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Individualized Molecular Profiling for Allocation to Clinical Trials (IMPACT) Project (IMPACT)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT02806388
Recruitment Status : Recruiting
First Posted : June 20, 2016
Last Update Posted : September 14, 2018
Information provided by (Responsible Party):
National Cancer Centre, Singapore

Brief Summary:
This study aims to screen tumor molecular profile for better selection of anticancer treatment, in particular, allocation to clinical trials if available.

Condition or disease
Solid Tumor

Detailed Description:
Molecular profiling will be performed on archival tumor tissue or freshly collected tumor tissue from re-biopsy. Blood and/or saliva may be collected to study the genetic makeup and also to compare the tumor molecular profile. Personalized therapy will be given based on molecular profile.

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Study Type : Observational
Estimated Enrollment : 1500 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Individualized Molecular Profiling for Allocation to Clinical Trials (IMPACT) Project
Study Start Date : October 2011
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : December 2019

tumor tissue for molecular profiling

Primary Outcome Measures :
  1. The molecular and clinical epidemiology for cancer patients being considered for novel therapeutics [ Time Frame: 5 years ]

Secondary Outcome Measures :
  1. The proportion of patients who have actionable alterations and enrol into clinical trials [ Time Frame: 5 years ]
  2. The correlation of molecular profiles with clinical outcomes [ Time Frame: 5 years ]

Biospecimen Retention:   Samples With DNA
Remaining tumor and/or blood and/or saliva

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   21 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Any advanced cancer patient who would benefit from molecular profiling and is a potential clinical trial candidate as identified by treating physician.

Inclusion Criteria:

  • Confirmed histological diagnosis of solid tumor
  • Suitable for systematic treatment and clinical trials
  • ECOG (Eastern cooperative oncology group) performance status < 2
  • Able to provide tumor tissue for molecular profiling
  • Able to understand and sign the informed consent form

Exclusion Criteria:

  • None

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02806388

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Contact: Daniel SW Tan +65 6436 8000

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National Cancer Centre singapore Recruiting
Singapore, Singapore
Sponsors and Collaborators
National Cancer Centre, Singapore
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Principal Investigator: Daniel SW Tan National Cancer Centre, Singapore

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: National Cancer Centre, Singapore Identifier: NCT02806388     History of Changes
Other Study ID Numbers: ECRU-IMPACT
First Posted: June 20, 2016    Key Record Dates
Last Update Posted: September 14, 2018
Last Verified: September 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No