Stress Sensitivity and Reward Responsivity in Depression (CAN-BIND-04)
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ClinicalTrials.gov Identifier: NCT02798094 |
Recruitment Status :
Completed
First Posted : June 14, 2016
Last Update Posted : August 28, 2019
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Condition or disease |
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Depressed |
Participants will participate in two 3-hour sessions separated by a week at Providence Care, Mental Health Services, and a third, 1.5-hour session at the Queen's MRI Facility. At the first session participants will complete a packet of questionnaires about their mood and take part in an interview about their mood, medications, drug use, and any other symptoms, as well as an interview about their relationships with their parents and any experiences of abuse. At the second session participants will participate in a stress test, which involves giving a speech to a panel. The investigators will also collect saliva samples to look at stress hormones. Participants will also complete a task on the computer that involves looking at cartoon faces and making decisions about them. At the third session, the investigators take images of of participant's brain using a magnetic resonance scanner.
Participants are invited to participate in a 6-month follow-up for this study, which would involve the same procedure as outline above.
Study Type : | Observational |
Actual Enrollment : | 219 participants |
Observational Model: | Case-Control |
Time Perspective: | Prospective |
Official Title: | Stress Sensitivity and Reward Responsivity: An Integration of Two Endophenotypes in Major Depression |
Actual Study Start Date : | July 2015 |
Actual Primary Completion Date : | December 31, 2018 |
Actual Study Completion Date : | December 31, 2018 |

Group/Cohort |
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Depressed Participants
No intervention
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Healthy Control Participants
No intervention
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- Stress Sensitivity: Salivary Hormone and Stress Challenge Test (TSST) [ Time Frame: 2 hours after beginning of Time B Appointment ]Participants are required to give a speech and an arithmetic test in front of a panel. Saliva samples are collected at 8 points throughout the test.
- Mood and Anxiety Symptom Questionnaire (MASQ) [ Time Frame: Administered at first baseline appointment and covers past 2 weeks ]Self-report scale of general distress (GD), anhedonic depression (AD), and anxious arousal (AA) symptoms
- Reward Responsivity: Probabilistic Reward Task [ Time Frame: Administered at second baseline appointment ]Computerized task that requires participants to choose between two stimuli and develop a response bias to the more frequently rewarded stimulus.
- Snaith Hamilton Pleasure Scale (SHAPS and SHAPS-C) [ Time Frame: Administered at first baseline appointment and covers past 2 weeks prior to interview ]Self-report of anhedonia symptoms
Biospecimen Retention: Samples Without DNA

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
For Depressed Participants:
Inclusion Criteria:
- Outpatients aged 18-65
- Currently suffering from unipolar depression
- Fluency in English, sufficient to complete the interviews and self-report questionnaires
Exclusion Criteria:
- Clinical diagnosis of bipolar disorder, psychotic disorders, current alcohol/substance dependence, or significant medical comorbidity
- Treatment-resistant (defined as failing more than 3 trials of anti-depressant medication)
- History of neurological insult (e.g., concussion), neurological disease, seizure disorder
- Smokers
- Pregnant women
- Endocrine disorders
- High suicidal risk, defined by clinician judgement
For Healthy Control Participants:
Inclusion Criteria:
- Adults aged 18-65
- No history of Axis I disorders according to DSM-IV-TR criteria, as determined by the SCID
- No first-degree relatives diagnosed with bipolar disorder
- Fluency in English, sufficient to complete the interviews and self-report questionnaires
Exclusion Criteria:
- History of neurological insult (e.g., concussion), neurological disease, seizure disorder
- Smokers
- Pregnant women
- Endocrine disorders

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02798094
Canada, Ontario | |
Queen's University | |
Kingston, Ontario, Canada, K7L 3N6 |
Principal Investigator: | Kate Harkness, PhD | Queens University |
Responsible Party: | Dr. Kate Harkness, Dr., Queen's University |
ClinicalTrials.gov Identifier: | NCT02798094 |
Other Study ID Numbers: |
PSYC-154-14 |
First Posted: | June 14, 2016 Key Record Dates |
Last Update Posted: | August 28, 2019 |
Last Verified: | August 2019 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | Undecided |
Depression Behavioral Symptoms |