Ovarian Function and Reserve Parameters After Discontinuation of Long-term Use of Oral Contraception
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|ClinicalTrials.gov Identifier: NCT02785809|
Recruitment Status : Recruiting
First Posted : May 30, 2016
Last Update Posted : May 30, 2016
|Condition or disease||Intervention/treatment|
|Oral Contraceptives Long-term Use AMH Ovarian Reserve Parameters||Other: Pausing oral contraceptive|
Hormonal contraception is widely used among women worldwide; 50-89% of all women in the Western countries use oral contraception at some point in their lives. Oral contraceptives (OC) suppress the hypothalamic-pituitary-ovarian axis through a negative feedback of ethinyl estradiol and progestins and thereby potentially influence the markers of ovarian reserve due to a suppressed release of gonadotropins, which will impair the growth of antral follicles.
Methods and Materials:
Participants for this studies will be included through the Fertility Assessment and Counseling Clinic, Rigshospitalet, Herlev- and Hvidovre Hospital.
Inclusion criteria: Use of oral contraception (for study 3 at least during the last three years).
Exclusion criteria: Known infertility, known thyroid disease.
Study 3: Investigate the ovarian reserve markers after discontinuation of OC over a period of three months in women with a history of long-term OC use. The women will be followed with serial ultrasounds and blood samples and will complete a menstrual calendar.
|Study Type :||Observational|
|Estimated Enrollment :||50 participants|
|Official Title:||Recovery of Ovarian Function and Reserve Parameters After Discontinuation of Long-term Use of Oral Contraception: Is the Recovery Period Related to AMH?|
|Study Start Date :||April 2016|
|Estimated Primary Completion Date :||May 2019|
|Estimated Study Completion Date :||March 2020|
- Time for recovered menstrual cycle after discontinuation of oral contraception [ Time Frame: 6 months after discontinuation ]
- Ovarian reserve parameters before and after discontinuation of combined oral contraception [ Time Frame: 3 months after discontinuation ]
- Correlation between suppression of the pituitary gonodal axis during use of oral contraceptives and time for recovered menstrual cycle [ Time Frame: 3 months ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02785809
|Contact: Selma K Landersoe, MD||+45 35 45 49 firstname.lastname@example.org|
|Contact: Anders N Andersen, Professor, MD||+45 35 45 13 email@example.com|
|Copenhagen University Hospital, Rigshospitalet, The Fertility Clinic||Recruiting|
|Copenhagen, Denmark, 2100|
|Contact: Anders N Andersen, Professor +4535451315 firstname.lastname@example.org|
|Contact: Selma K Landersø, MD +45 3545 4951 email@example.com|
|Principal Investigator: Selma K Landersoe, MD|
|Sub-Investigator: Anders N Andersen, Professor|
|Principal Investigator:||Selma K Landersoe, MD||Rigshospitalet, The Fertility Clinic|