Investigating Central Mechanisms of Overactive Bladder in Adults With Parkinson's Disease
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|ClinicalTrials.gov Identifier: NCT02783014|
Recruitment Status : Unknown
Verified June 2018 by Pinky Agarwal, MD, EvergreenHealth.
Recruitment status was: Active, not recruiting
First Posted : May 26, 2016
Last Update Posted : June 13, 2018
This study investigates the central mechanisms of Overactive Bladder (OAB) in Patients with Parkinson's Disease (PD).
The plan is to enroll 10 adults with Parkinson's disease and Overactive bladder (PD + OAB) and 10 adults with Parkinson's disease only (PD). Both groups will undergo fMRI (functional MRI).
|Condition or disease|
Overactive bladder (OAB) is a physical problem that causes strong urges to urinate, frequent urination, and sometimes urinary incontinence (accidental loss of urine control) commonly in patients with Parkinson' disease (PD) severely impacting their quality of life.
Unfortunately OAB in adults with PD is difficult to treat. This is largely because the mechanisms underlying OAB in adults with PD are not known. Recent functional MRI (fMRI) studies suggest that certain areas of the brain have an important role in OAB. Blood oxygenation level dependent (BOLD) fMRI is an imaging technique in which neural activity of a region of the brain can be measured by fluctuation in the BOLD signal. It is hoped that the findings of this study will allow the development of new treatments for adults with Parkinson's disease and overactive bladder.
|Study Type :||Observational|
|Estimated Enrollment :||20 participants|
|Official Title:||Case-control Study Investigating Central Mechanisms of Overactive Bladder in Adults With Parkinson's Disease and Overactive Bladder and Adults With Parkinson's Disease Only|
|Study Start Date :||June 2016|
|Actual Primary Completion Date :||May 2017|
|Estimated Study Completion Date :||May 2019|
- Comparison of perfusion activity in the Limbic System [ Time Frame: 1 hour functional Magnetic Resonance Imaging (fMRI) ]Comparison of the perfusion activity in the limbic system between subjects with Parkinson's Disease and Overactive Bladder and Parkinson's disease only using Blood Oxygenation Level Dependent (BOLD) functional Magnetic Resonance Imaging (fMRI) contrast maps. It will be performed at the second visit.
- Determination on the relationship of perfusion activity in the limbic system and anxiety. [ Time Frame: 1 hour functional Magnetic Resonance Imaging (fMRI) - 10 Minutes questionnaire. ]Determination of the relationship of perfusion activity in the limbic system and anxiety scores (using Zung's Self-rating Anxiety Scale (SAS)) in subjects with Parkinson's Disease and Overactive Bladder.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02783014
|United States, Washington|
|Kirkland, Washington, United States, 98034|
|Principal Investigator:||Pinky Agarwal, MD||EvergreenHealth|