Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia (MUTA-GR)
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ClinicalTrials.gov Identifier: NCT02810496
Recruitment Status : Unknown
Verified June 2016 by CHU de Reims. Recruitment status was: Recruiting
As the investigators observed a case of glucocorticoid mutation revealed by incidentally discovered bilateral adrenal nodular hyperplasia, it was postulated that this molecular anormality could be more frequent than previously described. To validate this hypothesis, it was decided to study 150 multicenter consecutive patients, presenting with incidentally discovered bilateral adrenal masses without clinical signs of Cushing's disease. In all these patients GR gene will be studied, mutations will be detected and described, functional disturbance will be tested. Usual polymorphisms will be described. Correlation between clinical signs, hormonal and morphological abnormalities and presence or absence of GR mutations will be searched.
Condition or disease
General Glucocorticoid Resistance
Genetic: blood collection for mutation characterization
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