Sleep, Autonomic Nervous System and Cardiorespiratory Capacity in Autism Spectrum Disorders Children (APAUTRES) (APAUTRES)
Autism Spectrum Disorders (ASD) is a neurodevelopmental disorder which involves social and behavioural impairments. Autonomic dysfunctions and disturbed sleep were often associated to ASD. The investigators proposed to explore the impact of physical activity on these disorders. In this context, it is necessary to characterize the cardiorespiratory capacities of ASD children in order to promote physical activity for this population. To examine potential differences between ASD and control children, some explorations were proposed: a maximal treadmill test, motor evaluation, and orthostatic test (for the evaluation of autonomic nervous system).
An actimetry during one week (evaluation of physical activity and sleep) completed this study in order to specify sleep characteristic and established the possible link between physical activity sleep characteristics and physical fitness in ASD children.
|Study Design:||Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: No masking
Primary Purpose: Diagnostic
|Official Title:||Sleep, Autonomic Nervous System and Cardiorespiratory Capacity in Autism Spectrum Disorders Children|
- cardiorespiratory evaluation [ Time Frame: 1 day ]a maximal treadmill test is proposed (evaluation of : VO² max, maximal heart rate)
- autonomic nervous system evaluation [ Time Frame: 1 day and 3 nights ]an orthostatic test is proposed in order to verify the ANS adaptation. A nocturnal recording is made during three nights in order to verify the possible link between the rest autonomic adaptations and a possible dysautonomia observed with the orthostatic test.
- sleep evaluation [ Time Frame: 7 nights ]
Sleep characteristics are obtained by an actimetry during 7 nights in order to observe sleep disorders.
Sleep Questionnaires are also completed.
- physical activity [ Time Frame: 7 days ]
physical activity characteristics (sedentary, moderate or vigorous activities, energy expenditure) are obtained by an actimetry during 7 days.
Questionnaires of physical activity are also completed
- Motor capacities [ Time Frame: 1 day ]motor capacities are evaluated by several specific tests : PANESS, M-ABS and Eurofit.
- Behavioural characteristics [ Time Frame: 1 hour ]Behavioural characteristics are evaluated by the Vineland scale
- biological parameters [ Time Frame: 1 day ]during the maximal treadmill test, salivary samples are made (cortisol, alpha amylase), before and after tthe test
|Study Start Date:||December 2013|
|Estimated Study Completion Date:||March 31, 2019|
|Estimated Primary Completion Date:||March 31, 2019 (Final data collection date for primary outcome measure)|
Children from 8 to 18 years with autism without without intellectual disabilities (IQ > 70), verbals and responding to classification CIM 10-DSM IV.
|Other: physiological explorations|
Experimental: Healthy volunteers
Paired for age, gender, IQ and and the practice of a physical activity strictly within the school context.
|Other: physiological explorations|
Please refer to this study by its ClinicalTrials.gov identifier: NCT02830022
|Contact: Véronique BRICOUT, PhD||+33 476 76 72 26||VBricout@chu-grenoble.fr|
|Contact: Claire BOLLART, ARC promotor||+334 76 76 56 09||CBollart@chu-grenoble.fr|
|Grenoble and Rhone Alps region, France, 38|
|Contact: Véronique Bricout, PhD +33476 76 72 26 VBricout@chu-grenoble.fr|
|Contact: Claire BOLLART, Arc +33 476 76 56 06 CBollart@chu-grenoble.fr|
|Principal Investigator:||Véronique BRICOUT, PhD||CHU Grenoble France|
|Principal Investigator:||Michel GUINOT, Dr||CHU Grenoble France|