Stress Sensitivity and Reward Responsivity in Depression (CAN-BIND-04)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02798094|
Recruitment Status : Recruiting
First Posted : June 14, 2016
Last Update Posted : April 10, 2018
|Condition or disease|
Participants will participate in two 3-hour sessions separated by a week at Providence Care, Mental Health Services, and a third, 1.5-hour session at the Queen's MRI Facility. At the first session participants will complete a packet of questionnaires about their mood and take part in an interview about their mood, medications, drug use, and any other symptoms, as well as an interview about their relationships with their parents and any experiences of abuse. At the second session participants will participate in a stress test, which involves giving a speech to a panel. The investigators will also collect saliva samples to look at stress hormones. Participants will also complete a task on the computer that involves looking at cartoon faces and making decisions about them. At the third session, the investigators take images of of participant's brain using a magnetic resonance scanner.
Participants are invited to participate in a 6-month follow-up for this study, which would involve the same procedure as outline above.
|Study Type :||Observational|
|Estimated Enrollment :||200 participants|
|Official Title:||Stress Sensitivity and Reward Responsivity: An Integration of Two Endophenotypes in Major Depression|
|Actual Study Start Date :||July 2015|
|Estimated Primary Completion Date :||April 1, 2019|
|Estimated Study Completion Date :||May 1, 2019|
Healthy Control Participants
- Stress Sensitivity: Salivary Hormone and Stress Challenge Test (TSST) [ Time Frame: 2 hours after beginning of Time B Appointment ]Participants are required to give a speech and an arithmetic test in front of a panel. Saliva samples are collected at 8 points throughout the test.
- Mood and Anxiety Symptom Questionnaire (MASQ) [ Time Frame: Administered at first baseline appointment and covers past 2 weeks ]Self-report scale of general distress (GD), anhedonic depression (AD), and anxious arousal (AA) symptoms
- Reward Responsivity: Probabilistic Reward Task [ Time Frame: Administered at second baseline appointment ]Computerized task that requires participants to choose between two stimuli and develop a response bias to the more frequently rewarded stimulus.
- Snaith Hamilton Pleasure Scale (SHAPS and SHAPS-C) [ Time Frame: Administered at first baseline appointment and covers past 2 weeks prior to interview ]Self-report of anhedonia symptoms
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02798094
|Contact: Raymond MacNeil, BAHemail@example.com|
|Kingston, Ontario, Canada, K7L 3N6|
|Contact: Raymond MacNeil, BAH 613-533-6003 firstname.lastname@example.org|
|Principal Investigator: Kate Harkness, PhD|
|Sub-Investigator: Roumen Milev, MD|
|Principal Investigator:||Kate Harkness, PhD||Queens University|