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Trial record 41 of 48 for:    Recruiting, Not yet recruiting, Available Studies | "Carotid Stenosis"

Physiopathological and Therapeutic Value of microRNA in the Progression of Carotid Artery Plaques: Carotid Protocol and microRNA (CAMIA2)

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ClinicalTrials.gov Identifier: NCT02804659
Recruitment Status : Recruiting
First Posted : June 17, 2016
Last Update Posted : August 10, 2018
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier Universitaire, Amiens

Brief Summary:
Molecular analysis of the atheroma plaque. Screening for a novel biomarker of carotid status.

Condition or disease Intervention/treatment
Carotid Arteries Other: microRNA

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Study Type : Observational
Estimated Enrollment : 120 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Physiopathological and Therapeutic Value of microRNA in the Progression of Carotid Artery Plaques: Carotid Protocol and microRNA
Study Start Date : July 2013
Estimated Primary Completion Date : March 2019
Estimated Study Completion Date : March 2019

Intervention Details:
  • Other: microRNA
    Extraction of the microRNA using the mirVana miRNA isolation kit and quantification using real-time PCRs


Primary Outcome Measures :
  1. expression level of the seven miRNAs of interest [ Time Frame: Day of surgery ]
    expression level of the seven miRNAs of interest in the serum and in carotid artery plaques : miR-100, miR-125a, miR-127, miR-133a, miR-145, miR-221


Biospecimen Retention:   Samples Without DNA
carotid artery plaques blood


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Adults having to undergo carotid thrombendarteriectomy
Criteria

Inclusion Criteria:

  • Adults having to undergo carotid thromboendarteriectomy
  • social security coverage
  • provision of study information
  • consent to participation.

Exclusion Criteria:

  • Previous carotid artery surgery
  • refusal to participate in the study
  • or inability to give consent.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02804659


Contacts
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Contact: Pierre MAITRIAS, PhD +33 3 22 08 72 67 maitrias.pierre@chu-amiens.fr

Locations
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France
CHU Amiens Recruiting
Amiens, France, 80054
Contact: Pierre MAITRIAS, PhD    +33 3 22 08 72 67    maitrias.pierre@chu-amiens.fr   
Sponsors and Collaborators
Centre Hospitalier Universitaire, Amiens
Investigators
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Principal Investigator: Pierre MAITRIAS, PhD CHU Amiens

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Responsible Party: Centre Hospitalier Universitaire, Amiens
ClinicalTrials.gov Identifier: NCT02804659     History of Changes
Other Study ID Numbers: PI2014_843_0024
First Posted: June 17, 2016    Key Record Dates
Last Update Posted: August 10, 2018
Last Verified: August 2018

Keywords provided by Centre Hospitalier Universitaire, Amiens:
micro-RNA

Additional relevant MeSH terms:
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Carotid Stenosis
Carotid Artery Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases