Effects of Pregnenolone on Perceived Social Isolation
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No studies to date have examined the effects of pregnenolone on hypervigilance for social threat in individuals with perceived social isolation (PSI). We therefore are conducting a double-blind randomized research study combining three validated behavioral paradigms on social threat attention, perception of others, and emotion regulation with high-density electrical neuroimaging to probe the neuro-circuitry of social threat processing in young adults high in perceived social isolation two hours after the oral administration of 175mg pregnenolone (N = 24), 400mg of pregnenolone (N = 24), or placebo (N = 24). Such research has the potential to yield important insights into the neurobehavioral mechanisms of pregnenolone on hypervigilance for social threat and perception of others--- a first key step toward the development of adjunctive pregnenolone therapy in individuals with PSI.
Evoked Brain Potentials (measured brain response that is the direct result of a specific cognitive event). Change from baseline EEG results at 8 weeks. Average the electrical brain activity evoked by each type of stimuli to calculate the evoked brain potentials (any stereotyped electrophysical response to a stimulus).
Secondary Outcome Measures :
Eye movement tracking [ Time Frame: 8 weeks ]
Movements to first saccades. Change from baseline eye movement tracking results at 8 weeks.
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Layout table for eligibility information
Ages Eligible for Study:
21 Years to 80 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
At least a score of 42 on the UCLA Loneliness scale.
Normal or corrected eye sight
Medical history of cancer
History of heart irregularities
Have a counter indication to EEG
Age <21 or >32
Score less than 42 on UCLA loneliness scale
Meet MINI criteria for anything but untreated major depressive disorder
Current or past neurological disorder including epilepsy or traumatic brain injury
Have a counter indication to electrical neuroimaging
Under hormonal therapy (including, but not limited to, testosterone)
Unstable mental illness
History of bipolar disorder, schizophrenia, or psychotic disorder
Current or recent (past 3 months) substance use or dependence
Currently taking any medications that may have unfavorable interactions with pregnenolone