tDCS Effects on GABA Concentration and Brain Functional Connectivity in Older Adults Of Working Age (TRAINSTIM1)
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|ClinicalTrials.gov Identifier: NCT02794272|
Recruitment Status : Completed
First Posted : June 9, 2016
Last Update Posted : January 6, 2017
|Condition or disease||Intervention/treatment||Phase|
|Healthy Older Adults||Device: tDCS Device: sham-tDCS||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||24 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||Effects of Transcranial Direct Current Stimulation (tDCS) on GABA Concentration and Brain Functional Connectivity in Older Adults.|
|Study Start Date :||April 2016|
|Actual Primary Completion Date :||July 2016|
|Actual Study Completion Date :||August 2016|
Experimental: Anodal tDCS
Anodal stimulation during resting state fMRI
Experimental: Cathodal tDCS
Cathodal stimulation during resting state fMRI
Sham Comparator: sham tDCS
Sham stimulation during resting state fMRI
- GABA concentration assessed by magnetic resonance spectroscopy (MRS) before and after anodal tDCS adjusted for baseline levels [ Time Frame: assessed immediately before and after a 15-min stimulation time ]Investigation whether anodal tDCS leads to a significant reduction of M1-GABA concentration in older adults compared to sham stimulation.
- GABA concentration assessed by MRS before and after cathodal tDCS adjusted for baseline levels [ Time Frame: assessed immediately before and after a 15-min stimulation time ]To assess stimulation effects on GABA concentration by magnetic resonance spectroscopy are measured before and after cathodal tDCS.
- Resting-state functional connectivity changes [ Time Frame: assessed during a 15-min stimulation time ]Functional connectivity as measured by resting-state fMRI during tDCS compared to sham
- Genotyping of learning related polymorphisms [ Time Frame: assessed during baseline screening ]To assess predictors of positive reaction to brain stimulation, genotyping of several learning related polymorphisms will be performed.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02794272
|Charité Universitätsmedizin Berlin|
|Berlin, Germany, 10117|
|Principal Investigator:||Agnes Flöel, Prof. Dr.||Charite University, Berlin, Germany|