Etiology of Endocarditis in Negative Blood Cultures (ENDOC)
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|ClinicalTrials.gov Identifier: NCT02816307|
Recruitment Status : Recruiting
First Posted : June 28, 2016
Last Update Posted : June 28, 2016
Infective endocarditis remains a serious disease that requires fast and specialized support in 2012. However, 24% of endocarditis unanswered etiology. The systematic use of new policy diagnosis, including (i) a systematic use of specific PCR techniques and (ii) the search for markers of inflammatory and tumoral diseases, should increase the number of positive etiological diagnosis of culture-negative samples.
Secondly, because of the seriousness of the disease, the investigators were led to develop a new score: score for admission. This score, realized in less than 4 hours from the admission of the suspected patient with endocarditis, should allow for immediate probabilistic antibiotic treatment after completion of the diagnostic kit. The modified Duke score give its results in 4 to 7 days. With the score of admission thus diagnostic processes are accelerated and, where appropriate, empirical antibiotic therapy started.
Primary: Evaluate the effectiveness of the new diagnostic strategy on etiological identification of endocarditis.
Secondary: Validate the "admission" score compared to the modified Duke score.
|Condition or disease||Intervention/treatment|
|Infective Endocarditis (IE)||Other: blood samples|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||1830 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Etiology of Endocarditis in Negative Blood Cultures|
|Study Start Date :||March 2013|
|Estimated Primary Completion Date :||March 2019|
|Estimated Study Completion Date :||September 2019|
|Experimental: Infective endocarditis||Other: blood samples|
- The percentage of patients with an etiological diagnosis of endocarditis [ Time Frame: 6 years ]
- The "admission" score [ Time Frame: 1 day ]
- the Duke score [ Time Frame: 1day ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02816307
|Contact: jean-paul CASALTAfirstname.lastname@example.org|
|Contact: ALEXANDRA GIULIANIemail@example.com|
|Assitance Publique Hopitaux de Marseille||Recruiting|
|Marseille, France, 13|
|Contact: jean paul casalta 0491387587 firstname.lastname@example.org|
|Principal Investigator: jean-paul casalta|
|Study Director:||URIELLE DESALBRES||Assistance Publique Hopitaux De Marseille|
|Principal Investigator:||JEAN PAUL CASALTA||Assistance Publique Hopitaux De Marseille|