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Efficacy and Cost-effectiveness of Hospital Antimicrobial Stewardship Programs (CEFECA)

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ClinicalTrials.gov Identifier: NCT02814877
Recruitment Status : Recruiting
First Posted : June 28, 2016
Last Update Posted : July 5, 2017
Sponsor:
Information provided by (Responsible Party):
Assistance Publique - Hôpitaux de Paris

Brief Summary:
The main objective of the project is to evaluate the efficiency and cost-effectiveness of different strategies aiming at optimizing antibiotic prescribing in hospitals. In the first section of the project, the project team intend to map the different antimicrobial stewardship programs in French hospital, by investigating a sample of 30 healthcare facilities, and determine the strategies to be evaluated by the model. The investigators will also evaluate physicians' adherence to the intervention to promote better use of antibiotics and explore potential barriers and facilitators to the implementation of effective strategies.

Condition or disease Intervention/treatment
Antimicrobial Resistance Other: promotion of appropriate use of antibiotics in hospital

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Ecologic or Community
Time Perspective: Prospective
Official Title: Efficacy and Cost-effectiveness of Hospital Antimicrobial Stewardship Programs
Actual Study Start Date : September 2016
Estimated Primary Completion Date : September 2017
Estimated Study Completion Date : December 2017

Resource links provided by the National Library of Medicine



Intervention Details:
  • Other: promotion of appropriate use of antibiotics in hospital
    promotion of appropriate use of antibiotics in hospital by visiting physicians


Primary Outcome Measures :
  1. Evaluate the efficacy and the cost-effectiveness of strategies to promote appropriate use of antibiotics in hospitals and identify the most efficient ones, on a short-term but also long-term scale. [ Time Frame: 12 months ]
    A comparison of the different strategies based on the incremental cost-effectiveness ratio (ICER), which is defined by the difference in costs between interventions, divided by the difference in their measured impact


Secondary Outcome Measures :
  1. to map the different antimicrobial stewardship setups in french hospital [ Time Frame: 12 months ]
    accrue high-value information in the field of antibiotic stewardship,

  2. to measure prescribers' adherence to the different strategies used to control antibiotic description [ Time Frame: 12 months ]
    namely physicians' adherence to antibiotic counselling and interventions to control its use for the effective implementation of such programs.

  3. to identify potential barriers and facilitators to the implementation of effective stewardship programs [ Time Frame: 12 months ]
    namely physicians' adherence to antibiotic counselling and potential barriers and facilitators for the effective implementation of such programs.



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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
healthcare facilities
Criteria

Inclusion Criteria:

  • French hospitals (acute care) selected

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02814877


Contacts
Contact: Jean Christophe LUCET, PHD 1 40 25 61 94 ext 33 jean-christophe.lucet@aphp.fr
Contact: Anne Perozziello 1 40 25 61 94 ext 33 anne.perozziello@aphp.fr

Locations
France
Perozziello Recruiting
Paris, France
Contact: anne perozziello       anne.perozziello@aphp.fr   
Sponsors and Collaborators
Assistance Publique - Hôpitaux de Paris
Investigators
Principal Investigator: Jean Christophe LUCET APHP

Responsible Party: Assistance Publique - Hôpitaux de Paris
ClinicalTrials.gov Identifier: NCT02814877     History of Changes
Other Study ID Numbers: PHRQ15622
First Posted: June 28, 2016    Key Record Dates
Last Update Posted: July 5, 2017
Last Verified: July 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by Assistance Publique - Hôpitaux de Paris:
Antibiotic stewardship
cost-effectiveness evaluation
Antibiotic use

Additional relevant MeSH terms:
Anti-Bacterial Agents
Antibiotics, Antitubercular
Anti-Infective Agents
Antitubercular Agents