the same movements, and (b) to examine correlation between cortical activity during imagery or mirror treatment and the pain and performance measures in finger amputees.

A cross-sectional one-meeting study of 20 subjects (finger amputees) in a Functional Magnetic Resonance Imaging (fMRI) preforming mirror therapy hand movement and imagery hand movement. Also, Visual Analogue Scale for pain and the Disability of the Arm, Shoulder and Hand (DASH) questionnaire and Jebsen Taylor Hand Function Test will be used.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 20 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Cortical Activation in Individuals With Finger Amputation During Mirror Versus Imagery Treatment
Study Start Date : August 2016
Estimated Primary Completion Date : August 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Limb Loss

Arm Intervention/treatment
Experimental: Amputees
The subjects will receive both mirror and imagery treatments in a cross-over design.
Other: Mirror
The healthy hand will be mirrored and the amputated hand unseen by the subject while performing hand movements.

Other: Imagery
The subject will be asked to imagine performing hand movements.




Primary Outcome Measures :
  1. Cortical activity [ Time Frame: 1 hour ]
    Activation of supplementary motor area (SMA), S1 and M1.


Secondary Outcome Measures :
  1. Visual analogue scale [ Time Frame: 10 minutes ]
    Filled by the subject for subjective pain in residuum discomfort.

  2. Disability of the Arm, Shoulder and Hand [ Time Frame: 30 minutes ]
    Questionnaire regarding the disability and daily activities difficulties.

  3. The Jebsen Taylor Hand Function Test [ Time Frame: 30 minutes ]
    Standard evaluation of hands functionality.



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Ages Eligible for Study:   18 Years to 67 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Following unilateral traumatic finger or fingers amputation (1 to 3 fingers)
  • Self-reported limited functionality, sensory disorder or pain

Exclusion Criteria:

  • Are not comparable with MRI restrictions
  • Chronic pain disease
  • Psychiatric condition

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02838485


Contacts
Contact: Isabella Schwartz, MD isabellas@hadassah.org.il
Contact: Hadas Lemberg, PhD 00 972 2 6777572 lhadas@hadassah.org.il

Locations
Israel
Hadassah Medical Center
Jerusalem, Israel, 91240
Sponsors and Collaborators
Hadassah Medical Organization
Tel Aviv University