Effects of Total Intravenous Anesthesia With Propofol-remifentanil Versus Inhalational Anesthesia With Sevoflurane on Quality of Recovery in Patients Undergoing Transsphenoidal Surgery for Pituitary Tumor
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02813044|
Recruitment Status : Recruiting
First Posted : June 24, 2016
Last Update Posted : January 10, 2019
|Condition or disease||Intervention/treatment||Phase|
|Pituitary Tumor||Drug: total intravenous anesthesia (TIVA) Drug: inhalation anesthesia group||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||82 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Actual Study Start Date :||June 16, 2016|
|Estimated Primary Completion Date :||November 2019|
|Estimated Study Completion Date :||November 2019|
Experimental: TIVA group
Anesthesia is maintained with propofol during surgery
Drug: total intravenous anesthesia (TIVA)
In the TIVA group,anesthesia is induced and maintained by effect-site target controlled infusion of propofol and remifentanil.
Active Comparator: inhalation anesthesia group
Anesthesia is maintained with sevoflurane during surgery
Drug: inhalation anesthesia group
In the inhalation anesthesia group, anesthesia is induced by pentothal sodium 4-6mg/kg and remifentanil 1 μg/kg, and then maintained with end-tidal sevoflurane concentration of 0.8 to 1 MAC and continuous infusion of remifentanil at 0.1-0.3μg/kg/min.
- QoR-40 score [ Time Frame: 1 day ]We compare the QoR-40 scores of two groups 1 day after the operation.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02813044
|Korea, Republic of|
|Associate Professor Department of Anesthesiology and Pain Medicine,||Recruiting|
|Seoul, Korea, Republic of, 120-752|
|Contact: Seung Ho Cho, Ph.D 82-2-2228-2427 firstname.lastname@example.org|