Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis
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The purpose of this study is to evaluate the association of Rheumatoid Arthritis (RA)-related antibodies and periodontal inflammation in subjects at-risk for Rheumatoid Arthritis. Subjects will undergo periodontal and joint examinations, as well as collection of body fluids to measure Rheumatoid Arthritis-related antibodies.
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Ages Eligible for Study:
18 Years to 99 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
The study population will include: subjects at-risk for RA, subjects with early RA, and healthy controls >40 years old.
Rheumatoid Arthritis-antibody positivity (anti-CCP) in the absence of arthritis or
Early RA <36 months since diagnosis
Antibiotic use prior to dental procedures or cleanings